公开(公告)号：US20100241077A1

公开(公告)日：2010-09-23

申请号：US12725819

申请日：2010-03-17

申请人： Andreas Geipel ,  Florian Kuhni ,  Christoph Huwiler ,  Ulrich Haueter

发明人： Andreas Geipel ,  Florian Kuhni ,  Christoph Huwiler ,  Ulrich Haueter

IPC分类号： A61M5/162 ,  A61M5/142 ,  G01L9/12

CPC分类号： A61M5/158 ,  A61M5/16854 ,  A61M2205/0244 ,  A61M2205/33 ,  A61M2205/3331 ,  G01L9/0005 ,  G01L9/0041

摘要： Cannula assemblies with pressure sensors made of stacked coplanar layers and ambulatory infusion systems comprising the same are disclosed. The cannula assemblies include a hub and an infusion cannula. The hub includes a pressure sensor and a fluid channel fluidly coupled to the infusion cannula. The pressure sensor is formed from a stack of coplanar layers including a top layer, a base layer an electrode layer and a counter electrode layer. The fluid channel is positioned between the top layer and the base layer. The electrode layer is positioned between the top layer and the base layer and coupled to the fluid channel. The counter-electrode layer is positioned between the top layer and the electrode layer. A spacer layer having a through cut-out defining an electrode cavity is disposed between the top layer and the base layer such that the electrode layer extends across the electrode cavity.

摘要翻译： 公开了具有由堆叠的共面层制成的压力传感器和包括其的动态输注系统的插管组件。 套管组件包括轮毂和输液套管。 毂包括压力传感器和流体地联接到输注套管的流体通道。 压力传感器由包括顶层，基底层，电极层和对电极层的共面层组成。 流体通道位于顶层和基层之间。 电极层位于顶层和底层之间，并连接到流体通道。 对电极层位于顶层和电极层之间。 具有限定电极腔的通孔的间隔层设置在顶层和基层之间，使得电极层延伸穿过电极腔。

公开(公告)号：US08313468B2

公开(公告)日：2012-11-20

申请号：US12725819

申请日：2010-03-17

申请人： Andreas Geipel ,  Florian Kuhni ,  Christoph Huwiler ,  Ulrich Haueter

发明人： Andreas Geipel ,  Florian Kuhni ,  Christoph Huwiler ,  Ulrich Haueter

IPC分类号： A61M5/162 ,  G01L9/12

CPC分类号： A61M5/158 ,  A61M5/16854 ,  A61M2205/0244 ,  A61M2205/33 ,  A61M2205/3331 ,  G01L9/0005 ,  G01L9/0041

摘要： Cannula assemblies with pressure sensors made of stacked coplanar layers and ambulatory infusion systems comprising the same are disclosed. The cannula assemblies include a hub and an infusion cannula. The hub includes a pressure sensor and a fluid channel fluidly coupled to the infusion cannula. The pressure sensor is formed from a stack of coplanar layers including a top layer, a base layer an electrode layer and a counter electrode layer. The fluid channel is positioned between the top layer and the base layer. The electrode layer is positioned between the top layer and the base layer and coupled to the fluid channel. The counter-electrode layer is positioned between the top layer and the electrode layer. A spacer layer having a through cut-out defining an electrode cavity is disposed between the top layer and the base layer such that the electrode layer extends across the electrode cavity.

摘要翻译： 公开了具有由堆叠的共面层制成的压力传感器和包括其的动态输注系统的插管组件。 套管组件包括轮毂和输液套管。 毂包括压力传感器和流体地联接到输注套管的流体通道。 压力传感器由包括顶层，基底层，电极层和对电极层的共面层组成。 流体通道位于顶层和基层之间。 电极层位于顶层和底层之间，并连接到流体通道。 对电极层位于顶层和电极层之间。 具有限定电极腔的通孔的间隔层设置在顶层和基层之间，使得电极层延伸穿过电极腔。

公开(公告)号：US08720496B2

公开(公告)日：2014-05-13

申请号：US12939272

申请日：2010-11-04

申请人： Christoph Huwiler ,  Florian Kuehni ,  Gerald Studer ,  Martin Wyss ,  Ulrich Haueter ,  David Teutsch

发明人： Christoph Huwiler ,  Florian Kuehni ,  Gerald Studer ,  Martin Wyss ,  Ulrich Haueter ,  David Teutsch

IPC分类号： B65B3/14

CPC分类号： B65B3/14 ,  A61J1/10 ,  A61J1/2075 ,  A61J1/2089 ,  A61M5/14244 ,  A61M5/38 ,  A61M2039/1077 ,  A61M2039/224 ,  A61M2209/045

摘要： A device, kit, and method for transferring a liquid medicament from a supply container to a flexible reservoir container are disclosed. The device may comprise a compartment unit and an adapter unit. The compartment unit may have a sealingly closable chamber, arranged for housing the flexible reservoir container and for being fluidly connected with a pump mechanism. The adapter unit may have at least one transfer passage for transferring liquid from a supply container connected to the adapter unit to the flexible reservoir container, and a separator arranged in the transfer passage for separating gas bubbles from a liquid streaming through the transfer passage. The separator may be fluidly connected to the chamber.

