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公开(公告)号：US20100240618A1
公开(公告)日：2010-09-23
申请号：US12555650
申请日：2009-09-08
申请人： Andrew M.K. Pennell , James B. Aggen , J.J. Kim Wright , Subhabrata Sen , Brian E. McMaster , Daniel Joseph Dairaghi , Wei Chen , Penglie Zhang
发明人： Andrew M.K. Pennell , James B. Aggen , J.J. Kim Wright , Subhabrata Sen , Brian E. McMaster , Daniel Joseph Dairaghi , Wei Chen , Penglie Zhang
IPC分类号： A61K31/655 , A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/4709 , C07C245/04 , C07D413/14 , C07D473/00 , C07D403/14 , C07D401/14 , C07D403/12 , A61P37/06 , A61P29/00
CPC分类号： C07D403/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/38 , C07D231/56 , C07D233/61 , C07D235/06 , C07D235/16 , C07D249/08 , C07D249/14 , C07D257/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D473/34 , A61K2300/00
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US08324216B2
公开(公告)日：2012-12-04
申请号：US12555650
申请日：2009-09-08
申请人： Andrew M. K. Pennell , James B. Aggen , J. J. Kim Wright , Subhabrata Sen , Brian E. McMaster , Daniel Joseph Dairaghi , Wei Chen , Penglie Zhang
发明人： Andrew M. K. Pennell , James B. Aggen , J. J. Kim Wright , Subhabrata Sen , Brian E. McMaster , Daniel Joseph Dairaghi , Wei Chen , Penglie Zhang
IPC分类号： A61K31/496 , C07D233/61 , C07D249/14 , C07D257/04
CPC分类号： C07D403/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/38 , C07D231/56 , C07D233/61 , C07D235/06 , C07D235/16 , C07D249/08 , C07D249/14 , C07D257/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D473/34 , A61K2300/00
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US07589199B2
公开(公告)日：2009-09-15
申请号：US11008774
申请日：2004-12-08
申请人： Andrew M. K. Pennell , James B. Aggen , J. J. Kim Wright , Subhabrata Sen , Brian E. McMaster , Daniel Joseph Dairaghi , Wei Chen , Penglie Zhang
发明人： Andrew M. K. Pennell , James B. Aggen , J. J. Kim Wright , Subhabrata Sen , Brian E. McMaster , Daniel Joseph Dairaghi , Wei Chen , Penglie Zhang
IPC分类号： A61K31/496 , C07D401/14 , C07D403/14
CPC分类号： C07D403/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/38 , C07D231/56 , C07D233/61 , C07D235/06 , C07D235/16 , C07D249/08 , C07D249/14 , C07D257/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D473/34 , A61K2300/00
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US07435830B2
公开(公告)日：2008-10-14
申请号：US11071880
申请日：2005-03-02
申请人： Andrew M. K. Pennell , James B. Aggen , J. J. Kim Wright , Subhabrata Sen , Wei Chen , Daniel Joseph Dairaghi , Penglie Zhang
发明人： Andrew M. K. Pennell , James B. Aggen , J. J. Kim Wright , Subhabrata Sen , Wei Chen , Daniel Joseph Dairaghi , Penglie Zhang
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D471/10 , C07D487/08
摘要： Compounds are provided that act as potent modulators of one or more of the CCR1, CCR2 and CCR3 receptors. The compounds are generally fused-, spiro- or bridged-nitrogen heterocycles having an aryl and heteroaryl component and are useful in pharmaceutical compositions, methods for the treatment of CCR1-, CCR2- and/or CCR3-mediated diseases, and as controls in assays for the identification of competitive receptor antagonists for the above chemokine receptors.
