Process for the preparation of 5-oxohexane nitriles and the compound
2,4-dimethyl-5-oxohexane nitrile
    1.
    发明授权
    Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile 失效
    5-氧代己烷腈和化合物2,4-二甲基-5-氧代己烷腈的制备方法

    公开(公告)号:US5254712A

    公开(公告)日:1993-10-19

    申请号:US902785

    申请日:1992-06-24

    CPC分类号: C07D213/08 C07C255/17

    摘要: The invention relates to a process for the preparation of high yields of 5-oxohexane nitriles with minimum formation of 1 undesired isomer. Such nitriles may be utilized as starting materials for the preparation of pharmaceutical and agrochemical intermediates and as well as final products. The process comprises reacting a methyl ketone and an .alpha.,.beta.-unsaturated nitrile in the presence of a catalytically effective amount of a strong base. One of the products which may be created by the process is 2,4-dimethyl-5-oxohexane nitrile.

    摘要翻译: 本发明涉及一种制备高产量的5-氧代己烷腈的方法,最少形成1种不需要的异构体。 这种腈可以用作制备药物和农药中间体以及最终产品的起始原料。 该方法包括在催化有效量的强碱存在下使甲基酮和α,β-不饱和腈反应。 可以通过该方法产生的产物之一是2,4-二甲基-5-氧代己烷腈。

    2,4-dimethyl-5-oxohexane and a method of use therefor
    2.
    发明授权
    2,4-dimethyl-5-oxohexane and a method of use therefor 失效
    2,4-二甲基-5-氧代己烷及其用途的方法

    公开(公告)号:US5334721A

    公开(公告)日:1994-08-02

    申请号:US98909

    申请日:1993-07-29

    CPC分类号: C07D213/08 C07C255/17

    摘要: The invention relates to a process for the preparation of high yields of 5-oxohexane nitriles with minimum formation of 1 undesired isomer. Such nitriles may be utilized as starting materials for the preparation of pharmaceutical and agrochemical intermediates and as well as final products. The process comprises reacting a methyl ketone and an .alpha.,.beta.-unsaturated nitrile in the presence of a catalytically effective amount of a strong base. One of the products which may be created by the process is 2,4-dimethyl-5-oxohexane nitrile.

    摘要翻译: 本发明涉及一种制备高产量的5-氧代己烷腈的方法,最少形成1种不需要的异构体。 这种腈可以用作制备药物和农药中间体以及最终产品的起始原料。 该方法包括在催化有效量的强碱存在下使甲基酮和α,β-不饱和腈反应。 可以通过该方法产生的产物之一是2,4-二甲基-5-氧代己烷腈。

    Method for preparing an alpha-alkycinnamaldehyde
    4.
    发明授权
    Method for preparing an alpha-alkycinnamaldehyde 失效
    α-烷基肉桂醛的制备方法

    公开(公告)号:US5728892A

    公开(公告)日:1998-03-17

    申请号:US746162

    申请日:1996-11-06

    CPC分类号: C07C45/74

    摘要: The invention relates to a method for preparing an .alpha.-alkylcinnamaldehyde via aldol concensation of a benzaldehyde and an alkanal, with pyrrolidine being employed as a catalyst. The method is suitable, in particular, for preparing .alpha.-hexylcinnamaldehyde by aldol condensation of benzaldehyde and n-octanal, in particular for preparing .alpha.-hexylcinnamaldehyde of olfactory quality, since it was found that, in the method according to the invention, relatively little .alpha.-hexyldecenal, the aldol condensation product of n-octanal, is formed. Preferably, the aldol condensation is carried out without a solvent in the presence of an acid, and the alkanal is metered in over time to a mixture which contains pyrrolidine and benzaldehyde.

    摘要翻译: 本发明涉及通过苯甲醛和链烷醛的醛醇缩合制备α-烷基肉桂醛的方法,其中吡咯烷用作催化剂。 该方法特别适用于通过苯甲醛和正辛醛的醛醇缩合制备α-己基肉桂醛,特别是用于制备嗅觉质量的α-己基肉桂醛,因为发现在根据本发明的方法中,相对较少 形成正辛醛醛醛缩合产物α-正癸醛。 优选地,醛酸缩合在没有溶剂的情况下在酸的存在下进行,并且将烷醛随时间计量加入到含有吡咯烷和苯甲醛的混合物中。

    Process for the preparation N-alkyl-N,O-diacetyl hydroxylamine
    5.
    发明授权
    Process for the preparation N-alkyl-N,O-diacetyl hydroxylamine 失效
    制备N-烷基-N,O-二乙酰羟胺的方法

    公开(公告)号:US5663433A

    公开(公告)日:1997-09-02

    申请号:US668074

    申请日:1996-06-17

    IPC分类号: C07C259/06 C07C231/00

    CPC分类号: C07C259/06

    摘要: Process for the preparation of N-alkyl-N,O-diacetyl hydroxylamine, for instance N-methyl-N,O-diacetyl hydroxylamine, by catalytic reduction of a nitroalkane, for instance nitromethane, in the presence of acetic anhydride. As catalyst preferably a platinum on alumina catalyst is used. The invention provides a simple one-step process for the preparation of N-alkyl-N,O-diacetyl hydroxylamine in a relatively concentrated reaction medium.

