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公开(公告)号：US5728892A
公开(公告)日：1998-03-17
申请号：US746162
申请日：1996-11-06
CPC分类号： C07C45/74
摘要： The invention relates to a method for preparing an .alpha.-alkylcinnamaldehyde via aldol concensation of a benzaldehyde and an alkanal, with pyrrolidine being employed as a catalyst. The method is suitable, in particular, for preparing .alpha.-hexylcinnamaldehyde by aldol condensation of benzaldehyde and n-octanal, in particular for preparing .alpha.-hexylcinnamaldehyde of olfactory quality, since it was found that, in the method according to the invention, relatively little .alpha.-hexyldecenal, the aldol condensation product of n-octanal, is formed. Preferably, the aldol condensation is carried out without a solvent in the presence of an acid, and the alkanal is metered in over time to a mixture which contains pyrrolidine and benzaldehyde.
摘要翻译： 本发明涉及通过苯甲醛和链烷醛的醛醇缩合制备α-烷基肉桂醛的方法，其中吡咯烷用作催化剂。 该方法特别适用于通过苯甲醛和正辛醛的醛醇缩合制备α-己基肉桂醛，特别是用于制备嗅觉质量的α-己基肉桂醛，因为发现在根据本发明的方法中，相对较少 形成正辛醛醛醛缩合产物α-正癸醛。 优选地，醛酸缩合在没有溶剂的情况下在酸的存在下进行，并且将烷醛随时间计量加入到含有吡咯烷和苯甲醛的混合物中。
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公开(公告)号：US5319125A
公开(公告)日：1994-06-07
申请号：US39745
申请日：1993-03-30
IPC分类号： B01J31/02 , B01J31/04 , C07B61/00 , C07C253/30 , C07C255/31
CPC分类号： C07C255/31
摘要： The invention relates to a method for the preparation of a 2-(2-cyanoethyl)-cyclopentanone by reaction of a cyclopentanone which contains at least one .alpha.-H atom with an .alpha.,.beta.-unsaturated nitrile in the presence of a catalytic amount of pyrrolidine as catalyst and optionally also a catalytic amount of an acid compound. A high selectivity and a high catalyst activity are achieved with the method.
摘要翻译： 本发明涉及一种通过在含有至少一个α-H原子的环戊酮与α，β-不饱和腈的反应中制备2-（2-氰乙基） - 环戊酮的方法， 吡咯烷作为催化剂和任选地还有催化量的酸化合物。 该方法可以实现高选择性和高催化活性。
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公开(公告)号：US5663433A
公开(公告)日：1997-09-02
申请号：US668074
申请日：1996-06-17
IPC分类号： C07C259/06 , C07C231/00
CPC分类号： C07C259/06
摘要： Process for the preparation of N-alkyl-N,O-diacetyl hydroxylamine, for instance N-methyl-N,O-diacetyl hydroxylamine, by catalytic reduction of a nitroalkane, for instance nitromethane, in the presence of acetic anhydride. As catalyst preferably a platinum on alumina catalyst is used. The invention provides a simple one-step process for the preparation of N-alkyl-N,O-diacetyl hydroxylamine in a relatively concentrated reaction medium.
摘要翻译： 在乙酸酐存在下，通过硝基烷烃例如硝基甲烷的催化还原来制备N-烷基-N，O-二乙酰基羟胺，例如N-甲基-N，O-二乙酰基羟胺的方法。 作为催化剂，优选使用氧化铝上的催化剂。 本发明提供了在相对浓缩的反应介质中制备N-烷基-N，O-二乙酰羟胺的简单的一步法。
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公开(公告)号：US5811588A
公开(公告)日：1998-09-22
申请号：US834456
申请日：1997-04-16
IPC分类号： C07B61/00 , C07C45/62 , C07C47/228 , C07C51/235 , C07C51/255 , C07C57/30
CPC分类号： C07C45/62 , C07C51/235
摘要： Process for the preparation of 3-phenylpropanal in which cinnamaldehyde is hydrogenated with the aid of a Pd-containing catalyst in the presence of a small amount of water. A high yield and a high selectivity are obtained in a commercially attractive process. The reaction mixture obtained can without intermediate further processing be subjected to an oxidation in which the cinnamaldehyde is oxidized to 3-phenylpropionic acid with a high degree of conversion and a high selectivity. The combination of the two process steps constitutes a simple, commercially attractive process for the preparation of 3-phenylpropionic acid using cinnamaldehyde as a starting material. The resulting 3-phenyl-propionic acid product may serve as an intermediate reagent in the synthesis of anti-viral pharmaceuticals, particularly HIV protease inhibitors.
