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1.发明申请IMPLANTS FOR "LOAD BEARING" BONE SUBSTITUTIONS HAVING HIERARCHICAL ORGANIZED ARCHITECTURE DERIVING FROM TRANSFORMATION OF VEGETAL STRUCTURES 有权用于“负荷轴承”的植入物具有由植物结构转化而衍生的分层结构的骨骼替代物公开(公告)号：US20140134258A1
公开(公告)日：2014-05-15
申请号：US13884123
申请日：2011-11-08
申请人： Anna Tampieri , Simone Sprio , Andrea Ruffini , Julia Will , Peter Greil , Frank Muller , Julian Martinez Fernandez , Carmen Torres Raya , Francisco Manuel Varela Feria , Joaquin Ramirez Rico , Marie-Francoise Harmand
发明人： Anna Tampieri , Simone Sprio , Andrea Ruffini , Julia Will , Peter Greil , Frank Muller , Julian Martinez Fernandez , Carmen Torres Raya , Francisco Manuel Varela Feria , Joaquin Ramirez Rico , Marie-Francoise Harmand
CPC分类号： A61K9/501 , A61F2/28 , A61K38/39 , A61L27/10 , A61L27/12 , A61L27/46 , A61L27/56 , A61L2430/02
摘要： The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibres and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.
摘要翻译： 本发明涉及包含由至少一种多孔木材获得的基于羟基磷灰石（HA）的核心或基于胶原纤维和羟基磷灰石的骨替代物，以及基于羟基磷灰石（HA）或碳化硅（SiC）的壳， 从至少一种具有比芯的至少一个木材低的孔隙率的木材获得。 多孔木材具有总孔隙率在60％至95％之间，优选在65％至85％之间，并且选自藤藤，松木，巴伐木和轻木的选择。 壳的木材具有20％至60％之间的孔隙率，优选30％至50％之间。 骨替代物用于骨的替代和再生，优选用于经受机械负荷的骨骼，例如腿和臂的长骨，优选胫骨，跖骨，股骨，肱骨或半径的骨骼。
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2.发明授权Implants for “load bearing” bone substitutions having hierarchical organized architecture deriving from transformation of vegetal structures 有权用于“承载”骨替代的植入物，其具有由植物结构转化产生的等级有组织的结构公开(公告)号：US09326948B2
公开(公告)日：2016-05-03
申请号：US13884123
申请日：2011-11-08
申请人： Anna Tampieri , Simone Sprio , Andrea Ruffini , Julia Will , Peter Greil , Frank Muller , Julian Martinez Fernandez , Carmen Torres Raya , Francisco Manuel Varela Feria , Joaquin Ramirez Rico , Marie-Francoise Harmand
发明人： Anna Tampieri , Simone Sprio , Andrea Ruffini , Julia Will , Peter Greil , Frank Muller , Julian Martinez Fernandez , Carmen Torres Raya , Francisco Manuel Varela Feria , Joaquin Ramirez Rico , Marie-Francoise Harmand
CPC分类号： A61K9/501 , A61F2/28 , A61K38/39 , A61L27/10 , A61L27/12 , A61L27/46 , A61L27/56 , A61L2430/02
摘要： The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibers and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.
摘要翻译： 本发明涉及包含由至少一种多孔木材获得的基于羟基磷灰石（HA）的核心或基于胶原纤维和羟基磷灰石的骨替代物，以及基于羟基磷灰石（HA）或碳化硅（SiC）的壳， 从至少一种具有比芯的至少一个木材低的孔隙率的木材获得。 多孔木材具有总孔隙率在60％至95％之间，优选在65％至85％之间，并且选自藤藤，松木，巴伐木和轻木的选择。 壳的木材具有20％至60％之间的孔隙率，优选30％至50％之间。 骨替代物用于骨的取代和再生，优选用于经受机械负荷的骨骼，例如腿和臂的长骨，优选胫骨，跖骨，股骨，肱骨或半径的骨骼。
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3.发明申请Plurisubstituted Hydroxyapatite and the Composite Thereof With a Natural and/or Synthetic Polymer, Their Preparation and Uses Thereof 有权天然和/或合成聚合物的多取代羟基磷灰石及其复合物及其制备及其用途公开(公告)号：US20080262121A1
公开(公告)日：2008-10-23
申请号：US12089887
申请日：2006-10-12
申请人： Elena Landi , Anna Tampieri , Giancarlo Celotti , Simone Sprio , Daniele Pressato , Claudio De Luca
发明人： Elena Landi , Anna Tampieri , Giancarlo Celotti , Simone Sprio , Daniele Pressato , Claudio De Luca
CPC分类号： C01B25/322 , A61F2/28 , A61F2310/00293 , A61L27/12 , A61L27/46 , C01B25/16
摘要： The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses .
摘要翻译： 本发明涉及多生物相容性离子物质的多羟基磷灰石，及其与天然和/或合成聚合物的生物杂交复合物，其可用于制备用于治疗骨组织缺陷的仿生骨替代物。 此外，本发明涉及其制备方法和用途。
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4.发明授权Plurisubstituted hydroxyapatite and the composite thereof with a natural and/or synthetic polymer, their preparation and uses thereof 有权多取代羟基磷灰石及其与天然和/或合成聚合物的复合物及其制备及用途公开(公告)号：US09327976B2
公开(公告)日：2016-05-03
申请号：US12089887
申请日：2006-10-12
申请人： Elena Landi , Anna Tampieri , Giancarlo Celotti , Simone Sprio , Daniele Pressato , Claudio De Luca
发明人： Elena Landi , Anna Tampieri , Giancarlo Celotti , Simone Sprio , Daniele Pressato , Claudio De Luca
CPC分类号： C01B25/322 , A61F2/28 , A61F2310/00293 , A61L27/12 , A61L27/46 , C01B25/16
摘要： The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses.
摘要翻译： 本发明涉及多生物相容性离子物质的多羟基磷灰石，及其与天然和/或合成聚合物的生物杂交复合物，其可用于制备用于治疗骨组织缺陷的仿生骨替代物。 此外，本发明涉及其制备方法和用途。
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