公开(公告)号：US12017195B2

公开(公告)日：2024-06-25

申请号：US17257816

申请日：2019-07-01

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Quan Qing ,  Ching-wei Tsao ,  Peiming Zhang

IPC: B01J19/00 ,  C07K1/04

CPC classification number: B01J19/0093 ,  B01J19/0046 ,  C07K1/045 ,  B01J2219/00317 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00822 ,  B01J2219/00853 ,  B01J2219/00855

Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising atop surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.

公开(公告)号：US20210291137A1

公开(公告)日：2021-09-23

申请号：US17257816

申请日：2019-07-01

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Quan Qing ,  Ching-wei Tsao ,  Peiming Zhang

IPC: B01J19/00 ,  C07K1/04

Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising a top surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.

公开(公告)号：US12209986B2

公开(公告)日：2025-01-28

申请号：US18550881

申请日：2022-03-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Quan Qing

IPC: G01N27/327 ,  B01L3/00

Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.

公开(公告)号：US20230249174A1

公开(公告)日：2023-08-10

申请号：US18004663

申请日：2021-07-06

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Quan Qing

IPC: B01L3/00 ,  G01N21/65

CPC classification number: B01L3/5027 ,  G01N21/658 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/16

Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties.

公开(公告)号：US20210247347A1

公开(公告)日：2021-08-12

申请号：US17173569

申请日：2021-02-11

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stuart Lindsay ,  Joshua Sadar ,  Quan Qing

IPC: G01N27/327 ,  G01N27/02

Abstract: The present disclosure provides devices, systems, and methods related to protein bioelectronics. In particular, the present disclosure provides bioelectronic devices, systems, and methods that utilize a defined electrical potential to maximize electrical conductance of a protein-of-interest, which can serve as a basis for the fabrication of enhanced bioelectronic devices for the direct measurement of protein activity.

公开(公告)号：US12241857B2

公开(公告)日：2025-03-04

申请号：US18550881

申请日：2022-03-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Quan Qing

IPC: G01N27/327 ,  B01L3/00

Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.

公开(公告)号：US11634702B2

公开(公告)日：2023-04-25

申请号：US16675127

申请日：2019-11-05

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Quan Qing ,  John Albeck ,  Liang Guo ,  Min Zhao ,  Houpu Li

IPC: C12N13/00

Abstract: A method for activating a cell-signaling pathway of interest in a cell, including applying a time-modulated localized alternating current electrical field to the cell, wherein the amplitude and frequency of the localized alternating current electrical field is selected to activate the cell signaling pathway of interest, thereby activating the cell signaling pathway.