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公开(公告)号：US20110256132A1
公开(公告)日：2011-10-20
申请号：US13140841
申请日：2009-12-18
申请人： Claire Ashman , Andrew Beaton , Jonathan Henry Ellis , Baijin Han , Ian Kirby , Frederick Kull , Alan Lewis , Kathryn Mason Lindley , Martin Anibal Orecchia , Ying Shen , Paul Wilson , Tian Shun Xun , Hong Zhang
发明人： Claire Ashman , Andrew Beaton , Jonathan Henry Ellis , Baijin Han , Ian Kirby , Frederick Kull , Alan Lewis , Kathryn Mason Lindley , Martin Anibal Orecchia , Ying Shen , Paul Wilson , Tian Shun Xun , Hong Zhang
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P21/00 , A61P31/18 , A61P35/00 , A61P17/02 , A61P25/00 , A61P19/08 , A61P3/10 , A61P3/04 , A61P19/02 , A61P13/12 , A61P9/04 , A61P25/28 , A61P25/16 , A61P19/10 , A61P1/16 , A61P43/00 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Description of antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. Furthermore, description of the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with anyone or a combination of decreased muscle mass, muscle strength and muscle function.
摘要翻译： 描述结合肌生长抑素的抗体结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物及其制备方法。 此外，描述了这种抗原结合蛋白在治疗或预防与任何人相关的疾病或肌肉力量和肌肉功能下降的组合中的用途。
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公开(公告)号：US20110008345A1
公开(公告)日：2011-01-13
申请号：US12744799
申请日：2008-11-28
申请人： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
发明人： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N5/10 , C12P21/04 , A61P35/00 , A61P11/06 , A61P19/02
CPC分类号： C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US20090148905A1
公开(公告)日：2009-06-11
申请号：US12324905
申请日：2008-11-28
申请人： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
发明人： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC分类号： C12P21/02 , C07K16/00 , C07H21/00 , A61K39/395 , C12N5/10
CPC分类号： C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US08680245B2
公开(公告)日：2014-03-25
申请号：US13321982
申请日：2010-05-26
申请人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
发明人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
摘要翻译： 本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在 治疗和/或预防炎性疾病如哮喘或IPF。
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公开(公告)号：US20120082682A1
公开(公告)日：2012-04-05
申请号：US13321982
申请日：2010-05-26
申请人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
发明人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
摘要翻译： 本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在 治疗和/或预防炎性疾病如哮喘或IPF。
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公开(公告)号：US20130142788A1
公开(公告)日：2013-06-06
申请号：US13699013
申请日：2011-06-02
申请人： Claire Ashman , Stephen Ashman , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
发明人： Claire Ashman , Stephen Ashman , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanised antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such humanised antigen binding proteins in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.
摘要翻译： 本发明涉及结合肌生成抑制素的人源化抗原结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物及其制备方法。 本发明还涉及这样的人源化抗原结合蛋白在治疗或预防与肌肉量，肌肉力量和肌肉功能降低的任何一种或组合相关的疾病中的用途。
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公开(公告)号：US20120070439A1
公开(公告)日：2012-03-22
申请号：US13322224
申请日：2010-05-26
CPC分类号： C07K16/468 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2318/20 , C07K2319/30
摘要： The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.
摘要翻译： 本发明涉及适用于抗原结合蛋白的接头，某些抗原结合蛋白及其制备方法。
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公开(公告)号：US09394374B2
公开(公告)日：2016-07-19
申请号：US13322224
申请日：2010-05-26
CPC分类号： C07K16/468 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2318/20 , C07K2319/30
摘要： The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.
摘要翻译： 本发明涉及适用于抗原结合蛋白的接头，某些抗原结合蛋白及其制备方法。
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