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公开(公告)号：US20220001378A1
公开(公告)日：2022-01-06
申请号：US17293707
申请日：2019-12-05
申请人： Arizona Board of Regents on Behalf of the University of Arizona , The Trustees of Columbia University in the City of New York
发明人： Frederic ZENHAUSERN , Brett DUANE , Jian GU , Alan NORDQUIST , David BRENNER , Mikhail REPIN
IPC分类号： B01L3/00
摘要： Provided herein are methods and related devices for preprocessing a biological sample during transit. The method may comprise the steps of: storing a biological sample in a storage container having walls that defines a storage volume; transporting the storage container with the stored biological sample to a sample processing facility; controlling one or more storage container parameters during the transporting step to initiate preprocessing of the biological sample; wherein the controlling step improves a processing parameter at the sample processing facility.
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公开(公告)号：US20210030347A1
公开(公告)日：2021-02-04
申请号：US17044172
申请日：2019-04-26
发明人： Frederic ZENHAUSERN , Jian GU , Alan NORDQUIST
摘要： Provided is an integrated sample collection device for self-collection and analytical pre-processing of a fluid sample, such as a blood sample from a user. A housing is configured to be held by a user, such as a single hand of a user. A contact-activated penetrating member is disposed at least partially in the housing and configured to penetrate skin. A capillary tube is disposed at least partially in the housing and configured to collect blood released by the penetrating member that penetrates the skin. A vacuum-assisted blood collection container can be fluidically connected to the capillary tube for receiving at least a portion of the collected blood. One or more stabilizing/pre-processing agents are provided for stabilizing/pre-processing collected blood in the capillary tube, the vacuum-assisted blood storage container, or both.
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公开(公告)号：US20240344022A1
公开(公告)日：2024-10-17
申请号：US18294371
申请日：2022-08-01
发明人： Frederic ZENHAUSERN , Alan NORDQUIST , Baiju THOMAS , Matthew BARRETT , Jerome LACOMBE , Ashlee HARRIS
CPC分类号： C12N5/0062 , C12M25/14 , C12M35/04 , C12N2513/00 , C12N2533/90
摘要： Provided herein are stretch devices and related methods for controlled three-dimensional stretching of scaffolds supported on a stretchable substrate. A stretchable substrate is capable of receiving the three-dimensional scaffold, and a stretchable substrate holder is configured to connect to the stretchable substrate. An actuator is connected to the stretchable substrate holder to exert a cyclic stretch on the stretchable substrate and periodically stretch the three-dimensional scaffold connected to the stretchable substrate. A sample holder is configured to immerse the three-dimensional scaffold in a tissue culture media.
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公开(公告)号：US20240277322A1
公开(公告)日：2024-08-22
申请号：US18247596
申请日：2021-10-01
申请人： Arizona Board of Regents on Behalf of the University of Arizona , Wren Laboratories, LLC , Costa Devices Limited
发明人： Frederic ZENHAUSERN , Matthew BARRETT , Baiju THOMAS , Alan NORDQUIST , Jerome LACOMBE , Irvin MODLIN , Mark KIDD
IPC分类号： A61B10/00
CPC分类号： A61B10/0051
摘要： Provided herein are self-collection devices for collecting and/or processing biofluids. The biofluid, such as saliva, is collected in a collection tube. A tube insert in the collection tube is configured to work with a cap having an integrated reservoir volume holding a reagent. Upon connecting the cap to the collection tube, the material in the reservoir volume is effectively introduced to or mixed with the sample in the collection tube. In this manner, there is no risk of user exposure to the reagent and no adverse impact on the ability to reliably mix reagent with sample. The device can then be shipped to a testing facility. Alternatively, a biomarker detection membrane may be used to detect more immediately, without shipping, presence or absence of a material in the sample. This provides for an almost instantaneous read-out that is incorporated into the self-collection device.
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