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公开(公告)号：US20180002709A1
公开(公告)日：2018-01-04
申请号：US15545275
申请日：2016-01-22
Inventor： Sidney HECHT , Larisa (Liza) DEDKOVA , Rumit MAINI , Sandipan ROY CHOWDHURY , Rakesh PAUL
IPC: C12N15/67 , C12N9/06 , C07D277/593 , C12N15/11 , C07D263/34
Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
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公开(公告)号：US20220333216A1
公开(公告)日：2022-10-20
申请号：US17616341
申请日：2020-06-03
Inventor： Sidney HECHT , Jesse WAGGONER , Mingxuan GAO , Shengxi CHEN
IPC: C12Q1/70 , C12Q1/6818
Abstract: Described herein are systems and methods that may be used to differentially detect viral serotype specific nucleic acid. For example, these systems may comprise multiple DNA-nanostructures, capture oligonucleotides and protector oligonucleotides, wherein each DNA-nanostructure and its associated capture oligonucleotide and protector oligonucleotide are specific for a unique viral type or serotype.
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公开(公告)号：US20180065941A1
公开(公告)日：2018-03-08
申请号：US15550282
申请日：2016-02-17
Inventor： Sidney HECHT , Omar KHDOUR , Sandipan Roy CHOWDHURY , Indrajit BANDYOPADHYAY
IPC: C07D279/20 , C07D417/04 , C07D417/14
CPC classification number: C07D279/20 , C07D279/18 , C07D417/04 , C07D417/14
Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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公开(公告)号：US20230295101A1
公开(公告)日：2023-09-21
申请号：US18070993
申请日：2022-11-29
Inventor： Sidney HECHT , Omar KHDOUR , Sandipan Roy CHOWDHURY , Nishant P. VISAVADIYA
IPC: C07D279/18 , A61P39/06 , A61K31/5415 , C07D279/14 , A61P25/28 , A61P9/00 , A61P3/10 , A61P35/00
CPC classification number: C07D279/18 , A61P39/06 , A61K31/5415 , C07D279/14 , A61P25/28 , A61P9/00 , A61P3/10 , A61P35/00
Abstract: The invention provides compounds having the general formula I:
and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.-
公开(公告)号：US20220081404A1
公开(公告)日：2022-03-17
申请号：US17243005
申请日：2021-04-28
Inventor： Sidney HECHT , Omar KHDOUR , Sandipan Roy CHOWDHURY , Indrajit BANDYOPADHYAY
IPC: C07D279/20 , C07D279/18 , C07D417/04 , C07D417/14
Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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Patent Agency Ranking
公开(公告)号：US20210276979A1
公开(公告)日：2021-09-09
申请号：US16327287
申请日：2017-08-18
Inventor： Sidney HECHT , Omar KHDOUR , Arnaud CHEVALIER
IPC: C07D403/04 , C07D403/14 , C07D239/60 , A61P39/06
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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7.发明申请公开(公告)号：US20200247775A1
公开(公告)日：2020-08-06
申请号：US16784202
申请日：2020-02-06
Inventor： Arnaud CHEVALIER , Omar KHDOUR , Yanmin ZHANG , Sidney HECHT
IPC: C07D321/00 , C07D493/10 , C07D487/14 , C07D417/04 , C07D413/04 , C07D405/04 , C07D403/08 , C07D311/58 , C07D311/06
Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.
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公开(公告)号：US20190185441A1
公开(公告)日：2019-06-20
申请号：US16327284
申请日：2017-08-24
Inventor： Sidney HECHT , Omar KHDOUR , Sandipan Roy CHOWDHURY , Nishant P VISAVADIYA
CPC classification number: C07D279/18 , A61K31/5415 , A61P3/10 , A61P9/00 , A61P25/28 , A61P35/00 , A61P39/06 , C07D279/14
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20240409521A1
公开(公告)日：2024-12-12
申请号：US18691696
申请日：2021-09-14
Inventor： Omar KHDOUR , Sidney HECHT , Jun LIU , Indrajit BANDYOPADHYAY
IPC: C07D279/20 , A61K31/5415
Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 has any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as cytoprotective agents.
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公开(公告)号：US20220324841A1
公开(公告)日：2022-10-13
申请号：US17841288
申请日：2022-06-15
Inventor： Sidney HECHT , Omar KHDOUR , Arnaud CHEVALIER
IPC: C07D403/04 , A61P39/06 , C07D239/60 , C07D403/14
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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