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公开(公告)号：US08039597B2
公开(公告)日：2011-10-18
申请号：US12205560
申请日：2008-09-05
申请人： Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Steven B. Kanner , Pia M. Challita-Eid , Xiao-chi Jia , Jean Gudas , Aya Jakobovits
发明人： Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Steven B. Kanner , Pia M. Challita-Eid , Xiao-chi Jia , Jean Gudas , Aya Jakobovits
CPC分类号： A61K51/1051 , A61K39/00 , A61K39/0011 , A61K47/6809 , A61K47/6821 , A61K47/6823 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0013 , A61K51/1054 , A61K51/1057 , A61K51/1072 , A61K2039/505 , A61K2039/5152 , C07K14/47 , C07K14/4748 , C07K16/303 , C07K16/3069 , C07K2317/21 , C07K2317/56 , C07K2317/732 , C07K2317/77 , G01N33/57484 , G01N2500/00
摘要： Antibodies and molecules derived therefrom that bind to 24P4C12 protein and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断，预后，预防和预后， /或癌症治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20090214556A1
公开(公告)日：2009-08-27
申请号：US12433760
申请日：2009-04-30
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-Chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-Chi Jia , Jean Gudas
IPC分类号： A61K39/395 , C07K16/18 , C12N9/96 , C12N5/06 , G01N33/53
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08350009B2
公开(公告)日：2013-01-08
申请号：US12757935
申请日：2010-04-09
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/732
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08236310B2
公开(公告)日：2012-08-07
申请号：US12881461
申请日：2010-09-14
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20090175796A1
公开(公告)日：2009-07-09
申请号：US12205560
申请日：2008-09-05
申请人： Arthur B. RAITANO , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Steven B. Kanner , Pia M. Challita-Eid , Xiao-chi Jia , Jean Gudas , Aya Jakobovits
发明人： Arthur B. RAITANO , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Steven B. Kanner , Pia M. Challita-Eid , Xiao-chi Jia , Jean Gudas , Aya Jakobovits
IPC分类号： A61K49/00 , C07K16/18 , A01K67/00 , C12N5/00 , C12N15/63 , G01N33/53 , A61K39/395 , C07H21/02 , C12Q1/68 , A61K31/7052 , C40B30/04 , A61P35/00
CPC分类号： A61K51/1051 , A61K39/00 , A61K39/0011 , A61K47/6809 , A61K47/6821 , A61K47/6823 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0013 , A61K51/1054 , A61K51/1057 , A61K51/1072 , A61K2039/505 , A61K2039/5152 , C07K14/47 , C07K14/4748 , C07K16/303 , C07K16/3069 , C07K2317/21 , C07K2317/56 , C07K2317/732 , C07K2317/77 , G01N33/57484 , G01N2500/00
摘要： Antibodies and molecules derived therefrom that bind to 24P4C12 protein and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断，预后，预防和预后， /或癌症治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20100260756A1
公开(公告)日：2010-10-14
申请号：US12757935
申请日：2010-04-09
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
IPC分类号： A61K39/395 , C07K16/00 , G01N33/574 , A61P35/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/732
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20090022663A1
公开(公告)日：2009-01-22
申请号：US12196039
申请日：2008-08-21
申请人： Aya JAKOBOVITS , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-Chi Jia , Jean Gudas
发明人： Aya JAKOBOVITS , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-Chi Jia , Jean Gudas
IPC分类号： A61K51/00 , C12N5/06 , A61P31/00 , A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
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公开(公告)号：US07427399B2
公开(公告)日：2008-09-23
申请号：US11396178
申请日：2006-03-31
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20110020353A1
公开(公告)日：2011-01-27
申请号：US12881461
申请日：2010-09-14
申请人： Aya JAKOBOVITS , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-Chi Jia , Jean Gudas
发明人： Aya JAKOBOVITS , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-Chi Jia , Jean Gudas
IPC分类号： A61K39/395 , C07K16/18 , C07K16/46 , A61P35/00 , C12N9/96 , C12N5/16 , C12N5/07 , G01N33/566
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07811565B2
公开(公告)日：2010-10-12
申请号：US12433760
申请日：2009-04-30
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
IPC分类号： A16K39/395 , G01N33/574 , C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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