公开(公告)号：US20140134258A1

公开(公告)日：2014-05-15

申请号：US13884123

申请日：2011-11-08

申请人： Anna Tampieri ,  Simone Sprio ,  Andrea Ruffini ,  Julia Will ,  Peter Greil ,  Frank Muller ,  Julian Martinez Fernandez ,  Carmen Torres Raya ,  Francisco Manuel Varela Feria ,  Joaquin Ramirez Rico ,  Marie-Francoise Harmand

发明人： Anna Tampieri ,  Simone Sprio ,  Andrea Ruffini ,  Julia Will ,  Peter Greil ,  Frank Muller ,  Julian Martinez Fernandez ,  Carmen Torres Raya ,  Francisco Manuel Varela Feria ,  Joaquin Ramirez Rico ,  Marie-Francoise Harmand

IPC分类号： A61K9/50 ,  A61K38/39 ,  A61F2/28

CPC分类号： A61K9/501 ,  A61F2/28 ,  A61K38/39 ,  A61L27/10 ,  A61L27/12 ,  A61L27/46 ,  A61L27/56 ,  A61L2430/02

摘要： The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibres and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.

摘要翻译： 本发明涉及包含由至少一种多孔木材获得的基于羟基磷灰石（HA）的核心或基于胶原纤维和羟基磷灰石的骨替代物，以及基于羟基磷灰石（HA）或碳化硅（SiC）的壳， 从至少一种具有比芯的至少一个木材低的孔隙率的木材获得。 多孔木材具有总孔隙率在60％至95％之间，优选在65％至85％之间，并且选自藤藤，松木，巴伐木和轻木的选择。 壳的木材具有20％至60％之间的孔隙率，优选30％至50％之间。 骨替代物用于骨的替代和再生，优选用于经受机械负荷的骨骼，例如腿和臂的长骨，优选胫骨，跖骨，股骨，肱骨或半径的骨骼。

公开(公告)号：US09326948B2

公开(公告)日：2016-05-03

申请号：US13884123

申请日：2011-11-08

申请人： Anna Tampieri ,  Simone Sprio ,  Andrea Ruffini ,  Julia Will ,  Peter Greil ,  Frank Muller ,  Julian Martinez Fernandez ,  Carmen Torres Raya ,  Francisco Manuel Varela Feria ,  Joaquin Ramirez Rico ,  Marie-Francoise Harmand

发明人： Anna Tampieri ,  Simone Sprio ,  Andrea Ruffini ,  Julia Will ,  Peter Greil ,  Frank Muller ,  Julian Martinez Fernandez ,  Carmen Torres Raya ,  Francisco Manuel Varela Feria ,  Joaquin Ramirez Rico ,  Marie-Francoise Harmand

IPC分类号： A61F2/28 ,  A61K38/39 ,  A61L27/10 ,  A61L27/12 ,  A61L27/46 ,  A61K9/50 ,  A61L27/56

CPC分类号： A61K9/501 ,  A61F2/28 ,  A61K38/39 ,  A61L27/10 ,  A61L27/12 ,  A61L27/46 ,  A61L27/56 ,  A61L2430/02

摘要： The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibers and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.

摘要翻译： 本发明涉及包含由至少一种多孔木材获得的基于羟基磷灰石（HA）的核心或基于胶原纤维和羟基磷灰石的骨替代物，以及基于羟基磷灰石（HA）或碳化硅（SiC）的壳， 从至少一种具有比芯的至少一个木材低的孔隙率的木材获得。 多孔木材具有总孔隙率在60％至95％之间，优选在65％至85％之间，并且选自藤藤，松木，巴伐木和轻木的选择。 壳的木材具有20％至60％之间的孔隙率，优选30％至50％之间。 骨替代物用于骨的取代和再生，优选用于经受机械负荷的骨骼，例如腿和臂的长骨，优选胫骨，跖骨，股骨，肱骨或半径的骨骼。