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1.发明申请Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances 有权干粉吸入器，相关的吸塑包装分选和打开机构，以及分配干粉物质的相关方法公开(公告)号：US20050103337A1
公开(公告)日：2005-05-19
申请号：US10970154
申请日：2004-10-21
申请人： Anthony James Hickey , Timothy Crowder , Jeffrey Warden , Keith Arthur Johnson , Mark Ketner , Jay Fording , Michael Garten , William Riley , Sean Anderson , Bruce Ferris , Paul Rockwell
发明人： Anthony James Hickey , Timothy Crowder , Jeffrey Warden , Keith Arthur Johnson , Mark Ketner , Jay Fording , Michael Garten , William Riley , Sean Anderson , Bruce Ferris , Paul Rockwell
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/001 , A61M15/0023 , A61M15/0038 , A61M15/0048 , A61M15/0078 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/0085 , A61M2202/064 , A61M2205/18 , A61M2205/43 , A61M2205/44 , A61M2205/581 , A61M2205/584
摘要： Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.
摘要翻译： 具有用于分配可吸入干粉的药物级制剂的多剂量干粉末包装的干粉吸入器包括：（a）泡罩包装，其上包括多个间隔开的密封泡罩，每个泡罩具有突出的天花板和限定 泡罩通道在其间，其中包含干粉; （b）在其前部保持叶片的可动刀片盒; 和（c）连接到可动刀片盒的可延伸的接口。 在操作中，用户向外拉出接口管，然后将吸嘴向内拉，以使吸塑包装前进，以将泡罩定位在吸入器中选定的分配位置，并使刀片盒将刀片移动穿过保持在 吸入器中的分配位置，从而打开保持在分配位置的泡罩。
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2.发明申请Blister packages with frames and associated methods of fabricating dry powder drug containment systems 有权具有框架的吸塑包装以及制造干粉药物容纳系统的相关方法公开(公告)号：US20050109659A1
公开(公告)日：2005-05-26
申请号：US10970549
申请日：2004-10-21
申请人： Anthony Hickey , Timothy Crowder , Jeffrey Warden , Keith Johnson , Mark Ketner , Jay Fording , Michael Garten , William Riley , Sean Anderson , Bruce Ferris , Paul Rockwell
发明人： Anthony Hickey , Timothy Crowder , Jeffrey Warden , Keith Johnson , Mark Ketner , Jay Fording , Michael Garten , William Riley , Sean Anderson , Bruce Ferris , Paul Rockwell
CPC分类号： B65D75/327 , A61M15/001 , A61M15/0045 , A61M15/0048 , A61M2202/064 , B65D83/06
摘要： Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.
摘要翻译： 干粉泡罩包装包括具有压电有源层的密封泡罩，其弯曲以使泡沫中的干粉振动以促进主动分散。
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3.发明授权Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances 有权干粉吸入器，相关的吸塑包装分选和打开机构，以及分配干粉物质的相关方法公开(公告)号：US07451761B2
公开(公告)日：2008-11-18
申请号：US10970154
申请日：2004-10-21
申请人： Anthony James Hickey , Timothy Crowder , Jeffrey Alan Warden , Keith Arthur Johnson , Mark Ennis Ketner , Jay Kinsley Fording , Michael Duane Garten , William Myles Riley , Sean Derek Anderson , Bruce Seymour Ferris , Paul Gilbert Rockwell
发明人： Anthony James Hickey , Timothy Crowder , Jeffrey Alan Warden , Keith Arthur Johnson , Mark Ennis Ketner , Jay Kinsley Fording , Michael Duane Garten , William Myles Riley , Sean Derek Anderson , Bruce Seymour Ferris , Paul Gilbert Rockwell
CPC分类号： A61M15/0045 , A61M15/001 , A61M15/0023 , A61M15/0038 , A61M15/0048 , A61M15/0078 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/0085 , A61M2202/064 , A61M2205/18 , A61M2205/43 , A61M2205/44 , A61M2205/581 , A61M2205/584
摘要： Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.
