-
公开(公告)号:US20110173928A1
公开(公告)日:2011-07-21
申请号:US13074183
申请日:2011-03-29
申请人: Andrea FETZ , Georg Ludwig Kis , Michel Pepiot
发明人: Andrea FETZ , Georg Ludwig Kis , Michel Pepiot
摘要: The present invention describes in particular a method for stabilizing a pharmaceutical composition by contacting said composition with a polymeric material comprising in particular an ethylene oxide sterilization step.
摘要翻译: 本发明特别地描述了通过使所述组合物与包含特别是环氧乙烷灭菌步骤的聚合材料接触来稳定药物组合物的方法。
-
公开(公告)号:US20080300277A1
公开(公告)日:2008-12-04
申请号:US12016428
申请日:2008-01-18
申请人: Andrea Fetz , Georg Ludwig Kis , Michel Pepiot
发明人: Andrea Fetz , Georg Ludwig Kis , Michel Pepiot
IPC分类号: A61K31/4535 , A61P27/02
摘要: The present invention describes in particular a method for stabilizing a pharmaceutical composition by contacting said composition with a polymeric material comprising in particular an ethylene oxide sterilization step.
摘要翻译: 本发明特别地描述了通过使所述组合物与包含特别是环氧乙烷灭菌步骤的聚合材料接触来稳定药物组合物的方法。
-
公开(公告)号:US20090110734A1
公开(公告)日:2009-04-30
申请号:US12238473
申请日:2008-09-26
IPC分类号: A61K9/10 , C07H15/04 , A61K31/7028 , A61K38/02
CPC分类号: A61K31/724 , A61K31/196 , A61K31/4535 , C08B37/0012
摘要: Use of a compound of formula (I): wherein the symbol represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; xm− is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.
摘要翻译: 式(I)化合物的用途:其中符号表示通过除去其羟基而衍生自环糊精化合物的n价残基; n是大于0的数,表示每分子所述化合物的式的取代基的平均数; h为0或1; R1是选自亚烷基,羟基亚烷基,卤代亚烷基,单环亚芳基,亚环烷基和亚苯基的二价基团; R2,R3和R4各自独立地为选自烷基,环烷基,芳基,芳烷基和环戊基的基团; xm-是m-带负电荷的阴离子; m是等于或大于1的整数; 在制备抗感染药物中,k为n / m,作为防腐剂和渗透促进剂。
-
公开(公告)号:US20080287553A1
公开(公告)日:2008-11-20
申请号:US12173439
申请日:2008-07-15
IPC分类号: A61K47/40
CPC分类号: A61K9/0048 , A61K47/40
摘要: The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译: 本发明涉及一种包含环戊二烯环糊精,药物和载体的药物组合物,以使用环戊二烯环糊精作为药物转运增强剂(例如渗透促进剂),以及在制备药物组合物中使用环糊精 协同辅助系统。
-
公开(公告)号:US20100056476A1
公开(公告)日:2010-03-04
申请号:US12617074
申请日:2009-11-12
IPC分类号: A61K31/715 , C07H1/00
CPC分类号: A61K9/0048 , A61K47/40
摘要: The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译: 本发明涉及一种包含环戊二烯环糊精,药物和载体的药物组合物,以使用环戊二烯环糊精作为药物转运增强剂(例如渗透促进剂),以及在制备药物组合物中使用环糊精 协同辅助系统。
-
公开(公告)号:US20120004158A1
公开(公告)日:2012-01-05
申请号:US13234912
申请日:2011-09-16
IPC分类号: A61K38/00 , A61P31/04 , A61K31/711 , A61P31/10 , A61K31/7105 , A61K31/715 , A61P31/00
CPC分类号: A61K31/724 , A61K31/196 , A61K31/4535 , C08B37/0012
摘要: Use of a compound of formula (I): wherein the symbol cyclodextrin ]n represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; Xm− is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.
摘要翻译: 式(I)化合物的用途:其中符号环糊精] n表示通过除去其羟基而衍生自环糊精化合物的n价残基; n是大于0的数,表示每分子所述化合物的式的取代基的平均数; h为0或1; R1是选自亚烷基,羟基亚烷基,卤代亚烷基,单环亚芳基,亚环烷基和亚苯基的二价基团; R2,R3和R4各自独立地为选自烷基,环烷基,芳基,芳烷基和环戊基的基团; Xm-是一个m-带负电荷的阴离子; m是等于或大于1的整数; 在制备抗感染药物中,k为n / m,作为防腐剂和渗透促进剂。
-
公开(公告)号:US20080233182A1
公开(公告)日:2008-09-25
申请号:US12052016
申请日:2008-03-20
CPC分类号: A61K33/34 , A23L33/105 , A23L33/12 , A23L33/15 , A23L33/16 , A23P20/10 , A61K9/4825 , A61K31/30 , A61K31/355 , A61K31/375 , A61K47/6951 , B82Y5/00 , A61K2300/00
摘要: The present invention relates to a method of protecting copper-sensitive compounds and/or compositions from decomposition.
摘要翻译: 本发明涉及一种保护铜敏化合物和/或组合物免于分解的方法。
-
-
-
-
-
-