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13 条记录 (耗时 0.037 秒)

    Caspase-3 Substrate Comprising Imaging Agents
    5.
    发明申请
    Caspase-3 Substrate Comprising Imaging Agents 审中-公开
    包含成像剂的胱天蛋白酶-3底物

    公开(公告)号：US20080286201A1

    公开(公告)日：2008-11-20

    申请号：US11815360

    申请日：2006-02-03

    申请人： Benedicte Guilbert ,  Sue Champion ,  Alexander Mark Gibson ,  Sally-Anne Ricketts ,  Michelle Avory ,  Bente E. Arbo

    发明人： Benedicte Guilbert ,  Sue Champion ,  Alexander Mark Gibson ,  Sally-Anne Ricketts ,  Michelle Avory ,  Bente E. Arbo

    IPC分类号： A61K51/08 ,  C12N9/50

    CPC分类号： A61K51/088 ,  A61K38/07

    摘要： The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 substrate peptide labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides radiopharmaceutical compositions comprising the imaging agents, together with kits for the preparation of the radiopharmaceuticals. Also described are non-radioactive precursors suitable for the preparation of the imaging agents. The imaging agents are useful for the diagnostic imaging and or therapy monitoring in vivo of various disease states where caspase-3 is involved.

    摘要翻译： 本发明涉及用于体内成像的诊断成像剂。 成像剂包括用适于体内诊断成像的成像部分标记的合成半胱天冬酶-3底物肽。 本发明还提供包含成像剂的放射性药物组合物，以及用于制备放射性药物的试剂盒。 还描述了适用于制备显像剂的非放射性前体。 成像剂可用于在体内涉及caspase-3的各种疾病状态的诊断成像和/或治疗监测。

    Imaging agents comprising barbituric acid derivatives
    6.
    发明申请
    Imaging agents comprising barbituric acid derivatives 审中-公开
    包含巴比妥酸衍生物的成像剂

    公开(公告)号：US20060120956A1

    公开(公告)日：2006-06-08

    申请号：US10530836

    申请日：2003-10-08

    申请人： Klaus Kopka ,  Hans-Jorg Breyholz ,  Stefan Wagner ,  Michael Shafers ,  Bodo Leykau ,  Benedicte Guilbert ,  Duncan Wynn

    发明人： Klaus Kopka ,  Hans-Jorg Breyholz ,  Stefan Wagner ,  Michael Shafers ,  Bodo Leykau ,  Benedicte Guilbert ,  Duncan Wynn

    IPC分类号： A61K51/00 ,  C07F5/00 ,  C07D403/02 ,  C07K16/46

    CPC分类号： A61K51/0497 ,  A61K49/0438 ,  A61K51/0459

    摘要： The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic barbituric acid derivative labelled at the 5-position with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging agents, together with kits of the preparation of the radiopharmaceuticals. Also described are chelator conjugates of the barbituric acid derivative, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the diagnostic imaging in vivo of various disease states, including atherosclerosis.

    摘要翻译： 本发明涉及用于体内成像的诊断成像剂。 成像剂包括在5位标记的合成巴比妥酸衍生物，其具有适于体内诊断成像的成像部分。 本发明还提供包含成像剂的药物和放射性药物组合物，以及放射性药物的制备试剂盒。 还描述了适用于制备包含放射性或顺磁金属离子的成像剂的巴比妥酸衍生物的螯合剂缀合物。 成像剂可用于各种疾病状态的体内诊断成像，包括动脉粥样硬化。

    Novel imaging agents
    9.
    发明申请
    Novel imaging agents 审中-公开
    新型成像剂

    公开(公告)号：US20060275215A1

    公开(公告)日：2006-12-07

    申请号：US10560509

    申请日：2004-11-26

    申请人： Duncan Hiscock ,  Ben Newton ,  Benedicte Guilbert

    发明人： Duncan Hiscock ,  Ben Newton ,  Benedicte Guilbert

    IPC分类号： A61K51/00 ,  C12N9/99 ,  A61K49/10 ,  A61K49/00

    CPC分类号： A61K51/0455 ,  A61K51/0431 ,  A61K51/0446 ,  A61K51/0459 ,  A61K51/088 ,  Y02P20/582

    摘要： The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 inhibitor labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging agents, together with kits for the preparation of the radiopharmaceuticals. Also described are chelator conjugates of the caspase-3 inhibitor, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the diagnostic imaging and or therapy monitoring in vivo of various disease states where caspase-3 is involved.

    摘要翻译： 本发明涉及用于体内成像的诊断成像剂。 成像剂包括用适于体内诊断成像的成像部分标记的合成半胱天冬酶-3抑制剂。 本发明还提供包含成像剂的药物和放射性药物组合物，以及用于制备放射性药物的试剂盒。 还描述了胱天蛋白酶-3抑制剂的螯合剂缀合物，其适用于制备包含放射性或顺磁性金属离子的成像剂。 成像剂可用于在体内涉及caspase-3的各种疾病状态的诊断成像和/或治疗监测。

    Novel Imaging Agents for Fibrosis
    10.
    发明申请
    Novel Imaging Agents for Fibrosis 审中-公开
    用于纤维化的新型成像剂

    公开(公告)号：US20080279765A1

    公开(公告)日：2008-11-13

    申请号：US12095931

    申请日：2006-12-07

    申请人： Salah Chettibi ,  Ben Newton ,  Benedicte Guilbert ,  Helge Tolleshaug ,  Magne Solbakken

    发明人： Salah Chettibi ,  Ben Newton ,  Benedicte Guilbert ,  Helge Tolleshaug ,  Magne Solbakken

    IPC分类号： A61K51/00 ,  C07K14/47 ,  C07H13/00 ,  C07K14/00 ,  C07C403/08 ,  C07K7/06 ,  C07K5/08 ,  C07F13/00 ,  A61K49/00

    CPC分类号： A61K51/08 ,  A61K51/0402 ,  A61K51/088

    摘要： The present invention provides a novel imaging agent targeting the mannose-6-phosphate (M6P) receptor suitable for the non-invasive visualization of fibrosis. A method for the preparation of the imaging agent is also provided by the invention, as well as a precursor for use in said method. The invention also provides a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition in which the mannose-6-phosphate receptor is upregulated is provided.

    摘要翻译： 本发明提供了靶向适于非侵入性可视化纤维化的甘露糖-6-磷酸（M6P）受体的新型成像剂。 本发明还提供了用于制备显影剂的方法，以及用于所述方法的前体。 本发明还提供一种药物组合物，其包含该成像剂和用于制备药物组合物的试剂盒。 在另一方面，提供了用于体内成像和用于诊断其中甘露糖-6-磷酸受体上调的病症的药物的制备的成像剂的用途。