公开(公告)号：US08227188B2

公开(公告)日：2012-07-24

申请号：US12875695

申请日：2010-09-03

申请人： Antonin de Fougerolles ,  Tatiana Novobrantseva ,  Pamela Tan ,  Anke Geicke ,  Rachel Meyers

发明人： Antonin de Fougerolles ,  Tatiana Novobrantseva ,  Pamela Tan ,  Anke Geicke ,  Rachel Meyers

IPC分类号： C12Q1/68

CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/331 ,  C12N2760/16111

摘要： The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.

摘要翻译： 本发明涉及调节流感病毒基因表达的组合物和方法，更具体地涉及通过化学修饰的寡核苷酸下调流感病毒基因。

公开(公告)号：US20110033859A1

公开(公告)日：2011-02-10

申请号：US12875695

申请日：2010-09-03

申请人： Antonin de Fougerolles ,  Tatiana Novobrantseva ,  Pamela Tan ,  Anke Geick ,  Rachel Meyers

发明人： Antonin de Fougerolles ,  Tatiana Novobrantseva ,  Pamela Tan ,  Anke Geick ,  Rachel Meyers

IPC分类号： C12Q1/68

CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/331 ,  C12N2760/16111

摘要： The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.

摘要翻译： 本发明涉及调节流感病毒基因表达的组合物和方法，更具体地涉及通过化学修饰的寡核苷酸下调流感病毒基因。

公开(公告)号：US20070197460A1

公开(公告)日：2007-08-23

申请号：US11555555

申请日：2006-11-01

申请人： Antonin Fougerolles ,  Tatiana Novobrantseva ,  Pamela Tan ,  Anke Geick ,  Rachel Meyers

发明人： Antonin Fougerolles ,  Tatiana Novobrantseva ,  Pamela Tan ,  Anke Geick ,  Rachel Meyers

IPC分类号： A61K48/00 ,  C12Q1/70 ,  C12N15/86

CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/331 ,  C12N2760/16111

摘要： The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.

摘要翻译： 本发明涉及调节流感病毒基因表达的组合物和方法，更具体地涉及通过化学修饰的寡核苷酸下调流感病毒基因。

公开(公告)号：US08410073B2

公开(公告)日：2013-04-02

申请号：US13359421

申请日：2012-01-26

申请人： Akshay Vaishnaw ,  Saraswathy V. Nochur ,  Sayda Elbashir ,  Muthiah Manoharan ,  Rachel Meyers

发明人： Akshay Vaishnaw ,  Saraswathy V. Nochur ,  Sayda Elbashir ,  Muthiah Manoharan ,  Rachel Meyers

IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12N15/1131 ,  A61K31/708 ,  A61K31/713 ,  A61M11/00 ,  C12N2310/14

摘要： Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA comprises a sense strand of ALN-RSV01 and an antisense strand of ALN-RSV01.

摘要翻译： 提供了用于预防或治疗人体RSV感染的方法和组合物。 所述方法包括施用一种或多种剂量的包含siRNA的组合物。 剂量可以配制用于局部或肠胃外给药。 局部给药包括作为鼻喷雾给药，或通过吸入可吸入颗粒或液滴。 siRNA包含ALN-RSV01的有义链和ALN-RSV01的反义链。

公开(公告)号：US08263572B2

公开(公告)日：2012-09-11

申请号：US13160268

申请日：2011-06-14

申请人： Rachel Meyers

发明人： Rachel Meyers

IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12N15/1131 ,  A61K9/0078 ,  A61K31/713 ,  A61M11/06 ,  A61M15/00 ,  A61M16/14 ,  A61M2202/04 ,  A61M2202/064 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32

摘要： The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.

摘要翻译： 本发明基于体内证据，可以通过鼻内施用iRNA试剂以及通过肠胃外给药这种试剂来抑制RSV。 此外，显示可以同时治疗多于一种的病毒来实现有效的病毒降低。 基于这些发现，本发明提供了可用于减少受试者例如哺乳动物（例如人）中的RSV mRNA水平，RSV蛋白水平和病毒滴度的一般和特定组合物和方法。 这些发现可以应用于其他呼吸道病毒。

公开(公告)号：US20080027147A1

公开(公告)日：2008-01-31

申请号：US11786411

申请日：2007-04-11

申请人： Rachel Meyers ,  Mark Williamson ,  Kevin Leiby ,  Rosana Kepeller-Libermann ,  Peter Olandt ,  Kyle MacBeth ,  Laura Rodolph-Owen ,  Fong-Ying Tsai ,  John Hunter

发明人： Rachel Meyers ,  Mark Williamson ,  Kevin Leiby ,  Rosana Kepeller-Libermann ,  Peter Olandt ,  Kyle MacBeth ,  Laura Rodolph-Owen ,  Fong-Ying Tsai ,  John Hunter