摘要翻译： 公开了一种用于将液体药物从供应容器转移到柔性贮存器容器的装置，试剂盒和方法。 该装置可以包括隔室单元和适配器单元。 隔室单元可以具有可密封关闭的室，其布置成容纳柔性储存容器并且与泵机构流体连接。 适配器单元可以具有至少一个传送通道，用于将液体从连接到适配器单元的供应容器传送到柔性容器容器，以及布置在传送通道中的分离器，用于将气泡与通过传送通道流出的液体分离。 分离器可以流体地连接到室。

公开(公告)号：US20110108158A1

公开(公告)日：2011-05-12

申请号：US12939272

申请日：2010-11-04

申请人： Christoph Huwiler ,  Florian Kuehni ,  Gerald Studer ,  Martin Wyss ,  Ulrich Haueter ,  David Teutsch

发明人： Christoph Huwiler ,  Florian Kuehni ,  Gerald Studer ,  Martin Wyss ,  Ulrich Haueter ,  David Teutsch

IPC分类号： B65B31/02

CPC分类号： B65B3/14 ,  A61J1/10 ,  A61J1/2075 ,  A61J1/2089 ,  A61M5/14244 ,  A61M5/38 ,  A61M2039/1077 ,  A61M2039/224 ,  A61M2209/045

摘要： A device, kit, and method for transferring a liquid medicament from a supply container to a flexible reservoir container are disclosed. The device may comprise a compartment unit and an adapter unit. The compartment unit may have a sealingly closable chamber, arranged for housing the flexible reservoir container and for being fluidly connected with a pump mechanism. The adapter unit may have at least one transfer passage for transferring liquid from a supply container connected to the adapter unit to the flexible reservoir container, and a separator arranged in the transfer passage for separating gas bubbles from a liquid streaming through the transfer passage. The separator may be fluidly connected to the chamber.

摘要翻译： 公开了一种用于将液体药物从供应容器转移到柔性贮存器容器的装置，试剂盒和方法。 该装置可以包括隔室单元和适配器单元。 隔室单元可以具有可密封关闭的室，其布置成容纳柔性储存容器并且与泵机构流体连接。 适配器单元可以具有至少一个传送通道，用于将液体从连接到适配器单元的供应容器传送到柔性容器容器，以及布置在传送通道中的分离器，用于将气泡与通过传送通道流出的液体分离。 分离器可以流体地连接到室。

公开(公告)号：US20140039392A1

公开(公告)日：2014-02-06

申请号：US14049480

申请日：2013-10-09

申请人： Andreas Geipel ,  Joerg Dogwiler ,  Ulrich Haueter ,  Simon Scheurer ,  Rudolf Zihlmann ,  David Teutsch ,  Florian Kuehni ,  Reto Schaltegger

发明人： Andreas Geipel ,  Joerg Dogwiler ,  Ulrich Haueter ,  Simon Scheurer ,  Rudolf Zihlmann ,  David Teutsch ,  Florian Kuehni ,  Reto Schaltegger

IPC分类号： A61M5/36 ,  A61M5/142

摘要： An infusion pump device and method for filling a fluidic system of the infusion pump with liquid medicament prior to infusion operation is presented. A control unit causes the infusion pump to: (a) bring a pump to an initial state; (b) switch a valve to a first state connecting a secondary reservoir to a first conduit and a primary reservoir; (c) retrieve medicament from the primary reservoir; (d) switch the valve to a second state connecting the secondary reservoir to a second downstream conduit; (e) expel the secondary reservoir contents into the second downstream conduit; (f) switch the valve to the first state; (g) retrieve the primary reservoir medicament; (h) switch the valve to the second state; and (i) expel the secondary reservoir contents into the second downstream conduit by shifting a piston to the initial position.

