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1.发明授权Implants for “load bearing” bone substitutions having hierarchical organized architecture deriving from transformation of vegetal structures 有权用于“承载”骨替代的植入物，其具有由植物结构转化产生的等级有组织的结构公开(公告)号：US09326948B2
公开(公告)日：2016-05-03
申请号：US13884123
申请日：2011-11-08
申请人： Anna Tampieri , Simone Sprio , Andrea Ruffini , Julia Will , Peter Greil , Frank Muller , Julian Martinez Fernandez , Carmen Torres Raya , Francisco Manuel Varela Feria , Joaquin Ramirez Rico , Marie-Francoise Harmand
发明人： Anna Tampieri , Simone Sprio , Andrea Ruffini , Julia Will , Peter Greil , Frank Muller , Julian Martinez Fernandez , Carmen Torres Raya , Francisco Manuel Varela Feria , Joaquin Ramirez Rico , Marie-Francoise Harmand
CPC分类号： A61K9/501 , A61F2/28 , A61K38/39 , A61L27/10 , A61L27/12 , A61L27/46 , A61L27/56 , A61L2430/02
摘要： The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibers and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.
摘要翻译： 本发明涉及包含由至少一种多孔木材获得的基于羟基磷灰石（HA）的核心或基于胶原纤维和羟基磷灰石的骨替代物，以及基于羟基磷灰石（HA）或碳化硅（SiC）的壳， 从至少一种具有比芯的至少一个木材低的孔隙率的木材获得。 多孔木材具有总孔隙率在60％至95％之间，优选在65％至85％之间，并且选自藤藤，松木，巴伐木和轻木的选择。 壳的木材具有20％至60％之间的孔隙率，优选30％至50％之间。 骨替代物用于骨的取代和再生，优选用于经受机械负荷的骨骼，例如腿和臂的长骨，优选胫骨，跖骨，股骨，肱骨或半径的骨骼。
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2.发明申请IMPLANTS FOR "LOAD BEARING" BONE SUBSTITUTIONS HAVING HIERARCHICAL ORGANIZED ARCHITECTURE DERIVING FROM TRANSFORMATION OF VEGETAL STRUCTURES 有权用于“负荷轴承”的植入物具有由植物结构转化而衍生的分层结构的骨骼替代物公开(公告)号：US20140134258A1
公开(公告)日：2014-05-15
申请号：US13884123
申请日：2011-11-08
申请人： Anna Tampieri , Simone Sprio , Andrea Ruffini , Julia Will , Peter Greil , Frank Muller , Julian Martinez Fernandez , Carmen Torres Raya , Francisco Manuel Varela Feria , Joaquin Ramirez Rico , Marie-Francoise Harmand
发明人： Anna Tampieri , Simone Sprio , Andrea Ruffini , Julia Will , Peter Greil , Frank Muller , Julian Martinez Fernandez , Carmen Torres Raya , Francisco Manuel Varela Feria , Joaquin Ramirez Rico , Marie-Francoise Harmand
CPC分类号： A61K9/501 , A61F2/28 , A61K38/39 , A61L27/10 , A61L27/12 , A61L27/46 , A61L27/56 , A61L2430/02
摘要： The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibres and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.
摘要翻译： 本发明涉及包含由至少一种多孔木材获得的基于羟基磷灰石（HA）的核心或基于胶原纤维和羟基磷灰石的骨替代物，以及基于羟基磷灰石（HA）或碳化硅（SiC）的壳， 从至少一种具有比芯的至少一个木材低的孔隙率的木材获得。 多孔木材具有总孔隙率在60％至95％之间，优选在65％至85％之间，并且选自藤藤，松木，巴伐木和轻木的选择。 壳的木材具有20％至60％之间的孔隙率，优选30％至50％之间。 骨替代物用于骨的替代和再生，优选用于经受机械负荷的骨骼，例如腿和臂的长骨，优选胫骨，跖骨，股骨，肱骨或半径的骨骼。
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3.发明申请Plurisubstituted Hydroxyapatite and the Composite Thereof With a Natural and/or Synthetic Polymer, Their Preparation and Uses Thereof 有权天然和/或合成聚合物的多取代羟基磷灰石及其复合物及其制备及其用途公开(公告)号：US20080262121A1
公开(公告)日：2008-10-23
申请号：US12089887
申请日：2006-10-12
申请人： Elena Landi , Anna Tampieri , Giancarlo Celotti , Simone Sprio , Daniele Pressato , Claudio De Luca
发明人： Elena Landi , Anna Tampieri , Giancarlo Celotti , Simone Sprio , Daniele Pressato , Claudio De Luca
CPC分类号： C01B25/322 , A61F2/28 , A61F2310/00293 , A61L27/12 , A61L27/46 , C01B25/16
摘要： The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses .
