公开(公告)号：US20120148490A1

公开(公告)日：2012-06-14

申请号：US13309295

申请日：2011-12-01

申请人： Benjamin H. Dutzar ,  Brian R. Kovacevich ,  Patricia Dianne NcNeill ,  Danielle M. Mitchell ,  Ethan W. Ojala ,  Pei Fan ,  Jens Billgren ,  Erica A. Stewart ,  Corinne C. Akatsuka ,  Betty Yu-Ching Chang ,  John A. Latham ,  Leon F. Garcia-Martinez

发明人： Benjamin H. Dutzar ,  Brian R. Kovacevich ,  Patricia Dianne NcNeill ,  Danielle M. Mitchell ,  Ethan W. Ojala ,  Pei Fan ,  Jens Billgren ,  Erica A. Stewart ,  Corinne C. Akatsuka ,  Betty Yu-Ching Chang ,  John A. Latham ,  Leon F. Garcia-Martinez

IPC分类号： A61K39/395 ,  C12N15/13 ,  A61K49/00 ,  A61K51/10 ,  A61P29/00 ,  A61P25/00 ,  A61P19/10 ,  A61P35/00 ,  A61P1/16 ,  A61P25/06 ,  A61P31/04 ,  A61P21/00 ,  C12N15/63 ,  C12N5/10 ,  C12N1/21 ,  C12N1/15 ,  C12N1/19 ,  C12N9/96 ,  C12P21/02 ,  A61P37/08 ,  C07K16/22

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/2875 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

摘要翻译： 本发明涉及对NGF具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还考虑了抗NGF抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗NGF抗体及其结合片段的方法。 本发明的实施方案还涉及抗NGF抗体及其结合片段用于诊断，评估和治疗与NGF相关的疾病和病症的用途。

公开(公告)号：US20130336975A1

公开(公告)日：2013-12-19

申请号：US13833338

申请日：2013-03-15

申请人： Benjamin H. Dutzar ,  Brian R. Kovacevich ,  Patricia Dianne McNeill ,  Danielle M. Mitchell ,  Ethan W. Ojala ,  Pei Fan ,  Jens Billgren ,  Erica A. Stewart ,  Corinne C. Akatsuka ,  Betty Yu-Ching Chang ,  John A. Latham ,  Leon F. Garcia-Martinez

发明人： Benjamin H. Dutzar ,  Brian R. Kovacevich ,  Patricia Dianne McNeill ,  Danielle M. Mitchell ,  Ethan W. Ojala ,  Pei Fan ,  Jens Billgren ,  Erica A. Stewart ,  Corinne C. Akatsuka ,  Betty Yu-Ching Chang ,  John A. Latham ,  Leon F. Garcia-Martinez

IPC分类号： C07K16/22

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/2875 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/94

摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

摘要翻译： 本发明涉及对NGF具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还考虑了抗NGF抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗NGF抗体及其结合片段的方法。 本发明的实施方案还涉及抗NGF抗体及其结合片段用于诊断，评估和治疗与NGF相关的疾病和病症的用途。

公开(公告)号：US09499611B2

公开(公告)日：2016-11-22

申请号：US13309295

申请日：2011-12-01

申请人： Benjamin H. Dutzar ,  Brian R. Kovacevich ,  Patricia Dianne McNeill ,  Danielle M. Mitchell ,  Ethan W. Ojala ,  Pei Fan ,  Jens Billgren ,  Erica A. Stewart ,  Corinne C. Akatsuka ,  Betty Yu-Ching Chang ,  John A. Latham ,  Leon F. Garcia-Martinez

发明人： Benjamin H. Dutzar ,  Brian R. Kovacevich ,  Patricia Dianne McNeill ,  Danielle M. Mitchell ,  Ethan W. Ojala ,  Pei Fan ,  Jens Billgren ,  Erica A. Stewart ,  Corinne C. Akatsuka ,  Betty Yu-Ching Chang ,  John A. Latham ,  Leon F. Garcia-Martinez

IPC分类号： A61K39/395 ,  C07K16/22 ,  C07K16/28 ,  A61K45/06 ,  A61K39/00

摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

公开(公告)号：US09783602B2

公开(公告)日：2017-10-10

申请号：US13309295

申请日：2011-12-01

申请人： Benjamin H. Dutzar ,  Brian R. Kovacevich ,  Patricia Dianne McNeill ,  Danielle M. Mitchell ,  Ethan W. Ojala ,  Pei Fan ,  Jens Billgren ,  Erica A. Stewart ,  Corinne C. Akatsuka ,  Betty Yu-Ching Chang ,  John A. Latham ,  Leon F. Garcia-Martinez

