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21 条记录 (耗时 0.032 秒)

    Method of treating certain indications associated with hyperglycemia
    3.
    发明授权
    Method of treating certain indications associated with hyperglycemia 失效
    治疗与高血糖相关的某些适应症的方法

    公开(公告)号：US06440749B1

    公开(公告)日：2002-08-27

    申请号：US09470482

    申请日：1999-12-22

    申请人： Anthony Cerami ,  Peter C. Ulrich ,  Dilip R. Wagle ,  San-Bao Hwang ,  Sara Vasan ,  John J. Egan

    发明人： Anthony Cerami ,  Peter C. Ulrich ,  Dilip R. Wagle ,  San-Bao Hwang ,  Sara Vasan ,  John J. Egan

    IPC分类号： C07D27762

    CPC分类号： G01N33/6842 ,  A61K8/49 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07D277/22 ,  C07D277/40 ,  G01N33/68 ,  G01N33/6854 ,  G01N2500/02

    摘要： The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

    摘要翻译： 本发明涉及用于抑制和逆转非酶交联（蛋白质老化）的组合物和方法。 因此，公开了包含能够抑制靶蛋白的高级糖基化终产物形成的试剂的组合物，并且还通过切割高级糖基化终产物中存在的基于α-二羰基的蛋白质交联来进一步反转高级糖基化终产物中的预形成交联 。 有用的某些试剂是噻唑鎓盐。 该方法包括使靶蛋白与组合物接触。 预想到本发明的工业和治疗应用，因为可以处理食物腐败和动物蛋白质老化。 还公开了用于检测非酶交联反转的免疫测定。

    Preventing and reversing the formation of advance glycosylation endproducts
    6.
    发明授权
    Preventing and reversing the formation of advance glycosylation endproducts 失效
    预防和逆转先进的糖基化终产物的形成

    公开(公告)号：US07022719B2

    公开(公告)日：2006-04-04

    申请号：US10418398

    申请日：2003-04-18

    申请人： Anthony Cerami ,  Peter C. Ulrich ,  Dilip R. Wagle ,  San-Bao Hwang ,  Sara Vasan ,  John J. Egan

    发明人： Anthony Cerami ,  Peter C. Ulrich ,  Dilip R. Wagle ,  San-Bao Hwang ,  Sara Vasan ,  John J. Egan

    IPC分类号： A61K31/426 ,  C07D277/20

    CPC分类号： G01N33/6842 ,  A61K8/49 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07D277/22 ,  C07D277/40 ,  G01N33/68 ,  G01N33/6854 ,  G01N2500/02

    摘要： The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

    摘要翻译： 本发明涉及用于抑制和逆转非酶交联（蛋白质老化）的组合物和方法。 因此，公开了包含能够抑制靶蛋白的高级糖基化终产物形成的试剂的组合物，并且还通过切割高级糖基化终产物中存在的基于α-二羰基的蛋白质交联来进一步反转高级糖基化终产物中的预形成交联 。 某些有用的试剂是噻唑鎓盐。 该方法包括使靶蛋白与组合物接触。 预想到本发明的工业和治疗应用，因为可以处理食物腐败和动物蛋白质老化。 还公开了用于检测非酶交联反转的新型免疫测定。