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公开(公告)号：US20100074893A1
公开(公告)日：2010-03-25
申请号：US12421836
申请日：2009-04-10
IPC分类号： A61K39/395 , C07K16/00 , C12N5/16 , C12P21/06 , G01N33/53 , G01N33/566
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/92 , G01N33/574 , G01N33/57415 , G01N33/57449
摘要： The invention provides isolated anti-ECM-complex antibodies that bind to ECM-complexes. The invention also encompasses compositions comprising an anti-ECM-complex antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-ECM-complex antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-ECM-complex antibodies. The invention encompasses a method of producing the anti-ECM-complex antibodies. Other aspects of the invention are a method of detecting an ECM-complex expressing cancer, a method of inhibiting growth of an ECM-complex-expressing tumor, and a method of alleviating or treating an ECM-complex-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-ECM-complex antibody to the mammal.
摘要翻译： 本发明提供了结合ECM-复合物的分离的抗ECM-复合物抗体。 本发明还包括包含抗ECM复合物抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗ECM-复合物抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供了产生抗ECM复合物抗体的细胞。 本发明包括产生抗ECM复合物抗体的方法。 本发明的其它方面是检测ECM-复合物表达癌症的方法，抑制表达ECM-复合物的肿瘤生长的方法，以及减轻或治疗哺乳动物中表达ECM-复合物的癌症的方法，包括 向哺乳动物施用治疗有效量的抗ECM-复合物抗体。
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公开(公告)号：US06967093B2
公开(公告)日：2005-11-22
申请号：US09816825
申请日：2001-03-22
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00
摘要： A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith.
摘要翻译： 提供了在高内皮细胞（GST-3）中表达的新型人类糖基转移酶及与其相关的多肽，以及编码其的核酸组合物。 主题多肽和核酸组合物可用于各种应用，包括研究，诊断和治疗剂筛选应用。 还提供了抑制选择素介导的结合事件的方法和治疗与之相关的疾病状况的方法。
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3.发明授权Method of determining whether an agent modulates glycosyl sulfotransferase-3 失效确定药剂是否调节糖基磺基转移酶-3的方法公开(公告)号：US06365365B1
公开(公告)日：2002-04-02
申请号：US09190911
申请日：1998-11-12
IPC分类号： C12Q148
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00
摘要： A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-3 or KSGal6ST, or homologues thereof.
摘要翻译： 提供了在高内皮细胞（GST-3）中表达的新型人类糖基转移酶及与其相关的多肽，以及编码其的核酸组合物。 主题多肽和核酸组合物可用于各种应用，包括研究，诊断和治疗剂筛选应用。 还提供了抑制选择素介导的结合事件的方法和治疗与其相关的疾病状况的方法，特别是通过施用GST-3或KSGal6ST中的至少一种的抑制剂或其同系物。
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公开(公告)号：US06933142B1
公开(公告)日：2005-08-23
申请号：US09645078
申请日：2000-08-23
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61K48/00 , A61P29/00 , A61P37/06 , A61P43/00 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/54 , C12Q1/48 , C07K14/435
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00
摘要： Mammalian glycosylsulfotransferases expressed in high endothelial cells (HEC-GLCNAC6ST) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of HEC-GLCNAC6ST or KSGal6ST, or homologues thereof.
摘要翻译： 提供了在高内皮细胞（HEC-GLCNAC6ST）中表达的哺乳动物糖基转移酶和与其相关的多肽，以及编码其的核酸组合物。 主题多肽和核酸组合物可用于各种应用，包括诊断和治疗剂筛选应用。 还提供了抑制选择素介导的结合事件的方法和治疗与之相关的疾病状况的方法，特别是通过施用HEC-GLCNAC6ST或KSGal6ST中的至少一种的抑制剂或其同系物。
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公开(公告)号：US06844175B2
公开(公告)日：2005-01-18
申请号：US10007262
申请日：2001-11-08
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61K48/00 , A61P29/00 , A61P37/06 , A61P43/00 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/54 , C12Q1/48 , C07H21/02 , C07K14/435
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00
摘要： A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-3 or KSGal6ST, or homologues thereof
摘要翻译： 提供了在高内皮细胞（GST-3）中表达的新型人类糖基转移酶及与其相关的多肽，以及编码其的核酸组合物。 本发明的多肽和核酸可用于各种应用，包括研究，诊断和治疗剂筛选应用。 还提供了抑制选择素介导的结合事件的方法和治疗与之相关的疾病状况的方法，特别是通过施用GST-3或KSGal6ST中的至少一种或其同系物的抑制剂
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公开(公告)号：US06265192B1
公开(公告)日：2001-07-24
申请号：US09045284
申请日：1998-03-20
IPC分类号： C12P2106
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00
摘要： A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith.
摘要翻译： 提供了在高内皮细胞（GST-3）中表达的新型人类糖基转移酶及与其相关的多肽，以及编码其的核酸组合物。 主题多肽和核酸组合物可用于各种应用，包括研究，诊断和治疗剂筛选应用。 还提供了抑制选择素介导的结合事件的方法和治疗与之相关的疾病状况的方法。
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