公开(公告)号：US20050130889A1

公开(公告)日：2005-06-16

申请号：US10629516

申请日：2003-07-29

申请人： Arnold Horwitz ,  Stephen Carroll ,  David Burke

发明人： Arnold Horwitz ,  Stephen Carroll ,  David Burke

IPC分类号： C12N15/09 ,  A01N37/18 ,  A61K38/00 ,  A61K38/16 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/47 ,  C12N5/00 ,  C12N5/10 ,  C12N9/48 ,  C12N15/31 ,  C12N15/74 ,  C12P21/02 ,  C12P21/06 ,  C12R1/91

CPC分类号： A61K38/17 ,  C07K14/4742

摘要： Novel BPI deletion analogs are provided that consist of amino acid residues 10 through 193 of mature human BPI wherein the cysteine residue at BPI amino acid position 132 is replaced by another amino acid. Fusion proteins comprising these analogs are also provided, as are polynucleotides encoding these products, materials and methods for their recombinant production, compositions and medicaments of these products, and therapeutic uses for these products.

摘要翻译： 提供了由成熟人BPI的氨基酸残基10至193组成的新型BPI缺失类似物，其中BPI氨基酸位置132处的半胱氨酸残基被另一个氨基酸替代。 还提供了包含这些类似物的融合蛋白，编码这些产物的多核苷酸，其重组生产的材料和方法，这些产品的组合物和药物以及这些产品的治疗用途。

公开(公告)号：US08201987B2

公开(公告)日：2012-06-19

申请号：US12717949

申请日：2010-03-04

申请人： Stephen Carroll

发明人： Stephen Carroll

IPC分类号： B01F11/00

CPC分类号： B01F11/0008 ,  A21C1/006 ,  A47J43/04 ,  B01F11/0014 ,  B01F15/00253

摘要： A kitchen shaking apparatus includes a housing, a controllable oscillating actuator contained in the housing, a platform mechanically coupled to the controllable oscillating actuator, and a plurality of adjustable coacting restraining arms operably coupled to the housing. Each of the restraining arms including a vertical segment and a horizontal segment and is positioned and configured to allow the vertical segment to contact an object on the platform. A speed control is configured to control frequency of oscillation of the actuator. A timer control is configured to control duration of operation of the actuator. A locking mechanism releasably locks at least one adjustable restraining arm at a user-selectable position. A removable pad is attached to the top surface of the platform. After shaking mixed ingredients using the apparatus, the ingredients are devoid of substantial air pockets and the consistency is improved for an enhanced processed food product.

摘要翻译： 厨房摇动装置包括壳体，容纳在壳体中的可控振荡致动器，机械地联接到可控振动致动器的平台以及可操作地联接到壳体的多个可调节的联合限制臂。 每个约束臂包括垂直段和水平段，并且被定位和构造成允许垂直段与平台上的物体接触。 速度控制被配置为控制致动器的振荡频率。 定时器控制被配置为控制致动器的操作持续时间。 锁定机构可释放地将至少一个可调节的限制臂锁定在用户可选择的位置。 可拆卸的垫子连接到平台的顶部表面。 在使用该装置搅拌混合成分之后，成分没有实质的空气袋，并且对于增强的加工食品而言，一致性得到改善。

公开(公告)号：USD555892S1

公开(公告)日：2007-11-27

申请号：US29275387

申请日：2006-12-22

申请人： Stephen Carroll

设计人： Stephen Carroll

公开(公告)号：US08807648B2

公开(公告)日：2014-08-19

申请号：US12903393

申请日：2010-10-13

申请人： Stephen Carroll

发明人： Stephen Carroll

IPC分类号： A47C7/62

CPC分类号： A47C7/62

摘要： A storage assembly for use with a chair. The chair has a seat supported by a framework such as one or more legs. The storage assembly includes at least one storage unit, preferably a plurality of storage units, each having at least one storage feature, such as a recess, drawer, hook, container or case. The storage assembly is attachable to the seat or the supportive framework of the chair below the seat of the chair, and does not protrude substantially therefrom. In an embodiment with a plurality of shelves, the shelves are connected to a support structure such as a pair of side walls. One or more leg attachments operably couple the assembly to one or more chair legs. For example, a leg attachment may connect a wall to a leg. As each shelf is connected to the wall, the leg attachment couples the shelf to the leg, via the wall. The leg attachment may be a pivoting, telescopic arm with a clamp, a belt, snap fit, integrally molded or other suitable connector. The storage assembly may be permanently or removably attached to the chair.

