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公开(公告)号：US20110256132A1
公开(公告)日：2011-10-20
申请号：US13140841
申请日：2009-12-18
申请人： Claire Ashman , Andrew Beaton , Jonathan Henry Ellis , Baijin Han , Ian Kirby , Frederick Kull , Alan Lewis , Kathryn Mason Lindley , Martin Anibal Orecchia , Ying Shen , Paul Wilson , Tian Shun Xun , Hong Zhang
发明人： Claire Ashman , Andrew Beaton , Jonathan Henry Ellis , Baijin Han , Ian Kirby , Frederick Kull , Alan Lewis , Kathryn Mason Lindley , Martin Anibal Orecchia , Ying Shen , Paul Wilson , Tian Shun Xun , Hong Zhang
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P21/00 , A61P31/18 , A61P35/00 , A61P17/02 , A61P25/00 , A61P19/08 , A61P3/10 , A61P3/04 , A61P19/02 , A61P13/12 , A61P9/04 , A61P25/28 , A61P25/16 , A61P19/10 , A61P1/16 , A61P43/00 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Description of antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. Furthermore, description of the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with anyone or a combination of decreased muscle mass, muscle strength and muscle function.
摘要翻译： 描述结合肌生长抑素的抗体结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物及其制备方法。 此外，描述了这种抗原结合蛋白在治疗或预防与任何人相关的疾病或肌肉力量和肌肉功能下降的组合中的用途。
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公开(公告)号：US20110008345A1
公开(公告)日：2011-01-13
申请号：US12744799
申请日：2008-11-28
申请人： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
发明人： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N5/10 , C12P21/04 , A61P35/00 , A61P11/06 , A61P19/02
CPC分类号： C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US20090148905A1
公开(公告)日：2009-06-11
申请号：US12324905
申请日：2008-11-28
申请人： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
发明人： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC分类号： C12P21/02 , C07K16/00 , C07H21/00 , A61K39/395 , C12N5/10
CPC分类号： C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US08680245B2
公开(公告)日：2014-03-25
申请号：US13321982
申请日：2010-05-26
申请人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
发明人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
摘要翻译： 本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在 治疗和/或预防炎性疾病如哮喘或IPF。
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公开(公告)号：US20120082682A1
公开(公告)日：2012-04-05
申请号：US13321982
申请日：2010-05-26
申请人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
发明人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
摘要翻译： 本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在 治疗和/或预防炎性疾病如哮喘或IPF。
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6.发明授权公开(公告)号：US07807788B2
公开(公告)日：2010-10-05
申请号：US11570736
申请日：2005-06-30
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention concerns immunoglobulins, particularly antibodies which specifically bind human Interleukin 13 (hIL-13). Antibodies of the invention may be used in the treatment of a variety of diseases or disorders responsive to modulation of the interaction between hIL-13 and the human IL-13 receptor. Such diseases include severe asthma, atopic dermatitis, COPD and various fibrotic diseases. Pharmaceutical compositions comprising said antibodies and methods of manufacture are also disclosed.
摘要翻译： 本发明涉及免疫球蛋白，特别是特异性结合人白细胞介素13（hIL-13）的抗体。 本发明的抗体可用于治疗响应调节hIL-13与人IL-13受体之间的相互作用的各种疾病或病症。 这些疾病包括严重哮喘，特应性皮炎，COPD和各种纤维化疾病。 还公开了包含所述抗体和制备方法的药物组合物。
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公开(公告)号：US20120100137A1
公开(公告)日：2012-04-26
申请号：US13315358
申请日：2011-12-09
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K39/00 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example surface plasmon resonance to identify antibodies with therapeutic potential.
摘要翻译： 本发明公开了人源化抗IL-18抗体，制备方法和用所述抗体治疗的方法。 还公开了使用例如表面等离子体共振以鉴定具有治疗潜力的抗体的筛选方法。
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公开(公告)号：US08637018B2
公开(公告)日：2014-01-28
申请号：US13315358
申请日：2011-12-09
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K39/00 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example surface plasmon resonance to identify antibodies with therapeutic potential.
摘要翻译： 本发明公开了人源化抗IL-18抗体，制备方法和用所述抗体治疗的方法。 还公开了使用例如表面等离子体共振以鉴定具有治疗潜力的抗体的筛选方法。
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公开(公告)号：US08362208B2
公开(公告)日：2013-01-29
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K17/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20100047243A1
公开(公告)日：2010-02-25
申请号：US12526966
申请日：2008-02-12
申请人： Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
发明人： Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
IPC分类号： A61K39/395 , C07K16/00 , C12N5/10 , C12P21/04
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-1R, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.
摘要翻译： 本发明涉及特异性结合IGF-1R，特别是hIGF-1R的抗体或其抗原结合片段。 还公开了包含本发明的抗体或抗原结合片段的抗体制剂。 生产此类抗体或抗原结合片段的方法及其用途也包括在本发明的范围内。
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