摘要翻译： 提出一种输液泵装置和方法，用于在输注操作之前用液体药物填充输液泵的流体系统。 控制单元使输液泵：（a）使泵进入初始状态; （b）将阀切换到将次级储存器连接到第一管道和主储存器的第一状态; （c）从初级贮存器回收药物; （d）将所述阀切换到将所述辅助容器连接到第二下游导管的第二状态; （e）将第二储存器内容物排出到第二下游导管中; （f）将阀门切换到第一状态; （g）检索主要储存药剂; （h）将阀门切换到第二状态; 和（i）通过将活塞移动到初始位置将次级容器内容物排出到第二下游管道中。

公开(公告)号：US20140007694A1

公开(公告)日：2014-01-09

申请号：US14026808

申请日：2013-09-13

申请人： Andreas Geipel ,  Pascal Grossenbacher ,  Philipp Michel ,  Ulrich Haueter

发明人： Andreas Geipel ,  Pascal Grossenbacher ,  Philipp Michel ,  Ulrich Haueter

IPC分类号： A61M5/142 ,  G01L11/02

CPC分类号： A61M5/16859 ,  A61M5/142 ,  A61M5/16854 ,  A61M2005/16868 ,  A61M2005/16872 ,  A61M2205/3306 ,  A61M2205/702 ,  G01L9/0077 ,  G01L11/02

摘要： A sensor device for use in a medical fluid delivery system, or an infusion pump device, comprises a fluidic chamber with a deformable cover closing at least an area of the chamber and an optical detection system comprising at least one light emitter for emitting one or more incident light beams and a sensor unit for monitoring one or more reflected light beams is presented. In a pressurized state of the fluidic chamber, the deformable cover is deformed such that it forms an inflexion point area within the deformed cover. The one or more incident light beams emitted by the light emitter are directed on the cover such that the one or more incident light beams are reflected essentially in the inflexion point area.

摘要翻译： 用于医疗流体输送系统或输液泵装置的传感器装置包括具有关闭腔室的至少一个区域的可变形盖的流体室和包括至少一个发光器的光学检测系统，用于发射一个或多个 提出入射光束和用于监测一个或多个反射光束的传感器单元。 在流体室的加压状态下，可变形盖变形，使得其在变形的盖内形成拐点。 由光发射器发射的一个或多个入射光束被引导到盖上，使得一个或多个入射光束基本上被反射点区域反射。

公开(公告)号：US20140046288A1

公开(公告)日：2014-02-13

申请号：US14049396

申请日：2013-10-09

申请人： Andreas Geipel ,  Joerg Dogwiler ,  Ulrich Haueter ,  Simon Scheurer ,  Rudolf Zihlmann ,  David Teutsch ,  Florian Kuehni ,  Reto Schaltegger

发明人： Andreas Geipel ,  Joerg Dogwiler ,  Ulrich Haueter ,  Simon Scheurer ,  Rudolf Zihlmann ,  David Teutsch ,  Florian Kuehni ,  Reto Schaltegger

IPC分类号： A61M5/168 ,  A61M5/142

CPC分类号： A61M5/16809 ,  A61M5/142 ,  A61M5/14216 ,  A61M5/31511 ,  A61M5/365 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M2005/14264 ,  A61M2005/16868 ,  A61M2205/3306 ,  A61M2205/3355 ,  A61M2205/3365 ,  A61M2205/3396

摘要： An infusion pump device comprising a primary liquid medicament reservoir, a pump with a secondary reservoir to retrieve medicament from the primary reservoir and to subsequently dose the medicament from the secondary reservoir in adjustable volumes (Vdose,i) to a downstream conduit and a control unit to control the operation of the infusion pump device is presented. For metering the volumes (Vdose,i), the control unit causes the infusion pump device to: (a) determine a maximum refill level (VC,max) for the secondary reservoir, based on external parameters, wherein the maximum refill level does not exceed the maximum capacity of the secondary reservoir; (b) fill the secondary reservoir with medicament from the primary reservoir to the maximum refill level (VC,max); (c) meter and convey the medicament volumes to the downstream conduit; (d) if the secondary reservoir becomes empty, refill the secondary reservoir as in step (b) and continue with step (c).

摘要翻译： 一种输液泵装置，包括初级液体药物储存器，具有辅助贮存器的泵，用于从主储存器检索药物，并且随后以可调节的体积（Vdose，i）向下游管道和控制单元 以控制输液泵装置的操作。 为了计量体积（Vdose，i），控制单元使输液泵装置：（a）基于外部参数确定次级储存器的最大补充水平（VC，最大值），其中最大补充水平不 超过次级水库的最大容量; （b）将副储存器从主贮存器填充至最大补充水平（VC，max）; （c）计量并将药物体积输送到下游导管; （d）如果二次储存器变空，则如步骤（b）中那样重新填充次级储存器，并继续步骤（c）。

公开(公告)号：US20140039396A1

公开(公告)日：2014-02-06

申请号：US14049528

申请日：2013-10-09

申请人： Andreas Geipel ,  Joerg Dogwiler ,  Ulrich Haueter ,  Simon Scheurer ,  Rudolf Zihlmann ,  David Teutsch ,  Florian Kuehni ,  Reto Schaltegger

