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11 条记录 (耗时 0.022 秒)

    Electromagnetically controlled heart valve
    1.
    发明授权
    Electromagnetically controlled heart valve 失效
    电磁控制心脏瓣膜

    公开(公告)号：US5135538A

    公开(公告)日：1992-08-04

    申请号：US709782

    申请日：1991-06-03

    申请人： Andrzej M. Pawlak ,  David B. Young

    发明人： Andrzej M. Pawlak ,  David B. Young

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2409 ,  A61F2/2406 ,  Y10T137/7838 ,  Y10T137/7898

    摘要： A unidirectional flow heart valve includes a passageway having an inlet side and an outlet side. A disk occluder is disposed within the passageway. The disk occluder has a closed position wherein the disk occluder occludes fluid flow through the passageway and an open position wherein the disk occluder permits fluid flow through the passageway. A fulcrum causes the disk occluder to pivot off center between the open and closed positions. An electromagnetic control mechanism forces the disk occluder to remain closed when energized until a predetermined net pressure is reached against the disk occluder. When the electromagnetic control mechanism is either selectively deenergized or the force on the occluder disk is greater than the holding force of the electromagnetic control mechanism, the disk occluder is released from the closed position to pivot on the fulcrum in response to fluid pressure.

    摘要翻译： 单向流心脏瓣膜包括具有入口侧和出口侧的通道。 盘片封堵器设置在通道内。 盘封闭器具有闭合位置，其中盘封闭器封闭通过通道的流体流动，以及打开位置，其中盘封闭器允许流体流过通道。 支点导致盘闭塞器在打开位置和关闭位置之间从中心枢转。 当通电时，电磁控制机构迫使盘封闭器保持关闭，直到达到预定的净压力而抵靠盘封闭器。 当电磁控制机构被选择性地断电或阻塞盘上的力大于电磁控制机构的保持力时，盘封闭器从关闭位置释放，以响应于流体压力在支点上枢转。

    Drive system for artificial hearts and left-ventricular assist devices
    2.
    发明授权
    Drive system for artificial hearts and left-ventricular assist devices 失效
    人造心脏和左心室辅助装置的驱动系统

    公开(公告)号：US5089017A

    公开(公告)日：1992-02-18

    申请号：US298119

    申请日：1989-01-17

    申请人： David B. Young ,  Andrzej M. Pawlak

    发明人： David B. Young ,  Andrzej M. Pawlak

    IPC分类号： A61F2/02 ,  A61M1/10

    CPC分类号： A61M1/106 ,  A61F2250/0001

    摘要： A drive system for artificial hearts and left-ventricular assist devices. The drive system includes one or more implantable pumps driven by external electromagnets. Each pump preferably includes an armature made of a permanent magnet material having a magnetic energy product of at least about 30.times.10.sup.6 Gauss Oersted, and coercivity of at least about 10 kOe.In one embodiment of the invention, a pair of pumps are provided, with each being coupled to a respective ventricle of an artificial heart. In a second embodiment, a pair of pumps is connected to a single left-ventricular assist device.Each pump is mounted to the pelvic bone in the vicinity of the iliac crest. Fluid communication between the pump and its associated ventricle or left-ventricular assist device is provided by a length of flexible tubing extending subcutaneously up from the pump. Means are provided to enable periodic reversal of internal system leakage, and to enable replenishment of fluid lost from the system.Each electromagnet may be operated and powered by a plurality of rechargeable batteries and a PWM-type controller with a DC/DC converter. The electromagnets, batteries, and controller may be supported on a belt or girdle to provide a portable system, or alternatively may be mounted in a stationary support.

    摘要翻译： 人造心脏和左心室辅助装置的驱动系统。 驱动系统包括由外部电磁体驱动的一个或多个可植入泵。 每个泵优选地包括由永磁材料制成的电枢，其具有至少约30×10 6高斯奥斯特的磁能积和至少约10kOe的矫顽力。 在本发明的一个实施例中，提供了一对泵，每个泵联接到人造心脏的相应心室。 在第二实施例中，一对泵连接到单个左心室辅助装置。 每个泵都安装在髂骨附近的骨盆骨。 泵与其相关心室或左心室辅助装置之间的流体连通通过从泵皮下向上延伸的一段柔性管提供。 提供装置以使得能够周期性地反转内部系统泄漏，并且能够补充从系统丢失的流体。 每个电磁体可以由多个可充电电池和具有DC / DC转换器的PWM型控制器操作和供电。 电磁体，电池和控制器可以被支撑在带或腰带上以提供便携式系统，或者可以安装在固定支撑件中。

    Mitogen-activated protein kinase p38-2 and methods of use therefor
    5.
    发明授权
    Mitogen-activated protein kinase p38-2 and methods of use therefor 失效
    丝裂原活化蛋白激酶p38-2及其使用方法

    公开(公告)号：US07202049B2

    公开(公告)日：2007-04-10

    申请号：US10197315

    申请日：2002-07-16

    申请人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

    发明人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

    IPC分类号： C12Q1/00 ,  C12Q1/48 ,  C12N9/00 ,  C12N9/12 ,  C07H21/04

    CPC分类号： C12N9/1205 ,  A61K38/00

    摘要： Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

    摘要翻译： 提供组合物和方法用于治疗与丝裂原活化蛋白激酶级联相关的疾病。 特别地，提供了刺激磷酸化和激活底物如ATF2的丝裂原活化蛋白激酶p38-2及其多肽变体。 多肽可用于例如鉴定通过p38-2激酶级联抑制或激活信号转导的抗体和其它试剂。 此类多肽和试剂也可用于治疗与丝裂原活化蛋白激酶级联相关的疾病。

    Mitogen-activated protein kinase p38-2 and methods of use therefor
    6.
    发明授权
    Mitogen-activated protein kinase p38-2 and methods of use therefor 失效
    丝裂原活化蛋白激酶p38-2及其使用方法

    公开(公告)号：US06677130B1

    公开(公告)日：2004-01-13

    申请号：US09724768

    申请日：2000-11-28

    申请人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

    发明人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

    IPC分类号： A01N100

    CPC分类号： C12N9/1205 ,  A61K38/00

    摘要： Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

    摘要翻译： 提供组合物和方法用于治疗与丝裂原活化蛋白激酶级联相关的疾病。 特别地，提供了刺激磷酸化和激活底物如ATF2的丝裂原活化蛋白激酶p38-2及其多肽变体。 多肽可用于例如鉴定通过p38-2激酶级联抑制或激活信号转导的抗体和其它试剂。 此类多肽和试剂也可用于治疗与丝裂原活化蛋白激酶级联相关的疾病。

    Mitogen-activated protein kinase P38-2 and methods of use therefor
    8.
    发明授权
    Mitogen-activated protein kinase P38-2 and methods of use therefor 失效
    丝裂原活化蛋白激酶P38-2及其使用方法

    公开(公告)号：US06444455B1

    公开(公告)日：2002-09-03

    申请号：US09295029

    申请日：1999-04-20

    申请人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

    发明人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

    IPC分类号： C12N900

    CPC分类号： C12N9/1205 ,  A61K38/00

    摘要： Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

    摘要翻译： 提供组合物和方法用于治疗与丝裂原活化蛋白激酶级联相关的疾病。 特别地，提供了刺激磷酸化和激活底物如ATF2的丝裂原活化蛋白激酶p38-2及其多肽变体。 多肽可用于例如鉴定通过p38-2激酶级联抑制或激活信号转导的抗体和其它试剂。 此类多肽和试剂也可用于治疗与丝裂原活化蛋白激酶级联相关的疾病。