公开(公告)号：US20110064819A1

公开(公告)日：2011-03-17

申请号：US12991543

申请日：2009-05-05

申请人： Andrew Beaton ,  Ian Richard Catchpole ,  Gerald Wayne Gough ,  Irene Papanicolaou

发明人： Andrew Beaton ,  Ian Richard Catchpole ,  Gerald Wayne Gough ,  Irene Papanicolaou

IPC分类号： A61K9/14 ,  A61K39/395 ,  A61P35/00 ,  A61P25/28 ,  B82Y5/00

CPC分类号： A61K9/5138 ,  A61K9/0019 ,  A61K9/0051 ,  A61K9/0085 ,  A61K9/1647 ,  A61K9/5153 ,  A61K9/5192 ,  A61K2039/505

摘要： The present invention provides methods of encapsulating biologically active agents such as proteins in particulate carriers such as nanoparticles using Hip agents. Also provided are compositions comprising particulate carriers obtainable by such methods and uses of such compositions in treatment.

摘要翻译： 本发明提供了使用Hip剂将生物活性剂如蛋白质包封在颗粒载体如纳米颗粒中的方法。 还提供了包含可通过这些方法和这些组合物在处理中的用途获得的颗粒载体的组合物。

公开(公告)号：US20120058116A1

公开(公告)日：2012-03-08

申请号：US13265887

申请日：2010-04-22

申请人： Andrew Beaton ,  Sean Matthew Cleveland ,  Gerald Wayne Gough ,  Mark Andrew Paulik

发明人： Andrew Beaton ,  Sean Matthew Cleveland ,  Gerald Wayne Gough ,  Mark Andrew Paulik

IPC分类号： A61K39/395 ,  A61P1/00 ,  A61P3/00 ,  C07K19/00 ,  A61P3/04

CPC分类号： C07K16/2863 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/32

摘要： The invention relates to combinations of FGFR1c antagonists with agonist peptides and provide dual targeting proteins which bind to FEFR1c comprising an antigen binding protein which is capable of binding to FGFR1c and which is linked to one or more agonist peptides, methods of making such constructs and uses thereof, particularly in treating obesity.

摘要翻译： 本发明涉及FGFR1c拮抗剂与激动剂肽的组合，并提供与FEFR1c结合的双重靶向蛋白，其包含能够结合FGFR1c并与一种或多种激动剂肽连接的抗原结合蛋白，制备此类构建体和用途的方法 ，特别是治疗肥胖症。

公开(公告)号：US09150651B2

公开(公告)日：2015-10-06

申请号：US13978228

申请日：2012-01-04

申请人： Andrew Beaton ,  Caroline Dimech ,  Peter Franz Ertl ,  Susannah Karen Ford ,  Ruth Mcadam

发明人： Andrew Beaton ,  Caroline Dimech ,  Peter Franz Ertl ,  Susannah Karen Ford ,  Ruth Mcadam

IPC分类号： C07K16/28

CPC分类号： C07K16/2863 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C12N1/00 ,  C12N15/09

摘要： The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.

摘要翻译： 本公开提供了抗TGFbetaRII免疫球蛋白单可变结构域。 适当地，根据本公开内容的抗TGFbetaRII免疫球蛋白单可变结构域是具有SEQ ID NO：1-28中任一项所述的具有多达5个氨基酸取代，缺失或添加的氨基酸序列的抗TGFbetaRII免疫球蛋白单可变结构域。 本公开进一步提供了用于治疗与TGFbeta信号传导相关疾病的合适的多肽和药物组合物，并适当地选自以下组中的疾病：组织纤维化，例如肺纤维化，包括特发性肺纤维化; 肝纤维化，包括肝硬化和慢性肝炎; 类风湿关节炎; 眼部疾病; 皮肤纤维化，包括皮肤瘢痕疙瘩; Dupuytren的挛缩 肾纤维化如肾炎和肾硬化; 伤口愈合; 疤痕减少 和血管病变，如再狭窄。

公开(公告)号：US20130302335A1

公开(公告)日：2013-11-14

申请号：US13978228

申请日：2012-01-04

申请人： Andrew Beaton ,  Caroline Dimech ,  Peter Franz Ertl ,  Susannah Karen Ford ,  Ruth Mcadam

发明人： Andrew Beaton ,  Caroline Dimech ,  Peter Franz Ertl ,  Susannah Karen Ford ,  Ruth Mcadam

IPC分类号： C07K16/28

CPC分类号： C07K16/2863 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C12N1/00 ,  C12N15/09

摘要： The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.

公开(公告)号：US20110256132A1

公开(公告)日：2011-10-20

申请号：US13140841

申请日：2009-12-18

申请人： Claire Ashman ,  Andrew Beaton ,  Jonathan Henry Ellis ,  Baijin Han ,  Ian Kirby ,  Frederick Kull ,  Alan Lewis ,  Kathryn Mason Lindley ,  Martin Anibal Orecchia ,  Ying Shen ,  Paul Wilson ,  Tian Shun Xun ,  Hong Zhang

发明人： Claire Ashman ,  Andrew Beaton ,  Jonathan Henry Ellis ,  Baijin Han ,  Ian Kirby ,  Frederick Kull ,  Alan Lewis ,  Kathryn Mason Lindley ,  Martin Anibal Orecchia ,  Ying Shen ,  Paul Wilson ,  Tian Shun Xun ,  Hong Zhang

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12N1/00 ,  C12P21/02 ,  A61P21/00 ,  A61P31/18 ,  A61P35/00 ,  A61P17/02 ,  A61P25/00 ,  A61P19/08 ,  A61P3/10 ,  A61P3/04 ,  A61P19/02 ,  A61P13/12 ,  A61P9/04 ,  A61P25/28 ,  A61P25/16 ,  A61P19/10 ,  A61P1/16 ,  A61P43/00 ,  C07K16/22

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92

摘要： Description of antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. Furthermore, description of the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with anyone or a combination of decreased muscle mass, muscle strength and muscle function.

摘要翻译： 描述结合肌生长抑素的抗体结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物及其制备方法。 此外，描述了这种抗原结合蛋白在治疗或预防与任何人相关的疾病或肌肉力量和肌肉功能下降的组合中的用途。

公开(公告)号：US20070015721A1

公开(公告)日：2007-01-18

申请号：US10490011

申请日：2002-09-18

申请人： Andrew Beaton ,  Peter Ertl ,  Gerald Gough ,  Andrew Lear ,  John Tite ,  Catherine Van Wely

发明人： Andrew Beaton ,  Peter Ertl ,  Gerald Gough ,  Andrew Lear ,  John Tite ,  Catherine Van Wely

IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/86

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  C07K14/005 ,  C07K2319/00 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2740/16334

摘要： The invention provides a nucleotide sequence that encodes an HIV-1 gag protein or fragment thereof containing a gag epitope and a second HIV antigen or a fragment encoding an epitope of said second HIV antigen, operably linked to a heterologous promoter. Preferred polynucleotide sequences further encodes nef or a fragment thereof and RT or a fragment thereof.

摘要翻译： 本发明提供编码HIV-1gag蛋白或其片段的核苷酸序列，其含有gag表位和第二HIV抗原或编码所述第二HIV抗原表位的片段，其可操作地连接到异源启动子。 优选的多核苷酸序列进一步编码nef或其片段和RT或其片段。