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公开(公告)号：US07435831B2
公开(公告)日：2008-10-14
申请号：US11219637
申请日：2005-09-01
申请人： Wei Chen , Penglie Zhang , James B. Aggen , Daniel Joseph Dairaghi , Andrew M. K. Pennell , Subhabrata Sen , J. J. Kim Wright
发明人： Wei Chen , Penglie Zhang , James B. Aggen , Daniel Joseph Dairaghi , Andrew M. K. Pennell , Subhabrata Sen , J. J. Kim Wright
IPC分类号： C07D487/04
CPC分类号： C07D471/10 , C07D487/04 , C07D487/08
摘要： Compounds are provided that act as potent modulators of one or more of the CCR1, CCR2 and CCR3 receptors. The compounds are generally fused-, spiro- or bridged-nitrogen heterocycles having an aryl and heteroaryl component and are useful in pharmaceutical compositions, methods for the treatment of CCR1-, CCR2- and/or CCR3-mediated diseases, and as controls in assays for the identification of competitive receptor antagonists for the above chemokine receptors.
摘要翻译： 提供了作为CCR1，CCR2和CCR3受体中一种或多种的有效调节剂的化合物。 化合物通常是具有芳基和杂芳基组分的稠合，螺或氮杂环，并且可用于药物组合物，用于治疗CCR1，CCR2和/或CCR3介导的疾病的方法，以及用于测定中的对照 用于鉴定上述趋化因子受体的竞争性受体拮抗剂。
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公开(公告)号：US20090252779A1
公开(公告)日：2009-10-08
申请号：US12418516
申请日：2009-04-03
申请人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu
发明人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu
IPC分类号： A61F2/04 , C07D471/04 , A61K31/497 , A61K31/5377
CPC分类号： C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US20130338157A1
公开(公告)日：2013-12-19
申请号：US13774938
申请日：2013-02-22
申请人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
发明人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US20110098308A1
公开(公告)日：2011-04-28
申请号：US12829312
申请日：2010-07-01
申请人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
发明人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
IPC分类号： A61K31/497 , C07D471/04 , A61P19/02 , A61P25/00 , A61P17/00 , A61P1/00 , A61P37/08 , A61P25/16 , A61P25/28
CPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US20060106218A1
公开(公告)日：2006-05-18
申请号：US11008774
申请日：2004-12-08
申请人： Andrew Pennell , James Aggen , J.J. Wright , Subhabrata Sen , Brian McMaster , Daniel Dairaghi , Wei Chen , Penglie Zhang
发明人： Andrew Pennell , James Aggen , J.J. Wright , Subhabrata Sen , Brian McMaster , Daniel Dairaghi , Wei Chen , Penglie Zhang
IPC分类号： C07D403/02
CPC分类号： C07D403/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/38 , C07D231/56 , C07D233/61 , C07D235/06 , C07D235/16 , C07D249/08 , C07D249/14 , C07D257/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D473/34 , A61K2300/00
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US20060074121A1
公开(公告)日：2006-04-06
申请号：US11219637
申请日：2005-09-01
申请人： Wei Chen , Penglie Zhang , James Aggen , Daniel Dairaghi , Andrew Pennell , Subhabrata Sen , J.J. Wright
发明人： Wei Chen , Penglie Zhang , James Aggen , Daniel Dairaghi , Andrew Pennell , Subhabrata Sen , J.J. Wright
IPC分类号： A61K31/4162 , C07D487/02
CPC分类号： C07D471/10 , C07D487/04 , C07D487/08
摘要： Compounds are provided that act as potent modulators of one or more of the CCR1, CCR2 and CCR3 receptors. The compounds are generally fused-, spiro- or bridged-nitrogen heterocycles having an aryl and heteroaryl component and are useful in pharmaceutical compositions, methods for the treatment of CCR1-, CCR2- and/or CCR3-mediated diseases, and as controls in assays for the identification of competitive receptor antagonists for the above chemokine receptors.
摘要翻译： 提供了作为CCR1，CCR2和CCR3受体中一种或多种的有效调节剂的化合物。 化合物通常是具有芳基和杂芳基组分的稠合，螺或氮杂环，并且可用于药物组合物，用于治疗CCR1，CCR2和/或CCR3介导的疾病的方法，以及用于测定中的对照 用于鉴定上述趋化因子受体的竞争性受体拮抗剂。
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