摘要翻译： 具有用于分配可吸入干粉的药物级制剂的多剂量干粉末包装的干粉吸入器包括：（a）泡罩包装，其上包括多个间隔开的密封泡罩，每个泡罩具有突出的天花板和限定 泡罩通道在其间，其中包含干粉; （b）在其前部保持叶片的可动刀片盒; 和（c）连接到可动刀片盒的可延伸的接口。 在操作中，用户向外拉出接口管，然后将吸嘴向内拉，以使吸塑包装前进，以将泡罩定位在吸入器中选定的分配位置，并使刀片盒将刀片移动穿过保持在 吸入器中的分配位置，从而打开保持在分配位置的泡罩。
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4.发明授权Blister packages with frames and associated methods of fabricating dry powder drug containment systems 有权具有框架的吸塑包装以及制造干粉药物容纳系统的相关方法公开(公告)号：US07377277B2
公开(公告)日：2008-05-27
申请号：US10970549
申请日：2004-10-21
申请人： Anthony James Hickey , Timothy Crowder , Jeffrey Alan Warden , Keith Arthur Johnson , Mark Ennis Ketner , Jay Kinsley Fording , Michael Duane Garten , William Myles Riley , Sean Derek Anderson , Bruce Seymour Ferris , Paul Gilbert Rockwell
发明人： Anthony James Hickey , Timothy Crowder , Jeffrey Alan Warden , Keith Arthur Johnson , Mark Ennis Ketner , Jay Kinsley Fording , Michael Duane Garten , William Myles Riley , Sean Derek Anderson , Bruce Seymour Ferris , Paul Gilbert Rockwell
CPC分类号： B65D75/327 , A61M15/001 , A61M15/0045 , A61M15/0048 , A61M2202/064 , B65D83/06
摘要： Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.
摘要翻译： 干粉泡罩包装包括具有压电有源层的密封泡罩，其弯曲以使泡沫中的干粉振动以促进主动分散。
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公开(公告)号：US20080197044A1
公开(公告)日：2008-08-21
申请号：US12109594
申请日：2008-04-25
申请人： Anthony James Hickey , Timothy Crowder , Jeffrey Alan Warden , Keith Arthur Johnson , Mark Ennis Ketner , Jay Kinsley Fording , Michael Duane Garten , William Myles Riley , Sean Derek Anderson , Bruce Seymour Ferris , Paul Gilbert Rockwell
发明人： Anthony James Hickey , Timothy Crowder , Jeffrey Alan Warden , Keith Arthur Johnson , Mark Ennis Ketner , Jay Kinsley Fording , Michael Duane Garten , William Myles Riley , Sean Derek Anderson , Bruce Seymour Ferris , Paul Gilbert Rockwell
IPC分类号： B65D83/04
CPC分类号： B65D75/327 , A61M15/001 , A61M15/0045 , A61M15/0048 , A61M2202/064 , B65D83/06
摘要： Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.
摘要翻译： 干粉泡罩包装包括具有压电有源层的密封泡罩，其弯曲以使泡沫中的干粉振动以促进主动分散。
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6.发明申请Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 有权干粉吸入器，相关的泡罩装置以及分配干粉物质的相关方法和制造吸塑包装公开(公告)号：US20050126569A1
公开(公告)日：2005-06-16
申请号：US11043363
申请日：2005-01-26
申请人： Timothy Crowder , Anthony Hickey , Jeffrey Warden
发明人： Timothy Crowder , Anthony Hickey , Jeffrey Warden
CPC分类号： B65D88/66 , A61M15/0003 , A61M15/0005 , A61M15/001 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0065 , A61M15/0075 , A61M2202/064 , A61M2205/18 , A61M2205/35 , A61M2205/52 , A61M2205/8206 , B65B37/04 , B65G53/66
摘要： The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.
