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    HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    1.
    发明申请
    HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
    杂环化合物和使用方法

    公开(公告)号：US20070135502A1

    公开(公告)日：2007-06-14

    申请号：US11619936

    申请日：2007-01-04

    申请人： Andrew Bach ,  Prasad Kapa ,  George Lee ,  Eric Loeser ,  Michael Sabio ,  James Stanton ,  Thalaththani Vedananda

    发明人： Andrew Bach ,  Prasad Kapa ,  George Lee ,  Eric Loeser ,  Michael Sabio ,  James Stanton ,  Thalaththani Vedananda

    IPC分类号： A61K31/42 ,  A61K31/404 ,  A61K31/4025 ,  A61K31/401 ,  C07D413/02 ,  C07D411/02

    CPC分类号： C07D205/04 ,  C07D207/16 ,  C07D209/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

    摘要： Compounds of the formula provide pharmacological agents which are potent agonists of Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis and Crohn's disease. The compounds of the present invention are particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X. Preferred are the compounds of the invention which are dual agonists of PPARα and PPARγ receptors.

    摘要翻译： 配方的化合物提供作为过氧化物酶体增殖物激活受体（PPARs）的有效激动剂的药理学试剂。 因此，本发明的化合物可用于治疗由哺乳动物中的PPAR受体活性介导的病症。 这些病症包括血脂异常，高脂血症，高胆固醇血症，动脉粥样硬化，高甘油三酯血症，心力衰竭，心肌梗死，血管疾病，心血管疾病，高血压，肥胖症，炎症，关节炎，癌症，阿尔茨海默病，皮肤病，呼吸系统疾病，眼科疾病，炎症性肠病 ，溃疡性结肠炎和克罗恩病。 本发明的化合物在哺乳动物中特别可用作降血糖药，用于治疗和预防葡萄糖耐量降低，高血糖症和胰岛素抵抗等疾病，如1型和2型糖尿病，以及X综合征。 是本发明的化合物，它们是PPARα和PPARγ受体的双重激动剂。

    High storage volume support for displays
    4.
    发明授权
    High storage volume support for displays 有权
    高存储量支持显示器

    公开(公告)号：US06561469B1

    公开(公告)日：2003-05-13

    申请号：US10096778

    申请日：2002-03-12

    申请人： Kuni Masuda ,  Joe Miseli ,  James Stanton

    发明人： Kuni Masuda ,  Joe Miseli ,  James Stanton

    IPC分类号： F16M1100

    CPC分类号： F16M11/10 ,  F16M11/2021 ,  F16M2200/041 ,  G06F1/1601 ,  G06F2200/1612 ,  Y10S248/919

    摘要： The disclosed system is directed towards a high storage volume support system. The high storage volume support system includes an arched beam having a first end and a second end and a first base coupled to the first end. The high storage volume support system includes a second base coupled to the second end and a storage volume formed by the arched beam, the first base and the second base.

    摘要翻译： 所公开的系统针对高存储量支持系统。 高存储体积支撑系统包括具有第一端和第二端的拱形梁以及联接到第一端的第一基座。 高存储容积支持系统包括耦合到第二端的第二基座和由拱形梁，第一基座和第二基座形成的存储容积。

    Amide derivatives and their use as inhibitors of 11-beta-hydroxysteroid dehydrogenase type I
    5.
    发明申请
    Amide derivatives and their use as inhibitors of 11-beta-hydroxysteroid dehydrogenase type I 审中-公开
    酰胺衍生物及其作为I型11-β-羟基类固醇脱氢酶抑制剂的用途

    公开(公告)号：US20060205772A1

    公开(公告)日：2006-09-14

    申请号：US10542759

    申请日：2004-01-23

    申请人： Gary Coppola ,  Robert Damon ,  Paivi Kukkola ,  James Stanton

    发明人： Gary Coppola ,  Robert Damon ,  Paivi Kukkola ,  James Stanton

    IPC分类号： A61K31/4709 ,  C07D405/02 ,  C07D401/02 ,  C07D217/12 ,  C07D215/44

    CPC分类号： C07D213/82 ,  C07C235/40 ,  C07C235/46 ,  C07C237/30 ,  C07C237/42 ,  C07C237/44 ,  C07C255/57 ,  C07C271/28 ,  C07C275/42 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/74 ,  C07D209/46 ,  C07D215/08 ,  C07D217/06 ,  C07D223/16 ,  C07D265/36 ,  C07D307/68 ,  C07D317/62 ,  C07D317/68 ,  C07D333/38 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