摘要翻译： 一个用于椅子的存储组件。 椅子具有由诸如一个或多个腿部的框架支撑的座位。 存储组件包括至少一个存储单元，优选地多个存储单元，每个存储单元具有至少一个存储特征，例如凹槽，抽屉，钩，容器或壳体。 存储组件可附接到椅子的座椅或座椅的支撑框架下方，并且基本不从其突出。 在具有多个架子的实施例中，搁架连接到诸如一对侧壁的支撑结构。 一个或多个腿部附件可操作地将组件耦合到一个或多个椅子腿部。 例如，腿部附件可以将墙壁连接到腿部。 当每个搁架连接到墙壁时，腿部附件通过墙壁将搁架连接到腿部。 腿部附件可以是具有夹具，带，卡扣配合，整体模制或其它合适的连接器的枢转的伸缩臂。 存储组件可以永久地或可拆卸地附接到椅子上。

公开(公告)号：US20060074550A1

公开(公告)日：2006-04-06

申请号：US11202859

申请日：2005-08-11

申请人： Carl Freer ,  Stephen Carroll

发明人： Carl Freer ,  Stephen Carroll

IPC分类号： G01C21/30

CPC分类号： G06Q30/02 ,  H04L67/18 ,  H04L67/38 ,  H04W4/029

摘要： A system and method for distributing multimedia content to a mobile wireless platform of the present invention. In an illustrative embodiment, the inventive system includes memory for receiving and storing said multimedia content; a controller for automatically transmitting said content; and a wireless platform for automatically receiving, storing and playing out said content. In a specific implementation, the receipt, storage and playback functions are implemented with an applet running on the platform. The content may be transmitted using Global Packet Radio Service (GPRS), Code Division Multiple Access (CDMA) or other suitable network. The applet includes a decoder and code for decompressing said multimedia content. In one embodiment, the system is adapted to transmit multimedia content to a selected mobile wireless platform based on a location thereof. This may be implemented with a GPS receiver or by using cellular position location services. The system includes a server which retrieves data delivery metrics from a database and generates multimedia messages for selected devices accordingly. In the illustrative embodiment, the server generates a schedule file for the playback of the messages and sends messages to the wireless platforms to download the schedule. The schedule file includes a message file address. The applet downloads the schedule file and extracts the message file address. This address is used to download the multimedia message. The message is output in accordance with the schedule. Data relating to the output of the multimedia file is stored for feedback to the server.

摘要翻译： 一种用于将多媒体内容分发到本发明的移动无线平台的系统和方法。 在说明性实施例中，本发明的系统包括用于接收和存储所述多媒体内容的存储器; 用于自动发送所述内容的控制器; 以及用于自动接收，存储和播放所述内容的无线平台。 在具体实现中，接收，存储和回放功能是在平台上运行的小应用程序实现的。 可以使用全局分组无线业务（GPRS），码分多址（CDMA）或其他合适的网络来发送内容。 小应用程序包括用于解压缩所述多媒体内容的解码器和代码。 在一个实施例中，该系统适于基于其位置将多媒体内容传输到所选择的移动无线平台。 这可以用GPS接收机或通过使用蜂窝定位服务来实现。 该系统包括从数据库检索数据传送指标并相应地为所选择的设备生成多媒体消息的服务器。 在说明性实施例中，服务器生成用于回放消息的调度文件，并向无线平台发送消息以下载该调度。 时间表文件包括一个消息文件地址。 小程序下载计划文件并提取消息文件地址。 该地址用于下载彩信。 消息按照时间表输出。 与多媒体文件的输出有关的数据被存储以供反馈给服务器。

公开(公告)号：US20050054835A1

公开(公告)日：2005-03-10

申请号：US10717243

申请日：2003-11-18

申请人： Marc Better ,  Stephen Carroll ,  Gary Studnicka

发明人： Marc Better ,  Stephen Carroll ,  Gary Studnicka

IPC分类号： A61K38/00 ,  A61K47/48 ,  A61P35/00 ,  A61P37/06 ,  C07K14/415 ,  C07K16/00 ,  C07K16/16 ,  C07K16/28 ,  C12N1/21 ,  C12N15/29 ,  C07H21/04 ,  C07K16/46 ,  C12N5/06 ,  C12N15/74 ,  C12P21/04

CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K47/6825 ,  A61K47/6849 ,  A61K2121/00 ,  C07K16/00 ,  C07K16/16 ,  C07K16/28 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/00 ,  Y10S530/866

摘要： The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.