摘要翻译： 本发明包括用于分配和/或保持吸入剂配制干粉物质的干粉吸入器以及相关的制造和分配方法，其可采用包括多个叠加频率的调幅非线性信号，该频率对应于先验流特征频率 的干粉被分配。 本发明还包括具有弹性柔性枢转盖的口袋式吸入器。
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公开(公告)号：US20050267628A1
公开(公告)日：2005-12-01
申请号：US11179163
申请日：2005-07-12
申请人： Timothy Crowder , Anthony Hickey
发明人： Timothy Crowder , Anthony Hickey
IPC分类号： B65B1/08 , A61M13/00 , A61M15/00 , B65B37/04 , B65D88/66 , B65G53/40 , B65G53/66 , G01F11/00
CPC分类号： B65D88/66 , A61M15/0003 , A61M15/0005 , A61M15/001 , A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0065 , A61M15/0068 , A61M15/0075 , A61M2202/064 , A61M2205/18 , A61M2205/35 , A61M2205/52 , A61M2205/8206 , B65B37/04 , B65G53/66
摘要： Systems for flowably dispensing dry powders include means for generating a first non-linear vibration input signal, the first non-linear input signal comprising a carrier frequency modulated by a plurality of different selected frequencies that correspond to a first dry powder formulation whereby first meted quantities of the first dry powder are serially dispensed to a receiving member. Related devices and computer program products for dispensing dry powders are also described.
摘要翻译： 用于流动分配干燥粉末的系统包括用于产生第一非线性振动输入信号的装置，第一非线性输入信号包括由对应于第一干粉配方的多个不同选定频率调制的载波频率， 的第一干粉末被顺序地分配到接收构件。 还描述了用于分配干粉的相关设备和计算机程序产品。
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8.发明申请BLISTER PACKAGES AND ASSOCIATED METHODS OF FABRICATING DRY POWDER DRUG CONTAINMENT SYSTEMS 审中-公开干燥粉末包装系统制造方法及相关方法公开(公告)号：US20070277820A1
公开(公告)日：2007-12-06
申请号：US10595478
申请日：2004-10-26
申请人： Timothy Crowder
发明人： Timothy Crowder
CPC分类号： A61M15/0045 , A61J1/035 , A61M15/0003 , A61M15/001 , A61M15/0026 , A61M15/0031 , A61M15/0048 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/6018
摘要： Dry powder blister packages include sealed blisters that incorporate or cooperate with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.
摘要翻译： 干粉泡罩包装包括密封的泡罩，其包含或配合压电有源层，该压电有源层弯曲以使泡沫中的干粉振动以促进主动分散。
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9.发明申请Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods 审中-公开干粉吸入装置，多剂量干粉药物包装，控制系统及相关方法公开(公告)号：US20060191534A1
公开(公告)日：2006-08-31
申请号：US11294681
申请日：2005-12-05
申请人： Anthony Hickey , Timothy Crowder
发明人： Anthony Hickey , Timothy Crowder
CPC分类号： A61M15/0085 , A61M15/0048 , A61M15/0051 , A61M2016/0021 , A61M2202/064 , A61M2205/50
摘要： Dry powder inhalers with integrated active energy patient assist dispersal systems are configured with control systems which provide adjustable energy output responsive to the user's inspiratory capabilities and/or the flowability of the dry powder drug being administered. The multi-dose dry drug package includes a piezoelectric polymer substrate (such as PVDF) which flexes to deform and provide mechanical oscillation in a selected region of the package corresponding to the dry powder drug dose in the exit flow path and is thus actively dispersed into the exit flow path of the inhaler during the user's inspiratory activity. Control systems employ fuzzy logic models of the flowability of particular drug formulations (also being able to compensate or allow for the particular type of excipient used) and/or adjust for the real-time measured inspiratory efforts of the user. Manufacturing process control systems can adjust certain parameters in response to a fuzzy logic model of the flowability of the dry powder and other conditions associated with the dry powder drug being produced and/or dispensed.
摘要翻译： 具有集成的活跃能量患者辅助分散系统的干粉吸入器配置有控制系统，其响应于使用者的吸入能力和/或所施用的干粉药物的流动性而提供可调节的能量输出。 多剂量干药包包括压电聚合物基材（例如PVDF），该压电聚合物基体在与出口流动路径中的干粉药物剂量相对应的包装的选定区域中弯曲变形并提供机械振荡，因此主动分散于 用户吸气活动期间吸入器的出口流动路径。 控制系统使用特定药物制剂的流动性的模糊逻辑模型（也能够补偿或允许所使用的特定类型的赋形剂）和/或调节用户实时测量的吸气努力。 制造过程控制系统可以响应于干粉流动性的模糊逻辑模型和与所生产和/或分配的干粉药物相关的其它条件来调节某些参数。
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