摘要翻译： 本发明涉及多生物相容性离子物质的多羟基磷灰石，及其与天然和/或合成聚合物的生物杂交复合物，其可用于制备用于治疗骨组织缺陷的仿生骨替代物。 此外，本发明涉及其制备方法和用途。
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4.发明授权Plurisubstituted hydroxyapatite and the composite thereof with a natural and/or synthetic polymer, their preparation and uses thereof 有权多取代羟基磷灰石及其与天然和/或合成聚合物的复合物及其制备及用途公开(公告)号：US09327976B2
公开(公告)日：2016-05-03
申请号：US12089887
申请日：2006-10-12
申请人： Elena Landi , Anna Tampieri , Giancarlo Celotti , Simone Sprio , Daniele Pressato , Claudio De Luca
发明人： Elena Landi , Anna Tampieri , Giancarlo Celotti , Simone Sprio , Daniele Pressato , Claudio De Luca
CPC分类号： C01B25/322 , A61F2/28 , A61F2310/00293 , A61L27/12 , A61L27/46 , C01B25/16
摘要： The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses.
摘要翻译： 本发明涉及多生物相容性离子物质的多羟基磷灰石，及其与天然和/或合成聚合物的生物杂交复合物，其可用于制备用于治疗骨组织缺陷的仿生骨替代物。 此外，本发明涉及其制备方法和用途。
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5.发明授权Cartilaginous and osteochondral substitute comprising multilayer structure and use thereof 有权软骨和骨软骨替代物，包括多层结构及其用途公开(公告)号：US09155818B2
公开(公告)日：2015-10-13
申请号：US11817172
申请日：2006-03-02
IPC分类号： A61L27/42 , A61L27/32 , A61L27/34 , A61L27/26 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/24 , A61L27/48 , A61L24/10
CPC分类号： A61L27/425 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/32 , A61L27/34 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , C08L89/06
摘要： The present invention relates to a multilayer structure (1) including a first upper layer (2) consisting of an organic matrix including collagen and at least a lower layer (3, 4, . . . 10) consisting of a composite matrix including hydroxylapatite and collagen. Furthermore, the present invention relates to a cartilaginous substitute including said multilayer structure (1) as well as an osteochondral substitute including said multilayer structure (1). Finally, the present invention relates to the use of said multilayer structure (1) for the preparation of said cartilaginous substitute and said osteochondral substitute for the treatment of cartilaginous defects and osteochondral defects or for the neo-formation of a cartilaginous tissue and/or a subchondral bone tissue.
摘要翻译： 本发明涉及一种多层结构（1），该多层结构（1）包括由包括胶原的有机基质和至少一层下层（3,4，...）构成的第一上层（2），所述下层由包括羟基磷灰石和 胶原。 此外，本发明涉及包括所述多层结构（1）的软骨替代物以及包括所述多层结构（1）的骨软骨替代物。 最后，本发明涉及所述多层结构（1）用于制备所述软骨替代物和所述骨软骨替代物用于治疗软骨缺损和骨软骨缺损或用于软骨组织和/或 软骨下骨组织。
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6.发明申请公开(公告)号：US20090232875A1
公开(公告)日：2009-09-17
申请号：US11817172
申请日：2006-03-02
CPC分类号： A61L27/425 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/32 , A61L27/34 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , C08L89/06
摘要： The present invention relates to a multilayer structure (1) including a first upper layer (2) consisting of an organic matrix including collagen and at least a lower layer (3, 4, . . . 10) consisting of a composite matrix including hydroxylapatite and collagen. Furthermore, the present invention relates to a cartilaginous substitute including said multilayer structure (1) as well as an osteochondral substitute including said multilayer structure (1). Finally, the present invention relates to the use of said multilayer structure (1) for the preparation of said cartilaginous substitute and said osteochondral substitute for the treatment of cartilaginous defects and osteochondral defects or for the neo-formation of a cartilaginous tissue and/or a subchondral bone tissue.
摘要翻译： 本发明涉及一种多层结构（1），该多层结构（1）包括由包括胶原的有机基质和至少一层下层（3,4，...）构成的第一上层（2），所述下层由包括羟基磷灰石和 胶原。 此外，本发明涉及包括所述多层结构（1）的软骨替代物以及包括所述多层结构（1）的骨软骨替代物。 最后，本发明涉及所述多层结构（1）用于制备所述软骨替代物和所述骨软骨替代物用于治疗软骨缺损和骨软骨缺陷或用于软骨组织和/或 软骨下骨组织。
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公开(公告)号：US09327027B2
公开(公告)日：2016-05-03
申请号：US13812741
申请日：2011-07-28
申请人： Anna Tampieri , Elena Landi , Monica Sandri , Daniele Pressato , José Rivas Rey , Manuel Banobre López , Maurilio Marcacci
发明人： Anna Tampieri , Elena Landi , Monica Sandri , Daniele Pressato , José Rivas Rey , Manuel Banobre López , Maurilio Marcacci
CPC分类号： A61K47/02 , A61K49/0002 , A61K49/08 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/02 , A61L2430/06 , C01B25/32 , C01B25/322 , C01B25/45 , C01P2004/62 , C01P2006/62 , C01P2006/64
摘要： The present invention relates to hydroxyapatite doped with Fe2+ ions and Fe3+ ions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume.The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.
