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公开(公告)号：US12017195B2
公开(公告)日：2024-06-25
申请号：US17257816
申请日：2019-07-01
Inventor： Quan Qing , Ching-wei Tsao , Peiming Zhang
CPC classification number: B01J19/0093 , B01J19/0046 , C07K1/045 , B01J2219/00317 , B01J2219/00529 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , B01J2219/00822 , B01J2219/00853 , B01J2219/00855
Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising atop surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.
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公开(公告)号：US20200333321A1
公开(公告)日：2020-10-22
申请号：US16917474
申请日：2020-06-30
Inventor： Stuart Lindsay , Peiming Zhang , Yanan Zhao
IPC: G01N33/487
Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.
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公开(公告)号：US10267785B2
公开(公告)日：2019-04-23
申请号：US15922436
申请日：2018-03-15
Inventor： Stuart Lindsay , Peiming Zhang
IPC: G01N33/68 , G01N33/543 , G01N33/487 , G01N27/447 , G01N27/26 , G01N15/12 , C12Q1/37
Abstract: Embodiments of the present disclosure are directed to methods, systems and devices, for analyzing the molecules. For example, in some embodiments, a system is provided which includes a first volume of conducting fluid, a second volume of conducting fluid, an orifice in communication with the first and second volumes of fluid, and means for applying an electric potential difference between the first and second volumes of fluid. In some such embodiments, a conjugate product is provided which includes charged polymers each having attached thereto at least one first molecule for analysis, where the product carries a predetermined charge greater than the charge on the first molecule, and upon dissolving the product in the first volume of fluid, the product is directed into the orifice.
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公开(公告)号：US09810681B2
公开(公告)日：2017-11-07
申请号：US14851933
申请日：2015-09-11
Inventor： Stuart Lindsay , Shuai Chang , Jin He , Peiming Zhang , Shuo Huang
IPC: G01N27/00 , G01N33/487 , C12Q1/68 , G01N27/327
CPC classification number: G01N33/48721 , C12Q1/6869 , G01N27/3275 , Y10T436/143333
Abstract: The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
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公开(公告)号：US20210291137A1
公开(公告)日：2021-09-23
申请号：US17257816
申请日：2019-07-01
Inventor： Quan Qing , Ching-wei Tsao , Peiming Zhang
Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising a top surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20190256616A1
公开(公告)日：2019-08-22
申请号：US16155972
申请日：2018-10-10
Inventor： Peiming Zhang , Xu Wang , Jong One Im , Stuart Lindsay
Abstract: The present disclosure provides a method for identifying and quantifying sulfated glycosaminoglycans, including for example heparin, by passing a sample through nanopores. The glycosaminoglycans sample is measured in microliter quantities, at nanomolar concentrations with detection of impurities below 0.5%, and a dynamic range over five decades of magnitude with a trained machine learning algorithm.
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公开(公告)号：US10330632B2
公开(公告)日：2019-06-25
申请号：US15203383
申请日：2016-07-06
Inventor： Stuart Lindsay , Peiming Zhang
IPC: G01N33/487 , C12Q1/68 , G01N27/327 , C12Q1/6869 , G01N27/02
Abstract: An system for recognition of a translocating polymeric target molecule includes a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. A pair of spaced apart sensing electrodes border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. Each affinity element may connected to its corresponding electrode via one or more intermediary compounds, such as a linker molecule and/or an electrode attachment molecule. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. During translocation, the electrodes affinity elements and first and second portions of the target molecule complete an electrical circuit and allow a measurable electrical current to pass between the first and second electrodes. The time-varying nature of this electrical current, and the specific affinity elements employed, allow one to characterize the target molecule.
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8.发明授权公开(公告)号：US10145846B2
公开(公告)日：2018-12-04
申请号：US15303960
申请日：2015-04-16
Inventor： Stuart Lindsay , Peiming Zhang , Pei Pang
IPC: G01N33/543 , B01L3/00 , G01N33/487
Abstract: A sensing device is provided that includes a tunnel junction created by forming a hole in a layered tunnel junction (for example). A chemically, well-defined surface may be formed by coupling affinity reagents to the electrodes, which, by these means, the surface may be configured to be selective for a particular analyte.
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公开(公告)号：US20160280723A1
公开(公告)日：2016-09-29
申请号：US15033004
申请日：2014-10-28
Inventor： Peiming Zhang , Subhadip Senapati , Saikat Manna
IPC: C07F7/18 , C07C317/28 , G01Q70/18 , C12N15/115 , C07K5/12 , C07F7/04 , C07C315/00
CPC classification number: C07F7/1804 , C07C315/00 , C07C317/28 , C07F7/045 , C07F7/10 , C07F7/1876 , C07K5/126 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2310/3517 , G01Q60/42 , G01Q70/18
Abstract: Chemical linkage reagents, methods of making and method of using the same are provided. Chemical linkage reagents according to at least some of the embodiments of the present disclosure may be incorporated into or operatively-linked with affinity molecules for attachment to silicon oxide surfaces to, for example, measure interactions between an affinity molecule and its targeting biomolecules.
Abstract translation: 提供了化学键合试剂，制备方法及其使用方法。 根据本公开的至少一些实施方案的化学连接试剂可以并入或与活性连接的亲和分子连接到氧化硅表面以例如测量亲和分子与其靶向生物分子之间的相互作用。
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公开(公告)号：US11630098B2
公开(公告)日：2023-04-18
申请号：US16917474
申请日：2020-06-30
Inventor： Stuart Lindsay , Peiming Zhang , Yanan Zhao
IPC: G01N33/487
Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.
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