摘要翻译： 制备3-苯基丙醛的方法，其中肉碱醛在少量水存在的情况下借助含Pd催化剂氢化。 在商业上有吸引力的工艺中获得高产率和高选择性。 所获得的反应混合物不经中间进一步处理，其中肉桂醛以高转化率和高选择性氧化成3-苯基丙酸。 两个工艺步骤的组合构成了使用肉桂醛作为起始原料制备3-苯基丙酸的简单的，商业上有吸引力的方法。 所得3-苯基 - 丙酸产物可用作合成抗病毒药物，特别是HIV蛋白酶抑制剂的中间试剂。
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公开(公告)号：US5610268A
公开(公告)日：1997-03-11
申请号：US486294
申请日：1995-06-07
申请人： Egbert W. Meijer , Hubertus J. M. Bosman , Franciscus H. A. M. J. Vandenbooren , Ellen M. M. De Brabander-Van Den Berg , Anna M. C. F. Castelijns , Hendrikus C. J. De Man , Rafael W. E. G. Reintjens , Christiaan J. C. Stoelwinder , Atze J. Nijenhuis
发明人： Egbert W. Meijer , Hubertus J. M. Bosman , Franciscus H. A. M. J. Vandenbooren , Ellen M. M. De Brabander-Van Den Berg , Anna M. C. F. Castelijns , Hendrikus C. J. De Man , Rafael W. E. G. Reintjens , Christiaan J. C. Stoelwinder , Atze J. Nijenhuis
IPC分类号： C08G73/02 , C08G83/00 , C08L101/00 , C09D201/00 , C08G63/44 , C08G73/00
CPC分类号： C08G83/003 , C08G73/0206 , C08G73/0213 , C08L101/005 , C09D201/005 , Y10S424/16
摘要： The invention relates to a dendritic macromolecule comprising a core and branches emanating from the core wherein the branches are based on vinyl cyanide and/or fumaryl dinatrile units. The invention also relates to processes for preparing these dendritic macromolecules. The dendritic macromolecules according to the invention are not sensitive to degradation through hydrolysis reactions and are also very stable at a high temperature. The processes are very suitable for large scale production of the dendritic macromolecules without requiring purification of reaction intermediates.
摘要翻译： 本发明涉及一种树枝状大分子，其包含核心和从芯发出的分支，其中分支基于乙烯基氰化物和/或富马酰二腈单元。 本发明还涉及制备这些树枝状大分子的方法。 根据本发明的树枝状大分子对通过水解反应的降解不敏感，并且在高温下也非常稳定。 该方法非常适合大规模生产树枝状大分子而不需要纯化反应中间体。
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6.发明授权Method for the preparation of a N-alkoxy-(tetra-or hexahydro)-phthalimide and method for the preparation of a N-alkoxyamine 失效制备N-烷氧基 - （四或六氢） - 邻苯二甲酰亚胺的方法及其制备方法
公开(公告)号：US5824804A
公开(公告)日：1998-10-20
申请号：US928126
申请日：1997-09-12
IPC分类号： C07D209/48
CPC分类号： C07D209/48 , Y02P20/582
摘要： Method for the preparation of N-alkoxy-(tetra- or hexahydro)-phthalimide according to formula I ##STR1## R.sub.1 being methyl or ethyl and R.sub.2 and R.sub.3 being each independently of one another hydrogen or alkyl with 1-4 C atoms or R.sub.2 and R.sub.3 together with the carbon atom to which they are bonded forming a ring with 5 or 6 C atoms, wherein the salt of the corresponding N-hydroxy-(tetrahydro- or hexahydro)-phthalimide according to formula II: ##STR2## with R.sub.2 and R.sub.3 as defined above and M being an alkali metal, is brought into contact with R.sub.1 Cl as alkylating agent, wherein R.sub.1 has the aforementioned meaning. The N-alkoxy-(tetra- or hexahydro)-phthalimide can afterwards be converted with the aid of hydroxylamine sulphate into the corresponding alkoxyamine after which the alkoxyamine obtained can be isolated. In this manner a simple and commercially attractive process for the preparation of O-(m)ethylhydroxylamine can be implemented.
