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公开(公告)号：US08283329B2
公开(公告)日：2012-10-09
申请号：US11905368
申请日：2007-09-28
申请人： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
摘要翻译： 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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公开(公告)号：US08580754B2
公开(公告)日：2013-11-12
申请号：US11905449
申请日：2007-10-01
申请人： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
IPC分类号： C12N15/113 , C07H21/04
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US07560438B2
公开(公告)日：2009-07-14
申请号：US10283190
申请日：2002-10-30
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US06506559B1
公开(公告)日：2003-01-14
申请号：US09215257
申请日：1998-12-18
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
IPC分类号： C12Q168
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US20080248576A1
公开(公告)日：2008-10-09
申请号：US11905368
申请日：2007-09-28
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
摘要翻译： 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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公开(公告)号：US20130029425A1
公开(公告)日：2013-01-31
申请号：US13557995
申请日：2012-07-25
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
IPC分类号： C12N15/82
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
摘要翻译： 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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公开(公告)号：US07622633B2
公开(公告)日：2009-11-24
申请号：US10283267
申请日：2002-10-30
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US07538095B2
公开(公告)日：2009-05-26
申请号：US10282996
申请日：2002-10-30
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
摘要翻译： 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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公开(公告)号：US06576218B1
公开(公告)日：2003-06-10
申请号：US09982465
申请日：2001-10-18
申请人： Peter C. Roberts , Samuel E. Driver
发明人： Peter C. Roberts , Samuel E. Driver
IPC分类号： A61K4800
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/00 , C12N15/1136 , C12N15/1138 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3521
摘要： This invention provides synthetic oligonucleotides that are useful for transplacental delivery, the oligonucleotides being DNA or RNA or both, preferably between 12-35 nucleotides in length, having a stabilized and charged backbone and at least one chemically modified base or sugar moiety, wherein the modified base or sugar moiety facilitates transplacental delivery.
摘要翻译： 本发明提供可用于跨胎盘递送的合成寡核苷酸，寡核苷酸是DNA或RNA或两者，优选长度为12-35个核苷酸，具有稳定和带电的主链和至少一个化学修饰的碱基或糖部分，其中经修饰的 碱或糖部分促进跨胎盘递送。
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公开(公告)号：US06306831B1
公开(公告)日：2001-10-23
申请号：US09150999
申请日：1998-09-10
申请人： Peter C. Roberts , Samuel E. Driver
发明人： Peter C. Roberts , Samuel E. Driver
IPC分类号： A61K4800
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/00 , C12N15/1136 , C12N15/1138 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3521
摘要： This invention provides synthetic oligonucleotides that are useful for transplacental delivery, the oligonucleotides being DNA or RNA or both, preferably between 12-35 nucleotides in length, having a stabilized and charged backbone and at least one chemically modified base or sugar moiety, wherein the modified base or sugar moiety facilitates transplacental delivery.
摘要翻译： 本发明提供可用于跨胎盘递送的合成寡核苷酸，寡核苷酸是DNA或RNA或两者，优选长度为12-35个核苷酸，具有稳定和带电的主链和至少一个化学修饰的碱基或糖部分，其中经修饰的 碱或糖部分促进跨胎盘递送。
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