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1.发明授权Substituted 4-benzylaminoquinolines and their hetero analogs, process for their preparation, pharmaceuticals containing these compounds and use thereof 有权取代的4-苄基氨基喹啉及其杂类似物，其制备方法，含有这些化合物的药物及其用途公开(公告)号：US06339077B1
公开(公告)日：2002-01-15
申请号：US09667668
申请日：2000-09-22
IPC分类号： A61K3158
CPC分类号： C07J43/003 , C07J9/005 , C07J41/0055 , C07J41/0061
摘要： The invention relates to substituted 4-benzylaminoquinolines and their hetero analogs, and to the pharmaceutically acceptable salts and physiologically functional derivatives thereof. Compounds of formula I in which the radicals are defined in the specification, and their physiologically tolerated salts, physiologically functional derivatives and processes for their preparation are described. The compounds are suitable, for example, as medicines for the prophylaxis or treatment of gallstones.
摘要翻译： 本发明涉及取代的4-苄基氨基喹啉及其杂类似物，以及其药学上可接受的盐和生理功能衍生物。 描述了本说明书中定义的基团的式Iin化合物及其生理上耐受的盐，生理功能衍生物及其制备方法。 该化合物例如可用作预防或治疗胆结石的药物。
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2.发明授权Substituted acylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them 有权取代的酰基胍，其制备方法，用作药物或诊断剂，以及包含它们的药物公开(公告)号：US06451781B1
公开(公告)日：2002-09-17
申请号：US09655725
申请日：2000-09-05
申请人： Heinz-Werner Kleemann , Armin Hofmeister , Eugen Falk , Hans-Willi Jansen , Hans-Ludwig Schäfer
发明人： Heinz-Werner Kleemann , Armin Hofmeister , Eugen Falk , Hans-Willi Jansen , Hans-Ludwig Schäfer
IPC分类号： A61K3156
CPC分类号： C07J41/0061 , C07J9/005 , C07J41/0055
摘要： Substituted acylguanidines and their pharmaceutically tolerable salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the meanings indicated, and their physiologically tolerable salts, physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as medicaments for the prophylaxis or treatment of gallstones.
摘要翻译： 描述了取代的酰基胍及其药学上可耐受的盐和生理功能衍生物。描述了具有所示含义的基团的式Iin化合物及其生理上可耐受的盐，生理功能衍生物及其制备方法。 该化合物例如可用作预防或治疗胆结石的药物。
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3.发明授权Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权芳基环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07872034B2
公开(公告)日：2011-01-18
申请号：US12013806
申请日：2008-01-14
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/421 , C07D263/32 , A61P3/10
CPC分类号： C07D263/32 , C07D413/02
摘要： The invention relates to arylcycloalkyl-substituted alkanoic acid derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for the treatment and/or prevention of disorders of the fatty acid metabolism and glucose utilization disorders and also disorders in which insulin resistance is involved.
摘要翻译： 本发明涉及芳基环烷基取代的链烷酸衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 该化合物例如适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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4.发明授权Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals 有权二芳基环烷基衍生物，其制备方法及其作为药剂学的用途公开(公告)号：US07399777B2
公开(公告)日：2008-07-15
申请号：US11097345
申请日：2005-04-04
申请人： Heiner Glombik , Eugen Falk , Wendelin Frick , Stefanie Keil , Hans-Ludwig Schäfer , Lothar Schwink , Wolfgang Wendler
发明人： Heiner Glombik , Eugen Falk , Wendelin Frick , Stefanie Keil , Hans-Ludwig Schäfer , Lothar Schwink , Wolfgang Wendler
IPC分类号： C07D263/32 , A61K31/421
CPC分类号： C07D263/32 , C07D413/12
摘要： Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.
摘要翻译： 公开了二芳基环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 化合物包括其中基团如所定义的式I化合物及其生理上可接受的盐及其制备方法。 化合物通常具有降低脂质和/或甘油三酯的性质，并且适合于例如用于治疗脂质代谢紊乱，II型糖尿病和X综合症。
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5.发明授权Cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07365084B2
公开(公告)日：2008-04-29
申请号：US10788997
申请日：2004-02-27
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： C07D413/02 , C07D263/30 , A61K31/4439 , A61K31/422
CPC分类号： C07D263/32 , C07D413/02
摘要： Provided herein are cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals.
摘要翻译： 本文提供环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途。
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6.发明授权Cycloalkylmethoxy-substituted acetic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基甲氧基取代的乙酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07259177B2
公开(公告)日：2007-08-21
申请号：US10788996
申请日：2004-02-27
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/42 , C07D263/30
CPC分类号： C07D263/32 , C07D413/02
摘要： Provided herein are novel compounds of formula I below: in which the radicals are as defined, their physiologically acceptable salts, processes for their preparation, as well as methods of treating and/or preventing disorders of disorders of fatty acid metabolism and glucose utilization disorders, and also of disorders in which insulin resistance is involved, in a patient.