摘要翻译： 本发明提供了编码I型核糖体失活蛋白（RIP）的纯化和分离的多核苷酸以及具有可用于二硫键与靶向分子的半胱氨酸的RIP的类似物。 还提供了包含用载体转化的多核苷酸和宿主细胞的载体。 RIP和RIP类似物特别适合用作本发明的细胞毒性治疗剂的组分，其包括基因融合产物和免疫缀合物。 根据本发明的细胞毒性治疗剂或免疫毒素可以用于选择性地消除RIP组分靶向的任何细胞类型，其中药剂的第二组分的特异性结合能力，并且适用于治疗消除 特定的细胞类型是目标，例如自身免疫疾病，癌症和移植物抗宿主病。

公开(公告)号：US20120091765A1

公开(公告)日：2012-04-19

申请号：US12903393

申请日：2010-10-13

申请人： Stephen Carroll

发明人： Stephen Carroll

IPC分类号： A47C7/62

CPC分类号： A47C7/62

摘要： A storage assembly for use with a chair. The chair has a seat supported by a framework such as one or more legs. The storage assembly includes at least one storage unit, preferably a plurality of storage units, each having at least one storage feature, such as a recess, drawer, hook, container or case. The storage assembly is attachable to the seat or the supportive framework of the chair below the seat of the chair, and does not protrude substantially therefrom. In an embodiment with a plurality of shelves, the shelves are connected to a support structure such as a pair of side walls. One or more leg attachments operably couple the assembly to one or more chair legs. For example, a leg attachment may connect a wall to a leg. As each shelf is connected to the wall, the leg attachment couples the shelf to the leg, via the wall. The leg attachment may be a pivoting, telescopic arm with a clamp, a belt, snap fit, integrally molded or other suitable connector. The storage assembly may be permanently or removably attached to the chair.

摘要翻译： 一个用于椅子的存储组件。 椅子具有由诸如一个或多个腿部的框架支撑的座位。 存储组件包括至少一个存储单元，优选地多个存储单元，每个存储单元具有至少一个存储特征，例如凹槽，抽屉，钩，容器或壳体。 存储组件可附接到椅子的座椅或座椅的支撑框架下方，并且基本不从其突出。 在具有多个架子的实施例中，搁架连接到诸如一对侧壁的支撑结构。 一个或多个腿部附件可操作地将组件耦合到一个或多个椅子腿部。 例如，腿部附件可以将墙壁连接到腿部。 当每个搁架连接到墙壁时，腿部附件通过墙壁将搁架连接到腿部。 腿部附件可以是具有夹具，带，卡扣配合，整体模制或其它合适的连接器的枢转的伸缩臂。 存储组件可以永久地或可拆卸地附接到椅子上。

公开(公告)号：USD554851S1

公开(公告)日：2007-11-13

申请号：US29275381

申请日：2006-12-22

申请人： Stephen Carroll

设计人： Stephen Carroll

公开(公告)号：US20050209837A1

公开(公告)日：2005-09-22

申请号：US10960853

申请日：2004-10-07

申请人： Lesa Beamer ,  Stephen Carroll ,  David Eisenberg

发明人： Lesa Beamer ,  Stephen Carroll ,  David Eisenberg

IPC分类号： G06G7/48 ,  G06G7/58

CPC分类号： C07K14/4742 ,  C07K2299/00 ,  G16B15/00

摘要： The present invention solves the three-dimensional structure of BPI and thereby provides atomic coordinates of BPI from the analysis of x-ray diffraction patterns of sufficiently high resolution for three-dimensional structure determination of the protein, as well as methods for rational drug design, based on using amino acid sequence data and/or x-ray diffraction data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms; and atomic coordinates are provided yielding structural information on related proteins, including the lipid binding and lipid transport protein family that includes BPI, LBP, CETP and PLTP.

摘要翻译： 本发明解决了BPI的三维结构，从而提供了足够高分辨率的x射线衍射图谱的分析用于蛋白质的三维结构测定的BPI的原子坐标，以及合理的药物设计方法， 基于在具有合适的计算机算法的计算机系统上分析的使用在计算机可读介质上提供的氨基酸序列数据和/或x射线衍射数据; 并提供原子坐标，产生相关蛋白质的结构信息，包括脂质结合和脂质转运蛋白家族，包括BPI，LBP，CETP和PLTP。