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公开(公告)号:US5767120A
公开(公告)日:1998-06-16
申请号:US479418
申请日:1995-06-06
申请人: Pauline C. Ting , Daniel M. Solomon , Richard J. Friary , John J. Piwinski , Joe F. Lee , Vera A. Seidl , James P. Jakway
发明人: Pauline C. Ting , Daniel M. Solomon , Richard J. Friary , John J. Piwinski , Joe F. Lee , Vera A. Seidl , James P. Jakway
IPC分类号: C07D295/02 , A61K31/125 , A61K31/135 , A61K31/18 , A61K31/195 , A61K31/335 , A61K31/40 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/44 , A61K31/443 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00 , C07C33/38 , C07C45/44 , C07C47/235 , C07C47/453 , C07C69/608 , C07C69/618 , C07C211/26 , C07C211/32 , C07C215/42 , C07C217/52 , C07C229/14 , C07C233/05 , C07C233/18 , C07C233/73 , C07C251/40 , C07C271/10 , C07C271/12 , C07C271/16 , C07C311/03 , C07C311/04 , C07C311/17 , C07D207/16 , C07D209/08 , C07D209/44 , C07D209/48 , C07D213/89 , C07D221/16 , C07D261/02 , C07D295/03 , C07D295/084 , C07D313/12 , C07D405/06 , C07D401/00 , A61K31/495 , C07D221/00
CPC分类号: C07D295/03 , A61K31/00 , A61K31/135 , C07C211/32 , C07C217/52 , C07C229/14 , C07C233/18 , C07C233/73 , C07C251/40 , C07C271/12 , C07C271/16 , C07C311/04 , C07C311/17 , C07D221/16 , C07D295/092 , C07D313/12 , C07C2101/02 , C07C2103/32
摘要: Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl;R.sup.4 is H, alkyl, alkenyl, alkoxy, or --OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.
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公开(公告)号:US5538986A
公开(公告)日:1996-07-23
申请号:US162744
申请日:1993-12-06
申请人: Pauline C. Ting , Daniel M. Solomon , Richard J. Friary , Frank J. Villani , John J. Piwinski , Joe F. Lee , Dhiru B. Vashi
发明人: Pauline C. Ting , Daniel M. Solomon , Richard J. Friary , Frank J. Villani , John J. Piwinski , Joe F. Lee , Dhiru B. Vashi
IPC分类号: C07D295/02 , A61K31/125 , A61K31/135 , A61K31/18 , A61K31/195 , A61K31/335 , A61K31/40 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/44 , A61K31/443 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00 , C07C33/38 , C07C45/44 , C07C47/235 , C07C47/453 , C07C69/608 , C07C69/618 , C07C211/26 , C07C211/32 , C07C215/42 , C07C217/52 , C07C229/14 , C07C233/05 , C07C233/18 , C07C233/73 , C07C251/40 , C07C271/10 , C07C271/12 , C07C271/16 , C07C311/03 , C07C311/04 , C07C311/17 , C07D207/16 , C07D209/08 , C07D209/44 , C07D209/48 , C07D213/89 , C07D221/16 , C07D261/02 , C07D295/03 , C07D295/084 , C07D313/12 , C07D405/06 , C07D313/00 , A61K31/35 , A61K31/41 , C07C211/00 , C07C233/00 , A61K31/138
CPC分类号: C07D295/03 , A61K31/00 , A61K31/135 , C07C211/32 , C07C217/52 , C07C229/14 , C07C233/18 , C07C233/73 , C07C251/40 , C07C271/12 , C07C271/16 , C07C311/04 , C07C311/17 , C07D221/16 , C07D295/092 , C07D313/12 , C07C2101/02 , C07C2103/32
摘要: Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl;R.sup.4 is H, alkyl, alkenyl, alkoxy, or --OH.Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.
摘要翻译: 公开了式I的化合物:其中:R 3是烷基,烯基,炔基,芳基,烷芳基,芳烷基,环烷基,酰氧基甲基,烷氧基,烷氧基甲基或被 环烷基 R4是H,烷基,烯基,烷氧基或-OH。 还公开了含有式I化合物,抑制肿瘤坏死因子-α的药物组合物和通过给予式I化合物治疗败血性休克,炎症或过敏性疾病的方法的药物组合物。
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公开(公告)号:US5574173A
公开(公告)日:1996-11-12
申请号:US162686
申请日:1993-12-06
申请人: Pauline C. Ting , Richard J. Friary , Wing C. Tom , Joe F. Lee , Vera A. Seidl
发明人: Pauline C. Ting , Richard J. Friary , Wing C. Tom , Joe F. Lee , Vera A. Seidl
IPC分类号: C07D211/14 , A61K31/135 , A61K31/165 , A61K31/335 , A61K31/445 , A61K31/451 , A61P29/00 , A61P37/08 , C07C211/31 , C07C211/32 , C07C215/20 , C07C215/38 , C07C217/16 , C07C217/48 , C07C233/05 , C07C233/13 , C07C235/34 , C07D211/70 , C07D313/12 , C07D313/10
CPC分类号: C07C211/32 , C07C215/38 , C07C217/48 , C07C233/13 , C07D313/12
摘要: Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.4 is alkenyl, alkoxy, or --OH.Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha., and methods for treating septic shock, inflammation, or allergic disease.