摘要翻译： 本文提供了下文式I的新化合物：其中基团如所定义，其生理学上可接受的盐，其制备方法，以及治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍疾病的方法， 以及患有胰岛素抵抗的疾病。
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7.发明授权Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals 有权磺酰甲酰胺衍生物，其制备方法及其作为药物的用途公开(公告)号：US06342512B1
公开(公告)日：2002-01-29
申请号：US09654841
申请日：2000-09-01
IPC分类号： C07D21114
CPC分类号： C07D295/26 , C07D211/14 , C07D211/58 , C07D211/70 , C07D213/38 , C07D295/13 , C07D333/20
摘要： Sulfonylcarboxamide derivatives of formula I, their physiologically acceptable salts and/or physiologically functional derivatives, methods of making these compounds, their use for preparing medicines for the prevention and treatment of hyperlipidemia and arteriosclerotic disorders. The compounds of formula I have the following structure: in which the radicals are as defined and their physiologically acceptable salts and physiologically functional derivatives are described.
摘要翻译： 式I的磺酰基甲酰胺衍生物，其生理上可接受的盐和/或生理功能衍生物，制备这些化合物的方法，其用于制备用于预防和治疗高脂血症和动脉硬化性疾病的药物的用途。 式I化合物具有以下结构：其中基团如所定义，并且描述了它们的生理上可接受的盐和生理功能衍生物。
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![N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, pharmaceutical compositions thereof and methods for their therapeutic use](/abs-image/US/2010/12/28/US07858647B2/abs.jpg.150x150.jpg)
8.发明授权N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, pharmaceutical compositions thereof and methods for their therapeutic use 有权N- [1,3,4] - 噻二唑-2-基 - 苯磺酰胺，其药物组合物及其治疗用途的方法公开(公告)号：US07858647B2
公开(公告)日：2010-12-28
申请号：US12062764
申请日：2008-04-04
申请人： Stefanie Keil , Hans Matter , Karl Schoenafinger , Matthias Urmann , Maike Glien , Wolfgang Wendler , Hans-Ludwig Schaefer , Eugen Falk
发明人： Stefanie Keil , Hans Matter , Karl Schoenafinger , Matthias Urmann , Maike Glien , Wolfgang Wendler , Hans-Ludwig Schaefer , Eugen Falk
IPC分类号： A61K31/4436 , A61K31/433 , C07D417/12 , C07D285/135
CPC分类号： C07D417/12 , C07D285/135
摘要： The present invention comprises N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their physiologically acceptable salts and functional derivatives that exhibit peroxisome proliferator activated receptor (PPAR) PPARdelta and PPARgamma agonist activity. The structure of the compounds of the invention are defined by Formula I below, And the isomers thereof wherein the various substituents are defined herein, including their physiologically acceptable salts. Processes for the compounds preparation are also disclosed. The compounds are suitable for the treatment of fatty acid metabolism and glucose utilization disorders, disorders relating to insulin resistance are involved as well as demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
摘要翻译： 本发明包括显示过氧化物酶体增殖物激活受体（PPAR）PPARδ和PPARγ激动剂活性的N- [1,3,4] - 噻二唑-2-基 - 苯磺酰胺，其生理上可接受的盐和功能性衍生物。 本发明化合物的结构由下式I定义，其各种取代基在本文中定义的异构体，包括其生理上可接受的盐。 还公开了化合物制备的方法。 该化合物适用于治疗脂肪酸代谢和葡萄糖利用障碍，涉及胰岛素抵抗的疾病以及中枢和周围神经系统的脱髓鞘和其他神经变性疾病。
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9.发明授权Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07173151B2
公开(公告)日：2007-02-06
申请号：US10789324
申请日：2004-02-27
申请人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： C07C229/00 , C07C61/28 , C07C61/16 , C07C62/00 , C07C62/30
CPC分类号： C07C275/28 , C07C275/10 , C07C275/24 , C07C275/26 , C07C2601/14
摘要： The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 本发明涉及芳基环烷基取代的衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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10.发明授权Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals 有权具有生物异丝氨酸羧酸基团的环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US07148246B2
公开(公告)日：2006-12-12
申请号：US10789865
申请日：2004-02-27
申请人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
发明人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： C07D277/04 , C07D209/54 , C07D257/04 , C07D413/00 , A61K31/42
CPC分类号： C07D417/12 , C07D263/32 , C07D413/12
摘要： Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals The invention relates to cycloalkyl derivatives having bioisosteric carboxylic acid groups and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 具有生物硅烷酸羧酸基团的环烷基衍生物及其制备方法及其作为药物的用途本发明涉及具有生物硅烷酸羧酸基团的环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 所描述的是式I化合物，其中自由基如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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