发明人： Benjamin H. Dutzar ,  Brian R. Kovacevich ,  Patricia Dianne McNeill ,  Danielle M. Mitchell ,  Ethan W. Ojala ,  Pei Fan ,  Jens Billgren ,  Erica A. Stewart ,  Corinne C. Akatsuka ,  Betty Yu-Ching Chang ,  John A. Latham ,  Leon F. Garcia-Martinez

IPC分类号： A61K39/395 ,  C07K16/22 ,  A61K45/06 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/2875 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

公开(公告)号：US20130224201A1

公开(公告)日：2013-08-29

申请号：US13682214

申请日：2012-11-20

申请人： Leon F. Garcia-Martinez ,  Ann Elisabeth Carvalho-Jensen ,  Katie Olson ,  Benjamin H. Dutzar ,  Ethan W. Ojala ,  Brian R. Kovacevich ,  John A. Latham ,  Jeffrey T.L. Smith

发明人： Leon F. Garcia-Martinez ,  Ann Elisabeth Carvalho-Jensen ,  Katie Olson ,  Benjamin H. Dutzar ,  Ethan W. Ojala ,  Brian R. Kovacevich ,  John A. Latham ,  Jeffrey T.L. Smith

IPC分类号： C07K16/18 ,  A61K45/06 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/39533 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/412

摘要： The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.

摘要翻译： 本发明涉及使用IL-6拮抗剂例如Ab1抗体或对IL-6具有结合特异性的抗体片段来预防或治疗疾病或改善有需要的患者的生存能力或生活质量的治疗方法。 在优选实施方案中，这些患者将包括显示（或有发展风险）升高的血清C-反应蛋白水平，降低的血清白蛋白水平，升高的D-二聚体或其他凝血级联相关蛋白，恶病质，发热，虚弱和 /或治疗前的疲劳。 主题疗法还可以包括施用其它活性物质，例如化学治疗剂，抗凝血剂，他汀类药物等。

公开(公告)号：US09775921B2

公开(公告)日：2017-10-03

申请号：US13511865

申请日：2010-11-24

申请人： Leon F. Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Anderson ,  Benjamin H. Dutzar ,  John A. Latham ,  Brian R. Kovacevich ,  Jeffrey T. L. Smith ,  Mark Litton ,  Randall Schatzman

发明人： Leon F. Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Anderson ,  Benjamin H. Dutzar ,  John A. Latham ,  Brian R. Kovacevich ,  Jeffrey T. L. Smith ,  Mark Litton ,  Randall Schatzman

IPC分类号： A61K39/395 ,  A61K51/10 ,  A61K49/00 ,  C07K16/24 ,  G01N33/68 ,  A61K39/00

CPC分类号： A61K51/1033 ,  A61K49/0004 ,  A61K49/0058 ,  A61K2039/505 ,  C07K16/248 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6863 ,  Y02A50/412 ,  Y02A50/58

摘要： The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. Additional preferred embodiments of the subject invention relate to therapeutic compositions and methods treating or preventing rheumatoid arthritis, especially subcutaneous and intravenous formulations and dosage regimens using IL-6 antagonists according to the invention, as well as methods for preventing or treating GVHD or leukemia relapse in subjects receiving transplanted cells, tissue or organs, use thereof in the treatment or prevention of mucositis, and use thereof to potentiate the cytotoxic, apoptotic, and anti-metastatic or anti-invasive effects of chemotherapeutics and radiation on cancers, especially cancers that have developed a resistance to radiation or chemotherapy, such as an EGFR inhibitor.

公开(公告)号：US20090104187A1

公开(公告)日：2009-04-23

申请号：US12124723

申请日：2008-05-21

申请人： Brian R. Kovacevich ,  John Latham

发明人： Brian R. Kovacevich ,  John Latham

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/08 ,  C07K16/12 ,  C07K16/24 ,  C07K16/22 ,  C12N15/13 ,  A61P29/00 ,  A61P35/00 ,  C12N15/63 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C07H21/04

CPC分类号： C07K16/241 ,  C07K16/248 ,  C07K16/461 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/567

摘要： The present invention is directed to novel and improved methods for humanizing rabbit heavy and light variable regions. The resulting humanized rabbit heavy and light chains and antibodies and antibody fragments containing are well suited for use in immunotherapy and immunodiagnosis as they retain the antigen binding affinity of the parent antibody and based on their very high level of sequence identity to human antibody sequences should be essentially non-immunogenic in humans. The invention exemplifies the protocol for the manufacture of therapeutic humanized anti-human TNF-alpha and anti-human IL-6 antibodies.

