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公开(公告)号:US20130302399A1
公开(公告)日:2013-11-14
申请号:US13795674
申请日:2013-03-12
申请人: Andrew Lawrence Feldhaus , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Ethan Wayne Ojala , Brian Robert Kovacevich , Katie Olson , Pei Fan , Jens Billgren , Erica Ann Stewart , Corinne C. Akatsuka , Patricia Dianne McNeill , Danielle Marie Mitchell , Dan Scott Allison , John A. Latham
发明人: Andrew Lawrence Feldhaus , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Ethan Wayne Ojala , Brian Robert Kovacevich , Katie Olson , Pei Fan , Jens Billgren , Erica Ann Stewart , Corinne C. Akatsuka , Patricia Dianne McNeill , Danielle Marie Mitchell , Dan Scott Allison , John A. Latham
IPC分类号: C07K16/40 , A61K45/06 , A61K39/395
CPC分类号: C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96433
摘要: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.
摘要翻译: 本发明涉及对PCSK9具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段,其包含本文所述的VH,VL和CDR多肽的序列,以及编码它们的多核苷酸。 本发明还考虑了抗PCSK9抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗PCSK9抗体及其结合片段的方法。 本发明的实施方案还涉及抗PCSK9抗体及其结合片段用于诊断,评估和治疗与PCSK9相关的疾病和病症的用途。
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公开(公告)号:US20130336975A1
公开(公告)日:2013-12-19
申请号:US13833338
申请日:2013-03-15
申请人: Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人: Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号: C07K16/22
CPC分类号: C07K16/22 , A61K39/3955 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/94
摘要: The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
摘要翻译: 本发明涉及对NGF具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段,其包含本文所述的VH,VL和CDR多肽的序列,以及编码它们的多核苷酸。 本发明还考虑了抗NGF抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗NGF抗体及其结合片段的方法。 本发明的实施方案还涉及抗NGF抗体及其结合片段用于诊断,评估和治疗与NGF相关的疾病和病症的用途。
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公开(公告)号:US09499611B2
公开(公告)日:2016-11-22
申请号:US13309295
申请日:2011-12-01
申请人: Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人: Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号: A61K39/395 , C07K16/22 , C07K16/28 , A61K45/06 , A61K39/00
摘要: The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
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公开(公告)号:US09783602B2
公开(公告)日:2017-10-10
申请号:US13309295
申请日:2011-12-01
申请人: Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人: Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号: A61K39/395 , C07K16/22 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要: The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
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公开(公告)号:US09745373B2
公开(公告)日:2017-08-29
申请号:US13476465
申请日:2012-05-21
申请人: Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
发明人: Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
CPC分类号: C07K16/18 , A61K31/485 , A61K39/3955 , A61K49/00 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要: The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
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公开(公告)号:US20120294797A1
公开(公告)日:2012-11-22
申请号:US13476465
申请日:2012-05-21
申请人: Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
发明人: Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
IPC分类号: C07K16/18 , C12N15/63 , C12N1/19 , A61K39/395 , A61K49/00 , A61K51/00 , C12Q1/68 , C12N5/10 , C12N1/15 , C12N1/21 , A61P25/06 , A61P3/00 , A61P35/00 , A61P25/00 , A61P29/00 , A61P19/08 , A61P1/16 , A61P13/12 , A61P13/00 , A61P3/10 , A61P37/00 , A61P9/00 , A61P19/02 , A61P11/00 , A61P11/06 , A61P25/36 , A61P15/00 , A61P17/00 , A61P17/06 , A61P25/08 , A61P25/28 , A61P17/04 , A61P1/00 , A61P37/08 , A61P31/00 , C12N15/13
CPC分类号: C07K16/18 , A61K31/485 , A61K39/3955 , A61K49/00 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要: The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
摘要翻译: 本发明涉及对CGRP具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段,其包含本文所述的VH,VL和CDR多肽的序列,以及编码它们的多核苷酸。 本发明还考虑了抗CGRP抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗CGRP抗体及其结合片段的方法。 本发明的实施方案还涉及抗CGRP抗体及其结合片段用于诊断,评估和治疗与CGRP相关的疾病和病症的用途。
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公开(公告)号:US20120148490A1
公开(公告)日:2012-06-14
申请号:US13309295
申请日:2011-12-01
申请人: Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne NcNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人: Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne NcNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号: A61K39/395 , C12N15/13 , A61K49/00 , A61K51/10 , A61P29/00 , A61P25/00 , A61P19/10 , A61P35/00 , A61P1/16 , A61P25/06 , A61P31/04 , A61P21/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N9/96 , C12P21/02 , A61P37/08 , C07K16/22
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要: The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
摘要翻译: 本发明涉及对NGF具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段,其包含本文所述的VH,VL和CDR多肽的序列,以及编码它们的多核苷酸。 本发明还考虑了抗NGF抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗NGF抗体及其结合片段的方法。 本发明的实施方案还涉及抗NGF抗体及其结合片段用于诊断,评估和治疗与NGF相关的疾病和病症的用途。
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8.
公开(公告)号:US20140004116A1
公开(公告)日:2014-01-02
申请号:US13834889
申请日:2013-03-15
申请人: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
发明人: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
IPC分类号: C07K16/22 , A61K45/06 , A61K39/395
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/32 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/76
摘要: Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
摘要翻译: 具有对人神经生长因子(NGF)具有结合特异性的抗体及其抗体片段以及用于治疗疼痛的方法。 治疗疼痛或引起镇痛作用的方法包括施用有效量的抑制NGF与TrkA缔合的抗人NGF抗体或其抗体片段和/或p75。 这些方法可以任选地进一步包括施用有效量的第二抗人NGF抗体或其片段(例如,抑制NGF与p75缔合的抑制剂或抑制NGF与TrkA缔合的抑制剂)。
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9.
公开(公告)号:US08728473B2
公开(公告)日:2014-05-20
申请号:US13309153
申请日:2011-12-01
申请人: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T. L. Smith , Benjamin H. Dutzar
发明人: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T. L. Smith , Benjamin H. Dutzar
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要: Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
摘要翻译: 具有对人神经生长因子(NGF)具有结合特异性的抗体及其抗体片段以及用于治疗疼痛的方法。 治疗疼痛或引起镇痛作用的方法包括施用有效量的抑制NGF与TrkA缔合的抗人NGF抗体或其抗体片段和/或p75。 这些方法可以任选地进一步包括施用有效量的第二抗人NGF抗体或其片段(例如,抑制NGF与p75缔合的抑制剂或抑制NGF与TrkA缔合的抑制剂)。
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10.
公开(公告)号:US20120141485A1
公开(公告)日:2012-06-07
申请号:US13309153
申请日:2011-12-01
申请人: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
发明人: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
IPC分类号: A61K39/395 , A61P25/04 , A61K39/00 , A61P25/00 , B82Y5/00
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要: Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
摘要翻译: 具有对人神经生长因子(NGF)具有结合特异性的抗体及其抗体片段以及用于治疗疼痛的方法。 治疗疼痛或引起镇痛作用的方法包括施用有效量的抑制NGF与TrkA缔合的抗人NGF抗体或其抗体片段和/或p75。 这些方法可以任选地进一步包括施用有效量的第二抗人NGF抗体或其片段(例如,抑制NGF与p75缔合的抑制剂或抑制NGF与TrkA缔合的抑制剂)。
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