摘要翻译： 本发明涉及掺杂有Fe2 +离子的羟基磷灰石和部分代替晶格中的钙离子的Fe 3+离子。 由于在HA的晶格中存在磁性纳米域，所以羟基磷灰石的特征在于通过施加34Oe的磁场测量的0.05至8emu / g的固有磁性，给定有限量的磁性次级 目前，少于约3％（体积）。 本征磁性羟基磷灰石可以在外部磁场的控制下装载由蛋白质，基因，干细胞，生长因子，血管形成因子，活性物质和药物组成的组中选择的生物物质作为载体和脱模剂 生物物质或药物，作为诊断或骨或骨软骨再生的造影剂。
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公开(公告)号：US20130129634A1
公开(公告)日：2013-05-23
申请号：US13812741
申请日：2011-07-28
申请人： Anna Tampieri , Elena Landi , Monica Sandri , Daniele Pressato , José Rivas Rey , Manuel Banobre Lopez , Maurilio Marcacci
发明人： Anna Tampieri , Elena Landi , Monica Sandri , Daniele Pressato , José Rivas Rey , Manuel Banobre Lopez , Maurilio Marcacci
CPC分类号： A61K47/02 , A61K49/0002 , A61K49/08 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/02 , A61L2430/06 , C01B25/32 , C01B25/322 , C01B25/45 , C01P2004/62 , C01P2006/62 , C01P2006/64
摘要： The present invention relates to hydroxyapatite doped with Fe2+ ions and Fe3+ ions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume.The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.
摘要翻译： 本发明涉及掺杂有Fe2 +离子的羟基磷灰石和部分代替晶格中的钙离子的Fe 3+离子。 由于在HA的晶格中存在磁性纳米域，所以羟基磷灰石的特征在于通过施加34Oe的磁场测量的0.05至8emu / g的固有磁性，给定有限量的磁性次级 目前，少于约3％（体积）。 本征磁性羟基磷灰石可以在外部磁场的控制下装载由蛋白质，基因，干细胞，生长因子，血管形成因子，活性物质和药物组成的组中选择的生物物质作为载体和脱模剂 生物物质或药物，作为诊断或骨或骨软骨再生的造影剂。
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9.发明申请Pin for Anchorage of Articular Prosthesis, Articular Prosthesis Comprising Said Pin, Tibial Component and Articular Prosthesis for the Knee Comprising Said Tibial Component 审中-公开关节假体的固定针，包括所述胫骨部件的膝部的所述针，胫骨部件和关节假体的关节假体公开(公告)号：US20080200957A1
公开(公告)日：2008-08-21
申请号：US12065039
申请日：2006-09-04
IPC分类号： A61B17/56
CPC分类号： A61F2/30721 , A61F2/30749 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4202 , A61F2002/30014 , A61F2002/30113 , A61F2002/30115 , A61F2002/30125 , A61F2002/30133 , A61F2002/30138 , A61F2002/30153 , A61F2002/30156 , A61F2002/30235 , A61F2002/30332 , A61F2002/30405 , A61F2002/30451 , A61F2002/30487 , A61F2002/305 , A61F2002/30571 , A61F2002/30579 , A61F2002/30593 , A61F2002/30604 , A61F2002/30772 , A61F2002/30785 , A61F2002/30787 , A61F2002/30797 , A61F2002/30805 , A61F2002/30822 , A61F2002/30841 , A61F2002/30878 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30894 , A61F2002/30957 , A61F2002/3895 , A61F2220/0025 , A61F2220/0033 , A61F2220/0058 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0017 , A61F2230/0019 , A61F2230/0023 , A61F2230/0069 , A61F2250/0018 , A61F2310/00023 , A61F2310/00179 , A61F2310/00293
摘要： A pin for the anchoring of articular prostheses includes a connecting portion (4) with a prosthesis (2) and an engagement portion (5) in a hole obtained within a bone. The engagement portion (5) is at least partly deformable in a radial direction and in a resilient way, in order to allow the instantaneous blocking of the pin (1) in the hole and the primary fixing of the prosthesis (2) on the bone, so as to al low an easy primary fixing of the prosthesis by simply introducing with a pressure the connecting portion in the hole obtained within the bone itself.
摘要翻译： 用于锚固关节假体的销包括在骨头内获得的孔中具有假体（2）和接合部分（5）的连接部分（4）。 接合部分（5）可在径向方向和弹性方向上至少部分地变形，以便允许销（1）在孔中的瞬时阻塞以及假体（2）在骨头上的主要固定 ，以便通过简单地在骨骼内部获得的孔中的连接部分的压力简单地引入假体来简化主要固定。
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