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    Injectable liquid copolymers for soft tissue repair and augmentation
    4.
    发明授权
    Injectable liquid copolymers for soft tissue repair and augmentation 失效
    用于软组织修复和增强的注射液体共聚物

    公开(公告)号：US5824333A

    公开(公告)日：1998-10-20

    申请号：US746180

    申请日：1996-11-06

    申请人： Angelo G. Scopelianos ,  Rao S. Bezwada ,  Steven C. Arnold

    发明人： Angelo G. Scopelianos ,  Rao S. Bezwada ,  Steven C. Arnold

    IPC分类号： A61J1/05 ,  A61F2/00 ,  A61L27/00 ,  A61L27/18 ,  C08G63/08 ,  C08G63/64 ,  C08G63/664 ,  A61F2/02 ,  A61F2/08 ,  A61K31/765 ,  C08G63/91

    CPC分类号： C08G63/664 ,  A61K47/34 ,  A61K9/0024 ,  A61L27/18 ,  C08G63/08 ,  C08G63/64 ,  A61F2/0059

    摘要： The present invention provides injectable, bioabsorbable liquid copolymers suitable for use as a soft tissue repair or augmentation material in animals comprising a liquid polymer selected from the group consisting of liquid polymers of a plurality of at least two different first lactone repeating units and liquid polymers of a plurality of first lactone and second lactone repeating units; wherein the first lactone repeating units are selected from the group consisting of .epsilon.-caprolactone repeating units, trimethylene carbonate repeating units, ether lactone repeating units (which for the purpose of this invention shall mean 1,4-dioxepan-2-one and 1,5-dioxepan-2-one) and combinations thereof and the second lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units (which for the purpose of this invention are defined to be L-lactide, D-lactide, or D,L-lactide repeating units), p-dioxanone repeating units and combinations thereof. Additionally, the present invention also discloses methods of using these liquid copolymers for tissue augmentation and repair as well as kits which include prefilled containers to facilitate the use of these materials.

    摘要翻译： 本发明提供了适合用作动物中的软组织修复或增加材料的可注射的生物可吸收液体共聚物，其包含液体聚合物，所述液体聚合物选自多种至少两种不同的第一内酯重复单元的液体聚合物和液体聚合物 多个第一内酯和第二内酯重复单元; 其中所述第一内酯重复单元选自ε-己内酯重复单元，三亚甲基碳酸酯重复单元，醚内酯重复单元（其本发明的目的是指1,4-二氧杂环庚烷-2-酮和1， 5-二氧杂环庚烷-2-酮）及其组合，第二内酯重复单元选自乙交酯重复单元，丙交酯重复单元（其本发明的目的定义为L-丙交酯，D-丙交酯 或D，L-丙交酯重复单元），对二恶烷酮重复单元及其组合。 此外，本发明还公开了使用这些液体共聚物用于组织增加和修复的方法以及包括预装容器以便于使用这些材料的试剂盒。

    Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer
    7.
    发明授权
    Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer 失效
    6,6-二烷基-1,4-二氧杂环庚烷-2-酮及其环状二聚体的可吸收共聚物和共混物

    公开(公告)号：US5703200A

    公开(公告)日：1997-12-30

    申请号：US616799

    申请日：1996-03-15

    申请人： Rao S. Bezwada ,  Steven C. Arnold ,  Constance Ace

    发明人： Rao S. Bezwada ,  Steven C. Arnold ,  Constance Ace

    IPC分类号： A61K47/34 ,  A61L17/00 ,  A61L17/10 ,  A61L17/12 ,  A61L17/14 ,  A61L27/00 ,  A61L27/18 ,  A61L31/06 ,  C08G63/06 ,  C08G63/42 ,  C08G63/66 ,  C08G63/664 ,  C08L67/04 ,  C08L71/02

    CPC分类号： C08G63/664 ,  A61L17/105 ,  A61L17/12 ,  A61L17/145 ,  A61L27/18 ,  A61L31/06

    摘要： This invention provides various copolymers comprising a first repeating unit of the chemical formula: ##STR1## in which R.sub.1 and/or R.sub.2 are alkyl groups and a second repeating units generally having the chemical formula: ##STR2## and combinations of two or more thereof wherein R is a hydrogen atom or a methyl group and the first repeating unit is less than 45 weight percent of the total weight of the copolymer. This invention also relates to use of these copolymers in the fabrication of absorbable surgical devices such as sutures and as coatings for medical devices. Additionally, described are blends and polyoxaesters containing the first repeating unit.

    摘要翻译： 本发明提供了包含化学式为：其中R 1和/或R 2为烷基的第一重复单元和通常具有以下化学式的第二重复单元的各种共聚物：[CHRCO2] [[CH2] 5CO2] [CH2CH2OCH2CO2 [CH 2 CH 2 CH 2 OCH 2] [CH 2 CH 2 CH 2 OCH 2 CO 2] [CH2CH2OCH2CH2CO2]及其两个或多个的组合，其中R是氢原子或甲基，第一重复单元小于共聚物总重量的45重量％。 本发明还涉及这些共聚物在制造可吸收的手术装置如缝合线和用于医疗装置的涂层中的用途。 另外，描述了含有第一重复单元的共混物和聚氧化酯。

    Fuel injector
    10.
    发明授权
    Fuel injector 失效
    喷油器

    公开(公告)号：US06604507B1

    公开(公告)日：2003-08-12

    申请号：US09392814

    申请日：1999-09-09

    申请人： Ning Lei ,  Xilin Yang ,  Steven C. Arnold

    发明人： Ning Lei ,  Xilin Yang ,  Steven C. Arnold

    IPC分类号： F02M3704

    CPC分类号： F02M57/026 ,  F02M45/066 ,  F02M57/025 ,  F02M59/105 ,  F02M61/205

    摘要： A fuel injector includes a spool control valve, a plunger which moves in a fuel pressure chamber between retracted and full stroke positions. The fuel injector may include a spill port for spilling fuel from the fuel pressure chamber, the spill port being open at the start and closed by the translating motion of the plunger to delay the start of injection. The fuel injector chamber may further include a control port which is closed at the start of plunger motion and is opened by the plunger to connect the pressure chamber to a needle back chamber to bias the needle valve closed. The needle back chamber becomes isolated from the pressure chamber by further movement of the plunger and includes a pressure control passage to allow the pressure therein to decay upon control port closure, thereby effecting split injection or rate shaping.

    摘要翻译： 燃料喷射器包括阀芯控制阀，在缩回和全行程位置之间的燃料压力室中移动的柱塞。 燃料喷射器可以包括用于从燃料压力室溢出燃料的溢出口，溢出口在开始时打开并且通过柱塞的平移运动闭合，以延迟注射开始。 燃料喷射器腔室还可以包括控制口，其在柱塞运动开始时被关闭，并且由柱塞打开以将压力室连接到针后室，以将针阀偏置为关闭。 针后室通过柱塞的进一步移动与压力室隔离，并且包括压力控制通道，以允许其中的压力在控制端口关闭时衰减，从而实现分离喷射或速率成形。