发明人： Andreas Geipel ,  Joerg Dogwiler ,  Ulrich Haueter ,  Simon Scheurer ,  Rudolf Zihlmann ,  David Teutsch ,  Florian Kuehni ,  Reto Schaltegger

IPC分类号： A61M5/172 ,  A61M5/142

CPC分类号： A61M5/172 ,  A61M5/14216 ,  A61M5/14244 ,  A61M5/16809 ,  A61M5/31511 ,  A61M5/365 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M2005/14264 ,  A61M2005/16868 ,  A61M2205/3306 ,  A61M2205/3355 ,  A61M2205/3365 ,  A61M2205/3396

摘要： A dosing unit for an ambulatory infusion pump device is presented. The dosing unit comprises a cylinder pump with a cylinder and a piston arranged in the cylinder. The piston has a shaft with a first threaded segment interacting with a threaded portion of the cylinder and can be displaced along a longitudinal axis of the cylinder by rotating the piston in regard to the cylinder around the axis. Furthermore, the piston allows for the relative or absolute determination of the longitudinal and/or rotational displacement of the piston in regard to the cylinder. In one embodiment, the piston shaft comprises a second segment provided with optically detectable markings that allow the monitoring of the longitudinal and/or rotational displacement of the piston in regard to the cylinder.

摘要翻译： 提出了一种用于移动式输液泵装置的给药单元。 计量单元包括具有气缸的气缸泵和布置在气缸中的活塞。 活塞具有轴，其具有与气缸的螺纹部分相互作用的第一螺纹部分，并且可以相对于圆柱体围绕轴线旋转活塞，沿着圆柱体的纵向轴线移位。 此外，活塞允许相对或绝对地确定活塞相对于气缸的纵向和/或旋转位移。 在一个实施例中，活塞轴包括设置有光学可检测标记的第二段，其允许监测活塞相对于气缸的纵向和/或旋转位移。

公开(公告)号：US08469930B2

公开(公告)日：2013-06-25

申请号：US13162028

申请日：2011-06-16

申请人： Ulrich Haueter ,  Martin Wyss ,  Florian Kuehni

发明人： Ulrich Haueter ,  Martin Wyss ,  Florian Kuehni

IPC分类号： A61M5/00

CPC分类号： A61M5/14216 ,  A61M5/16804 ,  A61M5/16809

摘要： A dosing unit for an ambulatory infusion device and a method of operation are disclosed. The dosing unit includes a stationary member, a movable member, and a plunger. The movable member and the stationary member, together, make a charging valve and a discharging valve. The plunger is located, at least in part, in a metering cavity of the movable member and the movable member is adapted to selectively couple and decouple a driving unit, such that, by operating the driving unit with the movable member being coupled with the driving unit, the movable member moves with the plunger to maintain a position of the plunger relative to the movable member along a displacement axis, and by operating the driving unit with the movable member being decoupled from the driving unit, the plunger is displaced while the position of the movable member is maintained.

公开(公告)号：US20120310163A1

公开(公告)日：2012-12-06

申请号：US13588042

申请日：2012-08-17

申请人： Ulrich Haueter ,  Florian Kuehni

发明人： Ulrich Haueter ,  Florian Kuehni

IPC分类号： A61M5/168 ,  A61M5/142

CPC分类号： A61M5/168 ,  A61M5/14 ,  A61M5/14216 ,  A61M5/152 ,  A61M5/16809 ,  A61M5/1684 ,  A61M5/16854 ,  A61M5/16859 ,  A61M5/16881 ,  A61M5/31525 ,  A61M39/24 ,  A61M2005/16863 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2205/3379 ,  A61M2205/7536 ,  F04B53/162 ,  G01F11/04

摘要： A dosing device for an infusion system comprises a dosing unit having a variable volume and at least one opening in fluid connection with the variable volume, through which opening the variable volume can be filled with a substance or the substance can be dispensed from the variable volume. The dosing device is operable in a first state for filling the substance from a supply conduit, in a second state for preventing filling and dispensing, or in a third state for dispensing through a dispensing conduit. No direct fluid connection exists between the supply conduit and the dispensing conduit at any time. Methods for dosing a substance with the dosing device.

摘要翻译： 用于输注系统的计量装置包括具有可变体积的计量单元和与可变体积流体连接的至少一个开口，通过该开口，可变体积可以用物质填充，或者该物质可以从可变容积中分配 。 计量装置可处于第一状态，用于在供应管道中填充物质，处于用于防止填充和分配的第二状态，或处于第三状态以通过分配导管分配。 在任何时间，在供应管道和分配管道之间不存在直接的流体连接。 用定量给料装置计量物质的方法。