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公开(公告)号：US20130336975A1
公开(公告)日：2013-12-19
申请号：US13833338
申请日：2013-03-15
申请人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/94
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
摘要翻译： 本发明涉及对NGF具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还考虑了抗NGF抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗NGF抗体及其结合片段的方法。 本发明的实施方案还涉及抗NGF抗体及其结合片段用于诊断，评估和治疗与NGF相关的疾病和病症的用途。
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公开(公告)号：US09783602B2
公开(公告)日：2017-10-10
申请号：US13309295
申请日：2011-12-01
申请人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号： A61K39/395 , C07K16/22 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
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公开(公告)号：US09499611B2
公开(公告)日：2016-11-22
申请号：US13309295
申请日：2011-12-01
申请人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号： A61K39/395 , C07K16/22 , C07K16/28 , A61K45/06 , A61K39/00
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
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公开(公告)号：US20130302399A1
公开(公告)日：2013-11-14
申请号：US13795674
申请日：2013-03-12
申请人： Andrew Lawrence Feldhaus , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Ethan Wayne Ojala , Brian Robert Kovacevich , Katie Olson , Pei Fan , Jens Billgren , Erica Ann Stewart , Corinne C. Akatsuka , Patricia Dianne McNeill , Danielle Marie Mitchell , Dan Scott Allison , John A. Latham
发明人： Andrew Lawrence Feldhaus , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Ethan Wayne Ojala , Brian Robert Kovacevich , Katie Olson , Pei Fan , Jens Billgren , Erica Ann Stewart , Corinne C. Akatsuka , Patricia Dianne McNeill , Danielle Marie Mitchell , Dan Scott Allison , John A. Latham
IPC分类号： C07K16/40 , A61K45/06 , A61K39/395
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96433
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.
摘要翻译： 本发明涉及对PCSK9具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还考虑了抗PCSK9抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗PCSK9抗体及其结合片段的方法。 本发明的实施方案还涉及抗PCSK9抗体及其结合片段用于诊断，评估和治疗与PCSK9相关的疾病和病症的用途。
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公开(公告)号：US11214610B2
公开(公告)日：2022-01-04
申请号：US13466795
申请日：2012-05-08
申请人： Patricia Dianne McNeill , Leon F. Garcia-Martinez , Nicole Janson , Gary Lesnicki , Pei Qi , John A. Latham
发明人： Patricia Dianne McNeill , Leon F. Garcia-Martinez , Nicole Janson , Gary Lesnicki , Pei Qi , John A. Latham
摘要： Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.
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6.发明申请HIGH-PURITY PRODUCTION OF MULTI-SUBUNIT PROTEINS SUCH AS ANTIBODIES IN TRANSFORMED MICROBES SUCH AS PICHIA PASTORIS 审中-公开多亚型蛋白质的高纯度生产如转化微生物中的抗体如PICHIA PASTORIS公开(公告)号：US20120277408A1
公开(公告)日：2012-11-01
申请号：US13466795
申请日：2012-05-08
申请人： Patricia Dianne McNeill , Leon F. Garcia-Martinez , Nicole Janson , Gary Lesnicki , Pei Qi , John A. Latham
发明人： Patricia Dianne McNeill , Leon F. Garcia-Martinez , Nicole Janson , Gary Lesnicki , Pei Qi , John A. Latham
CPC分类号： C07K16/00 , C07K2317/14 , C12P21/00
摘要： Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.
摘要翻译： 公开了在转化细胞中产生异源多亚基蛋白的方法。 特别地，本公开提供了产生多亚单位蛋白质的改进方法，所述多亚单位蛋白质包括抗体和其它多亚基蛋白质，其可以分泌或不分泌，具有更高的产量和减少不期望的副产物的产生。 在示例性实施方案中，转化的细胞是酵母，例如甲基营养酵母，例如巴斯德毕赤酵母。
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公开(公告)号：US10150968B2
公开(公告)日：2018-12-11
申请号：US13589584
申请日：2012-08-20
申请人： Danielle Marie Mitchell , Leon F. Garcia-Martinez , Patricia Dianne McNeill , Ethan Wayne Ojala , Mehmet Inan , John Latham
发明人： Danielle Marie Mitchell , Leon F. Garcia-Martinez , Patricia Dianne McNeill , Ethan Wayne Ojala , Mehmet Inan , John Latham
摘要： Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.
