公开(公告)号：US20110313515A1

公开(公告)日：2011-12-22

申请号：US13165721

申请日：2011-06-21

申请人： Arshad Quadri ,  J. Brent Ratz ,  Yen Liao ,  Stan Komatsu ,  Kalathi Thygarajan ,  Robrecht Michiels ,  Hung Nguyen ,  MyKim Nguyen

发明人： Arshad Quadri ,  J. Brent Ratz ,  Yen Liao ,  Stan Komatsu ,  Kalathi Thygarajan ,  Robrecht Michiels ,  Hung Nguyen ,  MyKim Nguyen

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0029 ,  A61F2250/0039

摘要： A replacement heart valve can have an expandable frame configured to engage a native valve annulus. A valve body can be mounted onto the expandable frame to provide functionality similar to a natural valve. The valve body has an upstream end and a downstream end, and a diameter at the downstream end is greater than a diameter at the upstream end.

摘要翻译： 替换心脏瓣膜可以具有被构造为接合天然瓣膜环的可扩张框架。 阀体可以安装在可膨胀框架上，以提供类似于自然阀的功能。 阀体具有上游端和下游端，下游端的直径大于上游端的直径。

公开(公告)号：US09730790B2

公开(公告)日：2017-08-15

申请号：US13403929

申请日：2012-02-23

申请人： Arshad Quadri ,  J. Brent Ratz ,  Robrecht Michiels

发明人： Arshad Quadri ,  J. Brent Ratz ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2439 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0039 ,  A61F2250/006 ,  A61F2250/0069 ,  A61F2250/0071

摘要： A replacement valve has an expandable frame configured to engage a native valve and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.

公开(公告)号：US20120215303A1

公开(公告)日：2012-08-23

申请号：US13403929

申请日：2012-02-23

申请人： Arshad Quadri ,  J. Brent Ratz ,  Robrecht Michiels

发明人： Arshad Quadri ,  J. Brent Ratz ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2439 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0039 ,  A61F2250/006 ,  A61F2250/0069 ,  A61F2250/0071

摘要： A replacement heart valve has an expandable frame configured to engage a native valve annulus and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.

摘要翻译： 替换心脏瓣膜具有被构造成接合天然瓣膜环的可膨胀框架和安装到可扩张框架的阀体。 阀体可以具有多个阀单元，其构造成打开以允许在第一方向上流动并且彼此接合，以便关闭并防止在第二方向上流动，第二方向与第一方向相反。

公开(公告)号：US09060857B2

公开(公告)日：2015-06-23

申请号：US13526951

申请日：2012-06-19

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US20060265056A1

公开(公告)日：2006-11-23

申请号：US11433296

申请日：2006-05-12

申请人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

公开(公告)号：US20060259136A1

公开(公告)日：2006-11-16

申请号：US11128826

申请日：2005-05-13

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

公开(公告)号：US09504564B2

公开(公告)日：2016-11-29

申请号：US11433296

申请日：2006-05-12

申请人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

公开(公告)号：USD732666S1

公开(公告)日：2015-06-23

申请号：US29399122

申请日：2011-08-09

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

设计人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

公开(公告)号：US20120259409A1

公开(公告)日：2012-10-11

申请号：US13526951

申请日：2012-06-19

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US20150127095A9

公开(公告)日：2015-05-07

申请号：US13526951

申请日：2012-06-19

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。