摘要翻译： 用于制备式I的N-烷氧基 - （四或六氢） - 邻苯二甲酰亚胺的方法，其中R 1和R 3各自独立地为氢或具有1-4个C原子的烷基或 R2和R3与它们所键合的碳原子一起形成具有5或6个C原子的环，其中根据式II的相应的N-羟基 - （四氢 - 或六氢） - 邻苯二甲酰亚胺的盐： 其中R 1和R 3如上所定义，M是碱金属，与R1Cl作为烷基化剂接触，其中R1具有上述含义。 N-烷氧基 - （四或六氢） - 邻苯二甲酰亚胺可以随后借助于硫酸羟胺转化成相应的烷氧基胺，之后可以分离获得的烷氧基胺。 以这种方式，可以实现用于制备O-（m）乙基羟胺的简单和商业上有吸引力的方法。
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公开(公告)号：US5274165A
公开(公告)日：1993-12-28
申请号：US894430
申请日：1992-06-05
IPC分类号： C07C253/30 , C07C255/35
CPC分类号： C07C255/35
摘要： Process for the .alpha.-chlorination of phenylacetonitriles, for example benzyl cyanide, in which the phenylacetonitrile is contacted with a suitable chlorinating agent, sulphuryl chloride or chlorine gas, while an amount of strong acid, preferably HCl, is also present in the reaction mixture. The induction time and the reaction rate are dependent on, among other factors, the concentration of the acid. Preferably, the reaction is carried out under pressure. The reaction is well controllable.
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公开(公告)号：US4649211A
公开(公告)日：1987-03-10
申请号：US649653
申请日：1984-09-12
IPC分类号： C07B61/00 , B01J27/00 , B01J27/26 , C07C67/00 , C07C253/00 , C07C255/46 , C07C120/00 , C07C121/46
CPC分类号： C07C255/00
摘要： The invention relates to a process for the preparation of 2-cyanomethylcyclohexanone by1. converting cyclohexanone to a Mannich base with a secondary amine salt and formaldehyde2. converting the Mannich base to the corresponding cyanohydrin with a cyanide3. pyrolysing the cyanohydrin obtained in step 2, wherein the pyrolysis of the cyanohydrin is carried out in the presence of a polar, aprotic solvent having a boiling point of more than 140.degree. C. and/or sodium cyanide.
摘要翻译： 本发明涉及一种通过以下方法制备2-氰基甲基环己酮的方法：1.用仲胺盐和甲醛将环己酮转化为曼尼希碱。2.用氰化物将曼尼希碱转化为相应的氰醇3.热解步骤中获得的氰醇 2，其中氰醇的热解是在沸点高于140℃的极性非质子溶剂和/或氰化钠的存在下进行的。
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公开(公告)号：US5786507A
公开(公告)日：1998-07-28
申请号：US834380
申请日：1997-04-16
CPC分类号： C07C45/62 , C07C51/235
摘要： Process for the preparation of 3-phenylpropionic acid in which 3-phenylpropanal is subjected to an oxidation, at elevated temperature, in particular at a temperature of between 40.degree. and 80.degree. C., using a medium containing molecular oxygen. A high degree of conversion and a high selectivity are obtained. The starting material 3-phenylpropanal can be prepared in a suitable manner through the hydrogenation of cinnamaldehyde in the presence of a Pd-containing catalyst, after which the reaction mixture obtained can without intermediate further processing be used in the oxidation reaction. The combination of the two process steps constitutes a simple, commercially attractive process for the preparation of 3-phenylpropionic acid using cinnamaldehyde as a starting material. 3-phenylpropionic acid can be used in particular in the preparation of pharmaceuticals such as HIV protease inhibitors.
摘要翻译： 制备3-苯基丙酸的方法，其中3-苯基丙醛在升高的温度下，特别是在40℃至80℃的温度下，使用含有分子氧的培养基进行氧化。 获得高转化率和高选择性。 原料3-苯基丙醛可以通过在含Pd催化剂的存在下氢化肉桂醛以合适的方式制备，之后得到的反应混合物无需中间进一步处理即可用于氧化反应。 两个工艺步骤的组合构成了使用肉桂醛作为起始原料制备3-苯基丙酸的简单的，商业上有吸引力的方法。 3-苯基丙酸特别可用于制备药物如HIV蛋白酶抑制剂。
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公开(公告)号：US5616804A
公开(公告)日：1997-04-01
申请号：US560510
申请日：1995-11-17
IPC分类号： C07C209/26 , C07C209/78
CPC分类号： C07C209/26
摘要： The present process involves preparing dibenzylamine through the hydrogenation of benzaldehyde in the presence of ammonia and a catalyst containing palladium using a small amount of solvent or dispersion medium. With the present process, dibenzylamine can be prepared with high selectivity in a relatively short reaction time and with complete conversion of the benzaldehyde, at which makes it commercially attractive. In the present process, a palladium-carbon catalyst is preferably used.
摘要翻译： 本方法涉及通过使用少量溶剂或分散介质在氨的存在下通过苯甲醛的氢化和含钯的催化剂来制备二苄基胺。 通过本发明方法，可以在相当短的反应时间内以及完全转化苯甲醛以高选择性制备二苄基胺，从而使其具有商业上的吸引力。 在本方法中，优选使用钯 - 碳催化剂。
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