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公开(公告)号：US20110064819A1
公开(公告)日：2011-03-17
申请号：US12991543
申请日：2009-05-05
IPC分类号： A61K9/14 , A61K39/395 , A61P35/00 , A61P25/28 , B82Y5/00
CPC分类号： A61K9/5138 , A61K9/0019 , A61K9/0051 , A61K9/0085 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K2039/505
摘要： The present invention provides methods of encapsulating biologically active agents such as proteins in particulate carriers such as nanoparticles using Hip agents. Also provided are compositions comprising particulate carriers obtainable by such methods and uses of such compositions in treatment.
摘要翻译： 本发明提供了使用Hip剂将生物活性剂如蛋白质包封在颗粒载体如纳米颗粒中的方法。 还提供了包含可通过这些方法和这些组合物在处理中的用途获得的颗粒载体的组合物。
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公开(公告)号：US20110064821A1
公开(公告)日：2011-03-17
申请号：US12991556
申请日：2009-05-05
IPC分类号： A61K9/14 , A61K38/16 , A61K39/395 , A61P27/02 , B82Y5/00
CPC分类号： A61K9/5138 , A61K9/0051 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K2039/505 , Y02A50/394
摘要： The present invention provides methods of encapsulating biologically active agents such as proteins in particulate carriers such as nanoparticles. Also provided are methods of delivery of proteins across the blood brain barrier in nanoparticles, and uses of such compositions in treatment.
摘要翻译： 本发明提供了将生物活性剂如蛋白质包封在颗粒载体如纳米颗粒中的方法。 还提供了在纳米颗粒中通过血脑屏障传递蛋白质的方法，以及这些组合物在治疗中的用途。
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公开(公告)号：US20110014182A1
公开(公告)日：2011-01-20
申请号：US12746837
申请日：2008-12-09
申请人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , A61P25/28 , A61K38/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
摘要翻译： 结合β-淀粉样蛋白肽，特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法，其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物，特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成，具有所述抗原结合蛋白; 包含所述抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号：US08921523B2
公开(公告)日：2014-12-30
申请号：US12330541
申请日：2008-12-09
申请人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Gerald Wayne Gough , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Gerald Wayne Gough , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号： C07K16/46 , C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with the antigen binding proteins; pharmaceutical compositions comprising the antigen binding proteins; and methods of manufacture.
摘要翻译： 结合β-淀粉样蛋白肽，特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法，其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物，特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成，与抗原结合蛋白; 包含抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号：US20110045027A1
公开(公告)日：2011-02-24
申请号：US11917961
申请日：2006-06-20
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55577 , C12N2710/10343 , C12N2740/16034
摘要： The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof.
摘要翻译： 本发明提供了用于多核苷酸疫苗的新型佐剂，特别是本发明提供了包含编码能够引发免疫应答的抗原的多核苷酸的免疫原性组合物和包含免疫刺激量的双子表面活性剂或其衍生物的佐剂。
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公开(公告)号：US08858943B2
公开(公告)日：2014-10-14
申请号：US12679917
申请日：2008-09-23
申请人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号： A61K39/395 , A61K35/30 , A61K35/44 , C07K16/18 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
摘要： The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
摘要翻译： 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，特别是年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成， 具有结合β-淀粉样蛋白肽的特异性抗原结合蛋白，特别是人和淀粉样蛋白肽。
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公开(公告)号：US20110064740A1
公开(公告)日：2011-03-17
申请号：US12679917
申请日：2008-09-23
申请人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号： A61K39/395 , C07K16/00 , A61P27/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
摘要： The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
摘要翻译： 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，特别是年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成， 具有结合β-淀粉样蛋白肽的特异性抗原结合蛋白，特别是人和淀粉样蛋白肽。
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公开(公告)号：US20140205604A1
公开(公告)日：2014-07-24
申请号：US14235330
申请日：2012-07-25
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/54 , A61K2039/70 , C07K16/46 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD). diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.
摘要翻译： 本发明涉及包含由抗体的单链Fc区分离的一个或两个表位结合结构域的抗原结合构建体，其中能够结合VEGF的每个表位结合域与包含本发明的两个抗原结合构建体的二聚体， 包含所述二聚体的药物组合物及其用于治疗与VEGF信号传导相关的疾病，例如糖尿病性黄斑水肿（DME），湿性年龄相关性黄斑变性（湿性AMD）的用途。 糖尿病性视网膜病变，视网膜静脉阻塞（RVO）和角膜新生血管形成，以及编码所述抗原结合构建体的多核苷酸序列。
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公开(公告)号：US09499612B2
公开(公告)日：2016-11-22
申请号：US14235330
申请日：2012-07-25
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/54 , A61K2039/70 , C07K16/46 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularization, and polynucleotide sequences encoding said antigen binding constructs.
摘要翻译： 本发明涉及包含由抗体的单链Fc区分离的一个或两个表位结合结构域的抗原结合构建体，其中能够结合VEGF的每个表位结合域与包含本发明的两个抗原结合构建体的二聚体， 包含所述二聚体的药物组合物及其用于治疗与VEGF信号传导相关的疾病，例如糖尿病性黄斑水肿（DME），湿性年龄相关性黄斑变性（湿性AMD），糖尿病性视网膜病变，视网膜静脉阻塞（RVO）和角膜 新生血管形成和编码所述抗原结合构建体的多核苷酸序列。
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公开(公告)号：US20110256122A1
公开(公告)日：2011-10-20
申请号：US13130656
申请日：2009-11-04
IPC分类号： A61K39/395 , C07K16/22 , C07K16/18 , A61P27/04 , C07K16/24 , C07K16/46 , A61P27/02 , A61P27/06 , C07K16/00 , C07K16/28
CPC分类号： C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The present disclosure relates to immunoglobulin single variable domains (dAbs) e.g., dAbs which are protease resistant, and also to formulations, and compositions comprising such dAbs for ocular delivery and to their uses to treat ocular diseases and conditions.
摘要翻译： 本公开涉及免疫球蛋白单可变结构域（dAb），例如蛋白酶抗性的dAb，还涉及制剂，以及包含用于眼部递送的这种dAb的组合物及其用于治疗眼部疾病和病症的组合物。
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