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    Compositions and methods for inhibiting expression of the HAMP gene
    5.
    发明授权
    Compositions and methods for inhibiting expression of the HAMP gene 有权
    用于抑制HAMP基因表达的组合物和方法

    公开(公告)号：US08268799B2

    公开(公告)日：2012-09-18

    申请号：US13184087

    申请日：2011-07-15

    申请人： Tomoko Nakayama ,  Anke Geick ,  Pamela Tan ,  Herbert Y. Lin

    发明人： Tomoko Nakayama ,  Anke Geick ,  Pamela Tan ,  Herbert Y. Lin

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/1136 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2320/11 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the HAMP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HAMP gene expression and the expression of the HAMP gene using the pharmaceutical composition.

    摘要翻译： 本发明涉及用于抑制HAMP基因（HAMP基因）表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸 ，并且其与至少一部分HAMP基因基本上互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由HAMP基因表达引起的疾病和使用该药物组合物的HAMP基因表达的方法。

    Compositions and Methods for Inhibiting Expression of Eg5 Gene
    6.
    发明申请
    Compositions and Methods for Inhibiting Expression of Eg5 Gene 审中-公开
    抑制Eg5基因表达的组成和方法

    公开(公告)号：US20120136145A1

    公开(公告)日：2012-05-31

    申请号：US13165568

    申请日：2011-06-21

    申请人： David Bumcrot ,  Pamela Tan ,  Hans-Peter Vornlocher ,  Anke Geick

    发明人： David Bumcrot ,  Pamela Tan ,  Hans-Peter Vornlocher ,  Anke Geick

    IPC分类号： C07H21/02

    CPC分类号： C12N15/1138 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3233 ,  C12N2310/3515 ,  C12N2330/30 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the Eg5 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Eg5 expression and the expression of the Eg5 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Eg5 gene in a cell.

    摘要翻译： 本发明涉及用于抑制Eg5基因（Eg5基因）表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸 ，并且其与Eg5基因的至少一部分基本上互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由Eg5表达引起的疾病和使用该药物组合物表达Eg5基因的方法; 以及用于抑制细胞中Eg5基因表达的方法。