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16 条记录 (耗时 0.027 秒)

    Composition
    1.
    发明授权
    Composition 有权
    组成

    公开(公告)号：US07311932B1

    公开(公告)日：2007-12-25

    申请号：US09926586

    申请日：2000-05-22

    申请人： Anna Berggren ,  Marie Louise Johansson ,  Kåre Larsson ,  Anne-Marie Lindberg ,  Jörgen Wiklander

    发明人： Anna Berggren ,  Marie Louise Johansson ,  Kåre Larsson ,  Anne-Marie Lindberg ,  Jörgen Wiklander

    IPC分类号： A23L1/29 ,  A23L2/00

    CPC分类号： A23L2/66 ,  A23L2/39 ,  A23L2/52 ,  A23L29/065 ,  Y10S426/81

    摘要： The invention describes a sports drink, which in addition to conventional additives contains viable lactobacilli having a positive effect on human intestinal mucosa. The sports drink preferably also contains micronutrients and proteins. The invention also refers to a tablet for the preparation of such a sports drink, containing viable freeze-dried lactobacilli in combination with micronutrients. In addition to providing liquid and nutrients replacement, the sports drink also relieves the stress symptoms, which are associated with long physical exercise.

    摘要翻译： 本发明描述了一种运动饮料，除了常规添加剂之外，还含有对人肠粘膜具有积极作用的活的乳酸杆菌。 运动饮料优选还含有微量营养素和蛋白质。 本发明还涉及用于制备这种运动饮料的片剂，其含有与微量营养素组合的活的冷冻干燥的乳酸杆菌。 除了提供液体和营养物质的替代物之外，运动饮料还能减轻与长期运动相关的压力症状。

    1,5-Diaryl-pyrrole-3-carboxamide derivatives and their use as cannabinoid receptor modulators
    9.
    发明申请
    1,5-Diaryl-pyrrole-3-carboxamide derivatives and their use as cannabinoid receptor modulators 审中-公开

    公开(公告)号：US20060122230A1

    公开(公告)日：2006-06-08

    申请号：US10540276

    申请日：2003-12-18

    申请人： Anna Berggren ,  Stig Bosfrom ,  Leifeng Cheng ,  Stig Elebring ,  Peter Greasley ,  Mats Nagard ,  Johan Wilstermann ,  Emma Terricabras

    发明人： Anna Berggren ,  Stig Bosfrom ,  Leifeng Cheng ,  Stig Elebring ,  Peter Greasley ,  Mats Nagard ,  Johan Wilstermann ,  Emma Terricabras

    IPC分类号： A61K31/454 ,  A61K31/4015 ,  A61K31/401

    CPC分类号： C07D401/04 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/454 ,  C07D207/34 ,  C07D401/06

    摘要： The present invention relates to a compound of formula (I) in which R1 and R2 independently represent phenyl, thienyl or pyridyl each of which is optionally substituted by one, two or three groups represented by Z; and R3 is H, a C1-3alkyl group, a C1-3alkoxymethyl group, trifluoromethyl, a hydroxyC1-3alkyl group, an aminoC1-3alkyl group, C1-3alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C1-3alkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula —CONHNRaRb wherein Ra and Rb are as defined for R4 and R5 respectively; X is CO or SO2; Y is absent or represents NH optionally substituted by a C1-3alkyl group; R4 and R5 independently represent: a C1-6alkyl group; an (amino)C1-4alkyl-group in which the amino is optionally substituted by one or more C1-3alkyl groups; an optionally substituted non-aromatic C3-15carbocyclic group; a (C3-12cycloalkyl)C1-3alkyl-group; a group —(CH2)r(phenyl)s; naphthyl; anthracenyl; a saturated 5 to 8 membered heterocyclic group containing one nitrogen and optionally one of the following: oxygen, sulphur or an additional nitrogen wherein the heterocyclic group is optionally substituted; 1-adamantylmethyl; a group —(CH2)t Het where Het represents an aromatic heterocycle optionally substituted; or R4 represents H and R5 is as defined above; or R4 and R5 together with the nitrogen atom to which they are attached represent a saturated 5 to 8 membered heterocyclic group; R6 is H, a C1-3alkyl group, a C1-3alkoxymethyl group, trifluoromethyl, a hydroxyC1-3alkyl group, C1-3alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C1-3alkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula —CONHNRaRb; with provisos; to processes for preparing such compounds, to their use in the treatment of obesity, psychiatric and neurological disorders particularly obesity, to methods for their therapeutic use and to pharmaceutical compositions containing them.

    5 6-diaryl-pyrazine-2-amide derivatives as cb1 antagonists
    10.
    发明申请
    5 6-diaryl-pyrazine-2-amide derivatives as cb1 antagonists 失效

    公开(公告)号：US20050032808A1

    公开(公告)日：2005-02-10

    申请号：US10499054

    申请日：2002-12-18

    申请人： Anna Berggren ,  Stig Jonas Bostrom ,  Stig Elebring ,  Peter Greasley ,  Emma Terricabras ,  Johan Wilstermann

    发明人： Anna Berggren ,  Stig Jonas Bostrom ,  Stig Elebring ,  Peter Greasley ,  Emma Terricabras ,  Johan Wilstermann

    IPC分类号： C07D241/24 ,  A61K20060101 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/497 ,  A61P20060101 ,  A61P3/04 ,  A61P7/00 ,  A61P9/10 ,  A61P15/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P37/00 ,  A61P43/00 ,  C07D20060101

    CPC分类号： C07D241/24

    摘要： The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, prodrugs, solvates and crystalline forms thereof, in which R1 and R2 independently represent: a C1-6alkyl group; an optionally substituted (amino)C1-4alkyl-group; an optionally substituted non-aromatic C3-15carbocyclic group; a (C3-12cycloalkyl)C1-3alkyl-group; a group —(CH2)r(phenyl)s in which r is 0, 1, 2, 3 or 4, s is 1 when r is 0 otherwise s is 1 or 2 and the phenyl groups are optionally independently substituted by Z; naphthyl; anthracenyl; an optionally substituted saturated 5 to 8 membered heterocyclic group containing one nitrogen and optionally one of the following: oxygen, sulphur or an additional nitrogen; 1-adamantylmethyl; a group —(CH2)t Het in which t is 0, 1, 2, 3 or 4, and the alkylene chain is optionally substituted and Het represents an optionally substituted aromatic heterocycle; or R1 represents H and R2 is as defined above; or R1 and R2 together with the nitrogen atom to which they are attached represent a saturated optionally substituted 5 to 8 membered heterocyclic group as defined above; X is CO or SO2; Y is absent or represents NH optionally substitututed by a C1-3alkyl group; R3 and R4 independently represent phenyl, thienyl or pyridyl substituted by Z; Z represents a C1-3alkyl group, a C1-3alkoxy group, hydroxy, halo, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, trifluoromethylsulphonyl, nitro, amino, mono or di C1-3alkylamino, mono or di C1-3alkylamido, C1-3alkylsulphonyl, C1-3alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C1-3alkyl carbamoyl, sulphamoyl and acetyl; and R5 is H, a C1-3alkyl group, a C1-3alkoxymethyl group, trifluoromethyl, a hydroxyC1-3alkyl group, C1-3alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C1-3alkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula —CONHNRaRb; with the provisos; and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.