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公开(公告)号：US09345813B2
公开(公告)日：2016-05-24
申请号：US13491081
申请日：2012-06-07
申请人： Andreas Hogg , Yanik Tardy , Thierry Aellen , Herbert Keppner , Juergen Burger
发明人： Andreas Hogg , Yanik Tardy , Thierry Aellen , Herbert Keppner , Juergen Burger
CPC分类号： A61L31/10 , A61L2420/02 , A61N1/375 , Y10T428/239
摘要： Implantable medical devices, and methods of coating same, including a plurality of components disposed on a substrate, and a low surface energy layer deposited as a liquid over at least a first portion of the components and the substrate, the low surface energy layer becoming solidified after deposition and conforming to at least the first portion of the components. The devices further include a biocompatible hermetic coating conforming to and sealingly covering at least a portion of the low surface energy layer.
摘要翻译： 植入式医疗装置及其涂敷方法，包括设置在基板上的多个部件，以及在部件和基板的至少第一部分上作为液体沉积的低表面能层，低表面能层变得凝固 在沉积之后并且至少符合组件的第一部分。 这些装置还包括符合并密封地覆盖低表面能层的至少一部分的生物相容性密封涂层。
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公开(公告)号：US20110039050A1
公开(公告)日：2011-02-17
申请号：US12854298
申请日：2010-08-11
申请人： Andreas Hogg , Herbert Keppner , Thierry Aellen , Juergen Burger
发明人： Andreas Hogg , Herbert Keppner , Thierry Aellen , Juergen Burger
CPC分类号： A61N1/375 , H01L23/3121 , H01L2924/0002 , H05K3/284 , H05K2201/09872 , Y10T428/23 , Y10T428/239 , H01L2924/00
摘要： An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer coating applied by vapour deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in at least two sets, each set having first, second and third layers. At least one of the first, second and third layers consist essentially of a polymer such as parylene and at least one of the other two layers of the set consist essentially of inorganic material such that each layer differs in at least one diffusion barrier property from the other layers in the set and adds to an overall barrier effect of the coating.
摘要翻译： 一种可植入医疗装置，其包括在基底上的多个部件，以及通过气相沉积施加的生物相容性多层涂层以符合和密封地覆盖部件和/或基底的至少一部分。 涂层涂覆至少两组，每组具有第一层，第二层和第三层。 第一层，第二层和第三层中的至少一层基本上由聚合物如聚对二甲苯组成，并且该组的另外两层中的至少一层基本上由无机材料组成，使得每个层在至少一个扩散阻挡性质与 该组中的其它层并且增加了涂层的整体屏障效应。
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公开(公告)号：US08361591B2
公开(公告)日：2013-01-29
申请号：US12854320
申请日：2010-08-11
CPC分类号： A61N1/375 , A61L27/18 , A61L27/34 , A61L27/54 , A61L2300/608 , A61L2420/08 , Y10T428/23 , Y10T428/239 , C08L65/04
摘要： An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer coating applied at least in part by vapor deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in at least two sets of layers, wherein each set has at least one layer formed by dissociation of a polymeric precursor and then deposition of that precursor, and another layer is a biocompatible liquid.
摘要翻译： 一种植入式医疗装置，其包括在基底上的多个部件，以及生物相容的多层涂层，其至少部分地通过气相沉积施加以符合和密封地覆盖部件和/或基底的至少一部分。 将涂层涂覆在至少两组层中，其中每组具有通过解离聚合物前体形成的至少一层，然后沉积该前体，另一层是生物相容性液体。
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公开(公告)号：US20110038131A1
公开(公告)日：2011-02-17
申请号：US12854320
申请日：2010-08-11
CPC分类号： A61N1/375 , A61L27/18 , A61L27/34 , A61L27/54 , A61L2300/608 , A61L2420/08 , Y10T428/23 , Y10T428/239 , C08L65/04
摘要： An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer coating applied at least in part by vapour deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in at least two sets of layers, wherein each set has at least one layer formed by dissociation of a polymeric precursor and then deposition of that precursor, and another layer is a biocompatible liquid.
