摘要:
Compounds of Formula I, wherein R1—R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer's Disease and Down's syndrome are also described.
摘要:
A toy comprises a three-dimensional body that can be compressed to actuate a squeaker chamber to move air through a squeaker device. The squeaker chamber is formed by an elongated resilient member in the toy body that can be actuated to operate the squeaker device from a location on the toy distal from the squeaker device. In one embodiment, the resilient member is one or more elastic bladders and in another embodiment the resilient member is one or more resilient tubes. The squeaker chamber may be of various configurations for a variety of toy shapes.
摘要:
The present invention relates to Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.
摘要:
A dog harness is comprised of a torso strap encircling a dog's chest, connected to a chest strap passing around the chest of a dog, and a shoulder strap passing over the back of a dog. The chest strap is provided with a limited slip loop. A leash connector is fixed to the limited slip loop. When a leash is attached to the leash connector, a directional pull on the leash causes the leash connector to slide in the direction of the pull, pulling the limited slip loop to the side and moving the pull off the center of the dog's chest, thus decreasing the opposition reflex.
摘要:
A non-consumable pet toy (100) includes a resilient first concave-shaped molded member (102) having a first peripheral edge (130) and a resilient second concave-shaped molded member (104) having a second peripheral edge (132). The first and second members have a treat-retaining cavity (101) between them. The treat retaining pet toy also includes a fastener (110, 112) extending centrally through the treat-retaining cavity. The fastener fastens the first member to the second member such that the first peripheral edge is at a predetermined distance from the second peripheral edge.
摘要:
A non-consumable pet toy includes a body having a first treat-retaining cavity and a first opening that extends between the first treat-retaining cavity and an outer surface of the body. The non-consumable pet toy also includes a metering device in the first opening that dispenses treats from the first treat-retaining cavity through the first opening at a metered rate. The first treat-retaining cavity being refillable through the metering device.
摘要:
The device includes a source of laser radiation for emitting a beam of planar and thin section in a sector having an angle of divergence adapted to the possibilities of displacement of the moving body, in a plane parallel to the plane of displacement of the moving body. A camera is reponsive to the reflection of the laser radiation from, for example, a point on the front set of wheels of an aircraft. A calculating device responsive to data received from the camera determines the distance and the azimuth of this point relative to a fixed reference, and a display device controlled by the calculating device informs the operator or the pilot of the position of the moving body.