摘要翻译: 公开了式I的化合物:其中:R4是烯基,烷氧基或-OH。 还公开了含有式I化合物,抑制肿瘤坏死因子-α的方法,以及治疗败血性休克,炎症或过敏性疾病的方法的药物组合物。
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公开(公告)号:US20110224136A1
公开(公告)日:2011-09-15
申请号:US13129830
申请日:2009-11-17
申请人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , David Kim , Hyunjin Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Gang Zhou , Nicolas Zorn
发明人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , David Kim , Hyunjin Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Gang Zhou , Nicolas Zorn
IPC分类号: A61K38/28 , C07D409/14 , C07D413/14 , C07D401/14 , C07D211/32 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K31/445 , A61K31/454 , A61K31/4545 , A61P3/04 , A61P3/10
CPC分类号: C07D413/14 , C07D401/12 , C07D401/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below.
摘要翻译: 本发明涉及作为二酰基甘油酰基转移酶(“DGAT”)抑制剂的新型杂环化合物,包含杂环化合物的药物组合物和用于治疗或预防心血管疾病,代谢障碍,肥胖症或肥胖相关障碍的化合物的用途, 糖尿病,血脂异常,糖尿病并发症,葡萄糖耐量降低或空腹血糖受损。 本发明的说明性化合物如下所示。
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公开(公告)号:US07919505B2
公开(公告)日:2011-04-05
申请号:US11775383
申请日:2007-07-10
申请人: Pauline C. Ting , Joe F. Lee , Kung-I Feng , Michael R. Reeder , Scott T. Trzaska , Man Zhu , Chen Mao , Dimitar L. Filipov , Dimitrios N. Zarkadas
发明人: Pauline C. Ting , Joe F. Lee , Kung-I Feng , Michael R. Reeder , Scott T. Trzaska , Man Zhu , Chen Mao , Dimitar L. Filipov , Dimitrios N. Zarkadas
IPC分类号: C07D215/38 , A61K31/04
CPC分类号: C07D413/14
摘要: The present invention relates to the compound of the formula To methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to polymorphs and processes of synthesis of the polymorphic forms.
摘要翻译: 本发明涉及式的化合物:使用所述化合物,包含它的制剂治疗上下阻塞性气道疾病的方法以及多晶型物和多晶型物合成方法。
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公开(公告)号:US20110224193A1
公开(公告)日:2011-09-15
申请号:US13129821
申请日:2009-11-17
申请人: Pauline C. Ting , Robert Aslanian , Jianhua Cao , Mary Ann Caplen , Tin-Yau Chan , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , Heping Wu
发明人: Pauline C. Ting , Robert Aslanian , Jianhua Cao , Mary Ann Caplen , Tin-Yau Chan , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , Heping Wu
IPC分类号: A61K31/5513 , C07D413/14 , A61K31/4545 , A61K31/497 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P3/08
CPC分类号: C07D413/12 , A61K31/422 , A61K31/427 , C07D213/74 , C07D401/04 , C07D403/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D493/10
摘要: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown with this abstract.
摘要翻译: 本发明涉及作为二酰基甘油酰基转移酶(“DGAT”)抑制剂的新型杂环化合物,包含杂环化合物的药物组合物和用于治疗或预防心血管疾病,代谢障碍,肥胖症或肥胖相关障碍的化合物的用途, 糖尿病,血脂异常,糖尿病并发症,葡萄糖耐量降低或空腹血糖受损。 本摘要显示了本发明的说明性化合物。
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公开(公告)号:US20110224137A1
公开(公告)日:2011-09-15
申请号:US13129843
申请日:2009-11-17
申请人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
发明人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
IPC分类号: A61K38/28 , C07D409/14 , C07D243/08 , C07D401/14 , C07D221/00 , C07D211/06 , A61K31/497 , A61K31/551 , A61K31/4545 , A61K31/438 , A61K31/454 , A61P3/04 , A61P3/10
CPC分类号: C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04
摘要: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: formula (I).
摘要翻译: 本发明涉及作为二酰基甘油酰基转移酶(“DGAT”)抑制剂的新型杂环化合物,包含杂环化合物的药物组合物和用于治疗或预防心血管疾病,代谢障碍,肥胖症或肥胖相关障碍的化合物的用途, 糖尿病,血脂异常,糖尿病并发症,葡萄糖耐量降低或空腹血糖受损。 本发明的说明性化合物如下所示:式(I)。
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公开(公告)号:US08716312B2
公开(公告)日:2014-05-06
申请号:US13129843
申请日:2009-11-17
申请人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
发明人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
IPC分类号: A61P3/00 , A61P9/00 , A61K31/445 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04
摘要: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below:
摘要翻译: 本发明涉及作为二酰基甘油酰基转移酶(“DGAT”)抑制剂的新型杂环化合物,包含杂环化合物的药物组合物和用于治疗或预防心血管疾病,代谢障碍,肥胖症或肥胖相关障碍的化合物的用途, 糖尿病,血脂异常,糖尿病并发症,葡萄糖耐量降低或空腹血糖受损。 本发明的说明性化合物如下所示:
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公开(公告)号:US20120172369A1
公开(公告)日:2012-07-05
申请号:US13395589
申请日:2010-09-03
申请人: Pauline C. Ting , Joe F. Lee , Robert G. Aslanian
发明人: Pauline C. Ting , Joe F. Lee , Robert G. Aslanian
IPC分类号: A61K31/506 , C07D409/14 , C07D405/12 , A61K31/496 , A61P3/06 , A61K31/443 , A61K31/444 , A61K31/4525 , A61P3/04 , A61P3/10 , C07D405/14 , A61K31/4545
CPC分类号: C07D405/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (DGAT) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below:
摘要翻译: 本发明涉及作为二酰基甘油酰基转移酶(DGAT)抑制剂的新型杂环化合物,包含杂环化合物的药物组合物和用于治疗或预防心血管疾病,代谢障碍,肥胖或肥胖相关病症,糖尿病, 血脂异常,糖尿病并发症,葡萄糖耐量降低或空腹血糖受损。 本发明的说明性化合物如下所示:
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