    摘要翻译: 在乙酸酐存在下,通过硝基烷烃例如硝基甲烷的催化还原来制备N-烷基-N,O-二乙酰基羟胺,例如N-甲基-N,O-二乙酰基羟胺的方法。 作为催化剂,优选使用氧化铝上的催化剂。 本发明提供了在相对浓缩的反应介质中制备N-烷基-N,O-二乙酰羟胺的简单的一步法。

    Process for the preparation of 3-phenylpropanal
    6.
    发明授权
    Process for the preparation of 3-phenylpropanal 失效
    3-苯基丙醛的制备方法

    公开(公告)号:US5811588A

    公开(公告)日:1998-09-22

    申请号:US834456

    申请日:1997-04-16

    CPC分类号: C07C45/62 C07C51/235

    摘要: Process for the preparation of 3-phenylpropanal in which cinnamaldehyde is hydrogenated with the aid of a Pd-containing catalyst in the presence of a small amount of water. A high yield and a high selectivity are obtained in a commercially attractive process. The reaction mixture obtained can without intermediate further processing be subjected to an oxidation in which the cinnamaldehyde is oxidized to 3-phenylpropionic acid with a high degree of conversion and a high selectivity. The combination of the two process steps constitutes a simple, commercially attractive process for the preparation of 3-phenylpropionic acid using cinnamaldehyde as a starting material. The resulting 3-phenyl-propionic acid product may serve as an intermediate reagent in the synthesis of anti-viral pharmaceuticals, particularly HIV protease inhibitors.

    摘要翻译: 制备3-苯基丙醛的方法,其中肉碱醛在少量水存在的情况下借助含Pd催化剂氢化。 在商业上有吸引力的工艺中获得高产率和高选择性。 所获得的反应混合物不经中间进一步处理,其中肉桂醛以高转化率和高选择性氧化成3-苯基丙酸。 两个工艺步骤的组合构成了使用肉桂醛作为起始原料制备3-苯基丙酸的简单的,商业上有吸引力的方法。 所得3-苯基 - 丙酸产物可用作合成抗病毒药物,特别是HIV蛋白酶抑制剂的中间试剂。

    Method for the preparation of a N-alkoxy-(tetra-or
hexahydro)-phthalimide and method for the preparation of a N-alkoxyamine
    8.
    发明授权
    Method for the preparation of a N-alkoxy-(tetra-or hexahydro)-phthalimide and method for the preparation of a N-alkoxyamine 失效
    制备N-烷氧基 - (四或六氢) - 邻苯二甲酰亚胺的方法及其制备方法

    公开(公告)号:US5824804A

    公开(公告)日:1998-10-20

    申请号:US928126

    申请日:1997-09-12

    IPC分类号: C07D209/48

    CPC分类号: C07D209/48 Y02P20/582

    摘要: Method for the preparation of N-alkoxy-(tetra- or hexahydro)-phthalimide according to formula I ##STR1## R.sub.1 being methyl or ethyl and R.sub.2 and R.sub.3 being each independently of one another hydrogen or alkyl with 1-4 C atoms or R.sub.2 and R.sub.3 together with the carbon atom to which they are bonded forming a ring with 5 or 6 C atoms, wherein the salt of the corresponding N-hydroxy-(tetrahydro- or hexahydro)-phthalimide according to formula II: ##STR2## with R.sub.2 and R.sub.3 as defined above and M being an alkali metal, is brought into contact with R.sub.1 Cl as alkylating agent, wherein R.sub.1 has the aforementioned meaning. The N-alkoxy-(tetra- or hexahydro)-phthalimide can afterwards be converted with the aid of hydroxylamine sulphate into the corresponding alkoxyamine after which the alkoxyamine obtained can be isolated. In this manner a simple and commercially attractive process for the preparation of O-(m)ethylhydroxylamine can be implemented.

    摘要翻译: 用于制备式I的N-烷氧基 - (四或六氢) - 邻苯二甲酰亚胺的方法,其中R 1和R 3各自独立地为氢或具有1-4个C原子的烷基或 R2和R3与它们所键合的碳原子一起形成具有5或6个C原子的环,其中根据式II的相应的N-羟基 - (四氢 - 或六氢) - 邻苯二甲酰亚胺的盐: 其中R 1和R 3如上所定义,M是碱金属,与R1Cl作为烷基化剂接触,其中R1具有上述含义。 N-烷氧基 - (四或六氢) - 邻苯二甲酰亚胺可以随后借助于硫酸羟胺转化成相应的烷氧基胺,之后可以分离获得的烷氧基胺。 以这种方式,可以实现用于制备O-(m)乙基羟胺的简单和商业上有吸引力的方法。

    Process for the preparation of 2-cyanomethylcyclohexanone
    10.
    发明授权
    Process for the preparation of 2-cyanomethylcyclohexanone 失效
    2-氰基甲基环己酮的制备方法

    公开(公告)号:US4649211A

    公开(公告)日:1987-03-10

    申请号:US649653

    申请日:1984-09-12

    CPC分类号: C07C255/00

    摘要: The invention relates to a process for the preparation of 2-cyanomethylcyclohexanone by1. converting cyclohexanone to a Mannich base with a secondary amine salt and formaldehyde2. converting the Mannich base to the corresponding cyanohydrin with a cyanide3. pyrolysing the cyanohydrin obtained in step 2, wherein the pyrolysis of the cyanohydrin is carried out in the presence of a polar, aprotic solvent having a boiling point of more than 140.degree. C. and/or sodium cyanide.

    摘要翻译: 本发明涉及一种通过以下方法制备2-氰基甲基环己酮的方法:1.用仲胺盐和甲醛将环己酮转化为曼尼希碱。2.用氰化物将曼尼希碱转化为相应的氰醇3.热解步骤中获得的氰醇 2,其中氰醇的热解是在沸点高于140℃的极性非质子溶剂和/或氰化钠的存在下进行的。