IPC分类号： A61K47/00 ,  A61P43/00 ,  C07H21/04 ,  C07K16/40 ,  C12N15/00 ,  C12N5/06 ,  C12N9/00 ,  C12N9/99 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/566

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1007 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1096 ,  C12N9/93 ,  C12Q1/48 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y602/01001 ,  C12Y602/01016

摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。 本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。 本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US20070178515A1

公开(公告)日：2007-08-02

申请号：US11726163

申请日：2007-03-21

申请人： Rachel Meyers ,  John Hunter

发明人： Rachel Meyers ,  John Hunter

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

CPC分类号： C12N9/1205 ,  C12Q1/48 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The invention provides isolated nucleic acids molecules, designated 3714, 16742, 23546, or 13887 nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 3714, 16742, 23546, or 13887 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 3714, 16742, 23546, or 13887 gene has been introduced or disrupted. The invention still further provides isolated 3714, 16742, 23546, or 13887 proteins, fusion proteins, antigenic peptides and anti-3714, -16742, -23546, or -13887 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的蛋白激酶的分离的核酸分子，命名为3714,16742,23546或13887核酸分子。 本发明还提供反义核酸分子，含有3714,16742,23546或13887核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中3714,16742,23546或 13887基因已被引入或破坏。 本发明还进一步提供分离的3714,16742,23546或13887蛋白，融合蛋白，抗原肽和抗-3714，-16742，-23546或-13887抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US07214502B2

公开(公告)日：2007-05-08

申请号：US10393316

申请日：2003-03-20

申请人： Rachel Meyers ,  John Joseph Hunter

发明人： Rachel Meyers ,  John Joseph Hunter

IPC分类号： C12Q1/48 ,  C12N9/12

CPC分类号： C12N9/1205 ,  C12Q1/48 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The invention provides isolated nucleic acids molecules, designated 3714, 16742, 23546, or 13887 nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 3714, 16742, 23546, or 13887 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 3714, 16742, 23546, or 13887 gene has been introduced or disrupted. The invention sill further provides isolated 3714, 16742, 23546, or 13887 proteins, fusion proteins, antigenic peptides and anti-3714, -16742, -23546, or -13887 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的蛋白激酶的分离的核酸分子，命名为3714,16742,23546或13887核酸分子。 本发明还提供反义核酸分子，含有3714,16742,23546或13887核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中3714,16742,23546或 13887基因已被引入或破坏。 本发明进一步提供分离的3714,16742,23546或13887蛋白，融合蛋白，抗原肽和抗-3714，-16742，-23546或-13887抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20070065848A1

公开(公告)日：2007-03-22

申请号：US11493347

申请日：2006-07-26

申请人： Rachel Meyers ,  Kyle MacBeth ,  Rory Curtis ,  Laura Rudolph-Owen ,  Nadine Weich ,  Peter Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph Carroll

发明人： Rachel Meyers ,  Kyle MacBeth ,  Rory Curtis ,  Laura Rudolph-Owen ,  Nadine Weich ,  Peter Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph Carroll

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C12N9/001 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1048 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/48 ,  C12N9/80 ,  C12N2799/021 ,  C12Q1/32 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2500/10 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。 本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。 本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20070037203A1

公开(公告)日：2007-02-15

申请号：US11583766

申请日：2006-10-19

申请人： Rosana Kapeller-Libermann ,  John Hunter ,  Rachel Meyers ,  Laura Rudolph-Owen ,  Rory Curtis ,  Peter Olandt ,  Fong-Ying Tsai ,  Katherine Galvin ,  Miyoung Chun ,  Mark Williamson ,  Inmaculada Silos-Santiago ,  Rajasekhar Bandaru

发明人： Rosana Kapeller-Libermann ,  John Hunter ,  Rachel Meyers ,  Laura Rudolph-Owen ,  Rory Curtis ,  Peter Olandt ,  Fong-Ying Tsai ,  Katherine Galvin ,  Miyoung Chun ,  Mark Williamson ,  Inmaculada Silos-Santiago ,  Rajasekhar Bandaru

IPC分类号： C12Q1/68 ,  C07H21/04 ,  A61K48/00 ,  C07K14/705

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C12N9/1235

摘要： The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 gene has been introduced or disrupted. The invention still further provides isolated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 proteins, fusion proteins, antigenic peptides and anti-21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为21910,5663,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555和593核酸 分子。 本发明还提供反义核酸分子，含有21910,5663,55053,2504,15977,14760,25501,17903,3700,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,3855的重组表达载体 和593个核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中21910,5663,5553,2504,15977,14760,25501,17903,3720,21529,26176， 已经引入或破坏了18610,33217,21967，h1983，m1983,38555或593基因。 本发明还进一步提供分离的21910,5563,4560,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555或593蛋白，融合蛋白， 抗原肽和抗-19910,563634,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,56638,18610,33217,21967，h1983，m1983,38555或593抗体。 还提供了利用本发明组合物的诊断和治疗方法。