摘要翻译： 一种植入式医疗装置，其包括在基底上的多个部件，以及生物相容的多层涂层，其至少部分地通过气相沉积施加以符合和密封地覆盖部件和/或基底的至少一部分。 将涂层涂覆在至少两组层中，其中每组具有通过解离聚合物前体形成的至少一层，然后沉积该前体，另一层是生物相容性液体。
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公开(公告)号：US08313819B2
公开(公告)日：2012-11-20
申请号：US12854298
申请日：2010-08-11
申请人： Andreas Hogg , Herbert Keppner , Thierry Aellen , Juergen Burger
发明人： Andreas Hogg , Herbert Keppner , Thierry Aellen , Juergen Burger
CPC分类号： A61N1/375 , H01L23/3121 , H01L2924/0002 , H05K3/284 , H05K2201/09872 , Y10T428/23 , Y10T428/239 , H01L2924/00
摘要： An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer coating applied by vapor deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in at least two sets, each set having first, second and third layers. At least one of the first, second and third layers consist essentially of a polymer such as parylene and at least one of the other two layers of the set consist essentially of inorganic material such that each layer differs in at least one diffusion barrier property from the other layers in the set and adds to an overall barrier effect of the coating.
摘要翻译： 一种可植入医疗装置，其包括在基底上的多个部件，以及通过气相沉积施加的生物相容性多层涂层以符合和密封地覆盖部件和/或基底的至少一部分。 涂层涂覆至少两组，每组具有第一层，第二层和第三层。 第一层，第二层和第三层中的至少一层基本上由聚合物如聚对二甲苯组成，并且该组的另外两个层中的至少一层基本上由无机材料组成，使得每个层在至少一个扩散阻挡性质与 该组中的其它层并且增加了涂层的整体屏障效应。
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公开(公告)号：US08313811B2
公开(公告)日：2012-11-20
申请号：US12854304
申请日：2010-08-11
申请人： Andreas Hogg , Herbert Keppner , Thierry Aellen , Juergen Burger
发明人： Andreas Hogg , Herbert Keppner , Thierry Aellen , Juergen Burger
CPC分类号： A61N1/375 , A61N1/025 , A61N1/3758 , Y10T428/23 , Y10T428/239
摘要： An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer polymeric coating applied by vapor deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in at least two pairs of layers, wherein each pair has one layer formed by dissociation of a precursor and then simple deposition of that precursor, and the other layer is formed by at least one of plasma dissociation and excitation of the precursor to form a plasma-enhanced precursor, and then deposition of the plasma-enhanced precursor.
摘要翻译： 一种可植入医疗装置，其包括在基底上的多个部件，以及生物相容的多层聚合物涂层，其通过气相沉积施加以符合和密封地覆盖部件和/或基底的至少一部分。 涂层以至少两对层施加，其中每一对具有通过前体解离形成的一层，然后简单沉积该前体，另一层通过前体的等离子体解离和激发中的至少一种形成 以形成等离子体增强的前体，然后沉积等离子体增强的前体。
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公开(公告)号：US20110038130A1
公开(公告)日：2011-02-17
申请号：US12854304
申请日：2010-08-11
申请人： Andreas Hogg , Herbert Keppner , Thierry Aellen , Juergen Burger
发明人： Andreas Hogg , Herbert Keppner , Thierry Aellen , Juergen Burger
CPC分类号： A61N1/375 , A61N1/025 , A61N1/3758 , Y10T428/23 , Y10T428/239
摘要： An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer polymeric coating applied by vapour deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in at least two pairs of layers, wherein each pair has one layer formed by dissociation of a precursor and then simple deposition of that precursor, and the other layer is formed by at least one of plasma dissociation and excitation of the precursor to form a plasma-enhanced precursor, and then deposition of the plasma-enhanced precursor.
摘要翻译： 一种可植入医疗装置，其包括在基底上的多个部件，以及生物相容的多层聚合物涂层，其通过气相沉积施加以符合和密封地覆盖部件和/或基底的至少一部分。 涂层以至少两对层施加，其中每对具有通过解离前体形成的一层，然后简单沉积该前体，另一层通过前体的等离子体解离和激发中的至少一种形成 以形成等离子体增强的前体，然后沉积等离子体增强的前体。
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