    摘要： Compounds of the formula (I) provide pharmacological agents which lower intracellular glucocorticoid concentrations in mammals, in particular, intracellular cortisol levels in humans. Therefore, the compounds of the instant invention improve insulin sensitivity in the muscle and the adipose tissue, and reduce lipolysis and free fatty acid production in the adipose tissue. The compounds of the invention lower hepatic glucocorticoid concentration in mammals, in particular, hepatic cortisol concentration in humans, resulting in inhibition of hepatic gluconeogenesis and lowering of plasma glucose levels. Thus, the compounds of the instant invention may be particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which hyperglycemia and/or insulin resistance are implicated, such as type-2 diabetes. The compounds of the invention may also be used to treat other glucocorticoid associated disorders, such as Syndrome-X, dyslipidemia, hypertension and central obesity. The invention furthermore relates to the use of the compounds according to the invention for the preparation of medicaments, in particular of medicaments useful for the treatment and prevention of glucocorticoid associated disorders, by improving insulin sensitivity, reducing plasma glucose levels, reducing lipolysis and free fatty acid production, and by decreasing

    摘要翻译： 式（I）的化合物提供降低哺乳动物细胞内糖皮质激素浓度，特别是人体内细胞内皮质醇水平的药理学试剂。 因此，本发明的化合物可改善肌肉和脂肪组织中的胰岛素敏感性，并减少脂肪组织中的脂肪分解和游离脂肪酸的产生。 本发明的化合物在哺乳动物中具有较低的肝糖皮质激素浓度，特别是人类中的肝皮质醇浓度，导致肝脏糖异生的抑制和血浆葡萄糖水平的降低。 因此，本发明的化合物在哺乳动物中特别可用作降血糖药，用于治疗和预防涉及高血糖症和/或胰岛素抵抗的病症，例如2型糖尿病。 本发明的化合物还可用于治疗其它糖皮质激素相关疾病，例如综合征-X，血脂异常，高血压和中枢性肥胖。 本发明还涉及根据本发明的化合物用于制备药物，特别是可用于治疗和预防糖皮质激素相关疾病的药物，通过改善胰岛素敏感性，降低血浆葡萄糖水平，减少脂肪分解和游离脂肪 酸生产，并通过减少

    Surface aerator impeller design including stabilizer cylinder
    6.
    发明申请
    Surface aerator impeller design including stabilizer cylinder 审中-公开
    表面曝气机叶轮设计包括稳定缸

    公开(公告)号：US20090035150A1

    公开(公告)日：2009-02-05

    申请号：US12220957

    申请日：2008-07-30

    申请人： John R. McWhirter ,  Prakash G. Balan ,  James Stanton

    发明人： John R. McWhirter ,  Prakash G. Balan ,  James Stanton

    IPC分类号： F01D5/14

    CPC分类号： F01D5/028 ,  B01F3/04531 ,  B01F7/00466

    摘要： A surface aeration impeller incorporating a stabilizer cylinder that damps out and eliminates any sustained oscillatory or vibratory displacements normal to the axis of rotation when the impeller is in operation. The surface aeration design operates in a mechanically stable fashion under diverse loading conditions and at any static liquid level submergence of the impeller.

    摘要翻译： 一种表面曝气叶轮，其包括稳定器筒，当叶轮运行时，该稳定器缸体能够阻止并消除与旋转轴线垂直的任何持续振荡或振动位移。 表面曝气设计在不同的负载条件下和在叶轮的任何静态液位淹没下以机械稳定的方式工作。

    Universal support system for displays
    8.
    发明授权
    Universal support system for displays 有权
    通用显示支持系统

    公开(公告)号：US06575419B1

    公开(公告)日：2003-06-10

    申请号：US10097240

    申请日：2002-03-12

    申请人： Kuni Masuda ,  Joe Miseli ,  James Stanton

    发明人： Kuni Masuda ,  Joe Miseli ,  James Stanton

    IPC分类号： A47G2900

    CPC分类号： F16M11/10 ,  F16M11/2021 ,  F16M2200/041 ,  G06F1/1601 ,  G06F2200/1612 ,  Y10S248/922 ,  Y10S248/923 ,  Y10T16/5403

    摘要： The disclosed system is directed towards a universal support system. The universal support system comprises a pair of arched bases and an arched beam coupled to the pair of arched bases. The universal support system also includes a multi-hinge rotatably coupled to the arched beam and a mounting bracket rotatably coupled to the multi-hinge, wherein the mounting bracket conforms with a mounting bracket standard for mounting displays.

    摘要翻译： 所公开的系统针对通用支持系统。 通用支撑系统包括一对拱形基座和耦合到该对拱形基座的拱形梁。 通用支撑系统还包括可旋转地联接到拱形梁的多铰链和可旋转地联接到多铰链的安装支架，其中安装支架符合用于安装显示器的安装支架标准。