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公开(公告)号：US20080039464A1
公开(公告)日：2008-02-14
申请号：US11781336
申请日：2007-07-23
申请人： Angela BERRY , Pier CIRILLO , Eugene HICKEY , Doris RIETHER , David Thomson , Monika ERMANN , James JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher PALMER , Nigel BLUMIRE
发明人： Angela BERRY , Pier CIRILLO , Eugene HICKEY , Doris RIETHER , David Thomson , Monika ERMANN , James JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher PALMER , Nigel BLUMIRE
IPC分类号： A61K31/5377 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/426 , A61P29/00 , C07D215/38 , C07D249/14 , C07D277/38 , C07D417/12 , C07D413/14 , C07D413/12 , C07D285/135 , C07D261/14 , C07D231/38 , A61P37/00 , A61P25/04 , A61K31/433 , A61K31/4439 , A61K31/47
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compound of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20110071127A1
公开(公告)日：2011-03-24
申请号：US12956322
申请日：2010-11-30
申请人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher Francis PALMER , Nigel BLUMIRE
发明人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher Francis PALMER , Nigel BLUMIRE
IPC分类号： A61K31/5377 , C07D261/14 , A61K31/42 , C07D213/70 , A61K31/4402 , C07C321/28 , A61K31/216 , C07D277/36 , A61K31/426 , C07D413/12 , A61K31/4439 , C07D309/08 , A61K31/351 , C07D417/14 , C07D413/14 , A61P29/00 , A61P1/00 , A61P25/28 , A61P35/00 , A61P37/06
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20110130431A1
公开(公告)日：2011-06-02
申请号：US13022866
申请日：2011-02-08
申请人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Renee M. ZINDELL , Nigel BLUMIRE , Chandana CHOWDHURY , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Christopher Francis PALMER , Malcolm TAYLOR
发明人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Renee M. ZINDELL , Nigel BLUMIRE , Chandana CHOWDHURY , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Christopher Francis PALMER , Malcolm TAYLOR
IPC分类号： A61K31/42 , C07D261/14 , C07D277/46 , C07D231/40 , C07D213/75 , C07C233/07 , C07D277/82 , C07D409/04 , C07D217/22 , A61K31/426 , A61K31/415 , A61K31/44 , A61K31/167 , A61K31/428 , A61K31/472 , A61P29/00
CPC分类号： C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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4.发明申请公开(公告)号：US20110312932A1
公开(公告)日：2011-12-22
申请号：US13217480
申请日：2011-08-25
申请人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
发明人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
IPC分类号： A61K31/422 , A61K31/428 , A61K31/42 , A61P25/04 , A61K31/427 , A61K31/433 , A61P29/00 , A61K31/4196 , A61K31/454
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20100081644A1
公开(公告)日：2010-04-01
申请号：US12564132
申请日：2009-09-22
申请人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
发明人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
IPC分类号： A61K31/4196 , C07D413/12 , A61K31/422 , C07D417/12 , A61K31/41 , A61K31/454 , C07D249/14
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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6.发明申请公开(公告)号：US20120010184A1
公开(公告)日：2012-01-12
申请号：US13238054
申请日：2011-09-21
申请人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
发明人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
IPC分类号： A61K31/422 , A61K31/433 , A61K31/428 , A61K31/426 , A61K31/42 , A61K31/4196 , C07D401/12 , C07D285/135 , C07D417/12 , C07D413/12 , C07D249/14 , C07D261/14 , C07D403/12 , A61P29/00 , A61K31/454
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20110071196A1
公开(公告)日：2011-03-24
申请号：US12882328
申请日：2010-09-15
申请人： Alessandra BARTOLOZZI , Doris RIETHER , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Monika ERMANN , Innocent MUSHI , Robert John SCOTT
发明人： Alessandra BARTOLOZZI , Doris RIETHER , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Monika ERMANN , Innocent MUSHI , Robert John SCOTT
IPC分类号： A61K31/4439 , C07D413/14 , A61K31/422 , A61P11/00 , A61P9/10 , A61P1/16 , A61P13/12 , A61P35/00 , A61P37/06 , C07D405/14 , A61K31/4196 , A61K31/427 , C07D417/14 , A61K31/4245
CPC分类号： C07D413/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20120071529A1
公开(公告)日：2012-03-22
申请号：US13037422
申请日：2011-03-01
申请人： Monika ERMANN , Doris RIETHER , Renee M. ZINDELL
发明人： Monika ERMANN , Doris RIETHER , Renee M. ZINDELL
IPC分类号： A61K31/41 , C07D257/06 , A61P11/00 , A61P29/00 , A61P21/00 , A61P37/08 , A61P9/00 , A61P17/00 , A61P13/12 , A61P1/16 , A61P1/00 , A61P27/02 , A61P27/16 , A61P9/10 , A61P1/06 , A61P5/00 , A61P25/00 , A61P7/00 , A61P9/04 , C07D405/12
CPC分类号： C07D405/12 , C07D257/06
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20100076029A1
公开(公告)日：2010-03-25
申请号：US12564133
申请日：2009-09-22
申请人： Alessandra BARTOLOZZI , Eugene Richard HICKEY , Doris RIETHER , Lifen WU , Renee M. ZINDELL , Stephen Peter EAST , Monika ERMANN
发明人： Alessandra BARTOLOZZI , Eugene Richard HICKEY , Doris RIETHER , Lifen WU , Renee M. ZINDELL , Stephen Peter EAST , Monika ERMANN
IPC分类号： A61K31/44 , C07D263/16 , C07D249/14 , C07D401/12 , A61K31/421 , A61K31/4196 , A61P25/00 , A61P17/00 , A61P25/28 , A61P37/06
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
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