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8.发明申请MULTI-COPY STRATEGY FOR HIGH-TITER AND HIGH-PURITY PRODUCTION OF MULTI-SUBUNIT PROTEINS SUCH AS ANTIBODIES IN TRANSFORMED MICROBES SUCH AS PICHIA PASTORIS 审中-公开用于高倍数和高纯度生产多亚种蛋白质的多重策略如转化微生物中的抗体如PICHIA PASTORIS公开(公告)号：US20130045888A1
公开(公告)日：2013-02-21
申请号：US13589584
申请日：2012-08-20
申请人： Danielle Marie Mitchell , Leon F. Garcia-Martinez , Patricia Dianne McNeill , Ethan Wayne Ojala , Mehmet Inan , John Latham
发明人： Danielle Marie Mitchell , Leon F. Garcia-Martinez , Patricia Dianne McNeill , Ethan Wayne Ojala , Mehmet Inan , John Latham
CPC分类号： C12N15/815 , C07K16/00 , C07K2317/14 , C07K2319/036 , C07K2319/50 , C12N1/16 , C12P21/005 , C12P21/02
摘要： Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.
摘要翻译： 公开了在转化细胞中产生异源多亚基蛋白的方法。 特别地，本公开提供了产生多亚单位蛋白质的改进方法，所述多亚单位蛋白质包括抗体和其它多亚基蛋白质，其可以分泌或不分泌，具有更高的产量和减少不期望的副产物的产生。 在示例性实施方案中，转化的细胞是酵母，例如甲基营养酵母，例如巴斯德毕赤酵母。
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9.发明授权公开(公告)号：US08920776B2
公开(公告)日：2014-12-30
申请号：US10501841
申请日：2003-01-22
申请人： Alexander Gaiger , Paul A. Algate , Jane Mannion , Jonathan David Clapper , Aijun Wang , Nadia Ordonez , Lauren Carter , Patricia Dianne McNeill
发明人： Alexander Gaiger , Paul A. Algate , Jane Mannion , Jonathan David Clapper , Aijun Wang , Nadia Ordonez , Lauren Carter , Patricia Dianne McNeill
IPC分类号： A61K51/10 , A61K39/395 , C07K16/30 , G01N33/574 , A61K39/00
CPC分类号： C07K16/3061 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/6851 , A61K51/1018 , A61K2039/505 , C07K14/47 , C07K14/70535 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57426
摘要： Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of variety of leukemias and lymphomas.
摘要翻译： 公开了用于血液恶性肿瘤，特别是B细胞白血病，淋巴瘤和多发性骨髓瘤的检测，诊断，预后和治疗的方法和组合物。 公开了用于在动物中引发对特定恶性肿瘤相关抗原性多肽及其抗原性多肽片段的免疫和T细胞应答的组合物，方法和试剂盒。 还公开了用于鉴定含有一种或多种血液恶性肿瘤相关组合物的细胞和生物样品的组合物和方法，以及用于检测和诊断这些疾病和受影响的细胞类型的方法。 还公开了诊断和治疗试剂盒，以及用于诊断，治疗和/或预防多种白血病和淋巴瘤的方法。
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10.发明授权Compositions and methods for the detection, diagnosis and therapy of hematological malignancies 失效用于检测，诊断和治疗血液恶性肿瘤的组合物和方法公开(公告)号：US08071732B2
公开(公告)日：2011-12-06
申请号：US11542681
申请日：2006-10-02
申请人： Alexander Gaiger , Paul A. Algate , Jane Mannion , Jonathan D. Clapper , Aijun Wang , Nadia Ordonez , Lauren Carter , Patricia Dianne McNeill
发明人： Alexander Gaiger , Paul A. Algate , Jane Mannion , Jonathan D. Clapper , Aijun Wang , Nadia Ordonez , Lauren Carter , Patricia Dianne McNeill
IPC分类号： C12P21/08
CPC分类号： C07K16/3061 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/6851 , A61K51/1018 , A61K2039/505 , C07K14/47 , C07K14/70535 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57426
摘要： Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
摘要翻译： 公开了用于血液恶性肿瘤，特别是B细胞白血病，淋巴瘤和多发性骨髓瘤的检测，诊断，预后和治疗的方法和组合物。 公开了用于在动物中引发对特定恶性肿瘤相关抗原性多肽及其抗原性多肽片段的免疫和T细胞应答的组合物，方法和试剂盒。 还公开了用于鉴定含有一种或多种血液恶性肿瘤相关组合物的细胞和生物样品的组合物和方法，以及用于检测和诊断这些疾病和受影响的细胞类型的方法。 还公开了诊断和治疗试剂盒，以及用于诊断，治疗和/或预防各种白血病和淋巴瘤的方法。
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