摘要翻译： 本发明涉及用于人源化兔重和轻可变区的新颖和改进的方法。 所得到的人源化兔重和轻链和抗体和抗体片段非常适合用于免疫治疗和免疫诊断，因为它们保留亲本抗体的抗原结合亲和力，并且基于与人抗体序列的非常高水平的序列同一性应该是 在人体中基本上是非免疫原性的。 本发明例证了用于制备治疗性人源化抗人TNF-α和抗人IL-6抗体的方案。

公开(公告)号：US5578478A

公开(公告)日：1996-11-26

申请号：US421754

申请日：1995-04-14

申请人： John Rambosek ,  Chris S. Piddington ,  Brian R. Kovacevich ,  Kevin D. Young ,  Sylvia A. Denome

发明人： John Rambosek ,  Chris S. Piddington ,  Brian R. Kovacevich ,  Kevin D. Young ,  Sylvia A. Denome

IPC分类号： C12N15/09 ,  C07K14/195 ,  C10G32/00 ,  C12N1/21 ,  C12N9/00 ,  C12N15/00 ,  C12N15/52 ,  C12Q1/68 ,  C12R1/01 ,  C12R1/19 ,  C12N9/14 ,  C07H19/00 ,  C12N1/20 ,  C12P21/06

CPC分类号： C12R1/01 ,  C10G32/00 ,  C12N15/52

摘要： This invention relates to a recombinant DNA molecule containing a gene or genes which encode a biocatalyst capable of desulfurizing a fossil fuel which contains organic sulfur molecules. For example, the present invention encompasses a recombinant DNA molecule containing a gene or genes of a strain of Rhodococcus rhodochrous.

摘要翻译： 本发明涉及含有编码能够对含有有机硫分子的化石燃料脱硫的生物催化剂的基因或基因的重组DNA分子。 例如，本发明包括含有玫瑰色红球菌菌株的基因或基因的重组DNA分子。

公开(公告)号：US20090238825A1

公开(公告)日：2009-09-24

申请号：US12399156

申请日：2009-03-06

申请人： Brian R. Kovacevich ,  John Latham

发明人： Brian R. Kovacevich ,  John Latham

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/08 ,  C07K16/12 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  C40B30/00

CPC分类号： C07K16/241 ,  C07K16/248 ,  C07K16/461 ,  C07K2317/24 ,  C07K2317/73

摘要： The present invention is directed to novel and improved methods for humanizing rabbit heavy and light variable regions. The resulting humanized rabbit heavy and light chains and antibodies and antibody fragments containing are well suited for use in immunotherapy and immunodiagnosis as they retain the antigen binding affinity of the parent antibody and based on their very high level of sequence identity to human antibody sequences should be essentially non-immunogenic in humans. The invention exemplifies the protocol for the manufacture of therapeutic humanized anti-human TNF-alpha and anti-human IL-6 antibodies.

摘要翻译： 本发明涉及用于人源化兔重和轻可变区的新颖和改进的方法。 所得到的人源化兔重和轻链和抗体和抗体片段非常适合用于免疫治疗和免疫诊断，因为它们保留亲本抗体的抗原结合亲和力，并且基于与人抗体序列的非常高水平的序列同一性应该是 在人体中基本上是非免疫原性的。 本发明例证了用于制备治疗性人源化抗人TNF-α和抗人IL-6抗体的方案。

公开(公告)号：US5879914A

公开(公告)日：1999-03-09

申请号：US421791

申请日：1995-04-14

申请人： John Rambosek ,  Chris S. Piddington ,  Brian R. Kovacevich ,  Kevin D. Young ,  Sylvia A. Denome

发明人： John Rambosek ,  Chris S. Piddington ,  Brian R. Kovacevich ,  Kevin D. Young ,  Sylvia A. Denome

IPC分类号： C12N15/09 ,  C07K14/195 ,  C10G32/00 ,  C12N1/21 ,  C12N9/00 ,  C12N15/00 ,  C12N15/52 ,  C12Q1/68 ,  C12R1/01 ,  C12R1/19 ,  C12P11/00 ,  C07H21/04 ,  C12N9/88

CPC分类号： C12R1/01 ,  C10G32/00 ,  C12N15/52

摘要： This invention relates to recombinant DNA molecule containing a gene or genes which encode a biocatalyst capable of desulfurizing a fossil fuel which contains organic sulfur molecules. For example, the present invention encompasses a recombinant DNA molecule containing a gene or genes of a strain of Rhodococcus rhodochrous.

摘要翻译： 本发明涉及含有编码可以含有有机硫分子的化石燃料脱硫的生物催化剂的基因或基因的重组DNA分子。 例如，本发明包括含有玫瑰色红球菌菌株的基因或基因的重组DNA分子。