-
公开(公告)号：US20110206697A1
公开(公告)日：2011-08-25
申请号：US13023694
申请日：2011-02-09
申请人： Arul M. Chinnaiyan , Bushra Ateeq , Scott Tomlins
发明人： Arul M. Chinnaiyan , Bushra Ateeq , Scott Tomlins
IPC分类号： A61K39/395 , C12N5/071 , C12N5/09 , A61P35/00 , C07K16/18
CPC分类号： C07K16/38 , A61K2039/505 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to SPINK1 as a clinical target for prostate cancer.
摘要翻译： 本发明涉及用于癌症治疗的组合物和方法，包括但不限于癌症标志物的靶向抑制。 特别地，本发明涉及SPINK1作为前列腺癌的临床靶标。
-
公开(公告)号：US20110028336A1
公开(公告)日：2011-02-03
申请号：US12667819
申请日：2008-07-03
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要： Compositions and methods associated with recurrent MIPOL1-ETV1 genetic rearrangements that are useful for cancer diagnosis and therapy are disclosed.
摘要翻译： 公开了可用于癌症诊断和治疗的复发性MIPOL1-ETV1遗传重排相关的组合物和方法。
-
公开(公告)号：US09303291B2
公开(公告)日：2016-04-05
申请号：US12667819
申请日：2008-07-03
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要： Compositions and methods associated with recurrent MIPOL1-ETV1 genetic rearrangements that are useful for cancer diagnosis and therapy are disclosed.
摘要翻译： 公开了可用于癌症诊断和治疗的复发性MIPOL1-ETV1遗传重排相关的组合物和方法。
-
公开(公告)号：US10041123B2
公开(公告)日：2018-08-07
申请号：US11825552
申请日：2007-07-06
申请人： Arul M. Chinnaiyan , Scott Tomlins
发明人： Arul M. Chinnaiyan , Scott Tomlins
IPC分类号： C12Q1/68 , C12Q1/6886
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
摘要： Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
-
公开(公告)号：US20090208937A1
公开(公告)日：2009-08-20
申请号：US11825552
申请日：2007-07-06
申请人： Arul M. Chinnaiyan , Scott Tomlins
发明人： Arul M. Chinnaiyan , Scott Tomlins
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
摘要： Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
摘要翻译： 描述了雄激素调节基因或持家基因和ETS家族成员基因在前列腺癌中的复发性基因融合。 还提供了在前列腺癌诊断，研究和治疗中具有效用的组合物和方法。
-
公开(公告)号：US08759301B2
公开(公告)日：2014-06-24
申请号：US13024491
申请日：2011-02-10
CPC分类号： C07K14/4702 , A61K38/00 , C07K7/06 , C07K14/82
摘要： The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to recurrent gene fusions as clinical targets for prostate cancer.
摘要翻译： 本发明涉及用于癌症治疗的组合物和方法，包括但不限于癌症标志物的靶向抑制。 特别地，本发明涉及作为前列腺癌的临床靶标的复发性基因融合体。
-
公开(公告)号：US20110207198A1
公开(公告)日：2011-08-25
申请号：US13025290
申请日：2011-02-11
申请人： Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao , Irfan Asangani
发明人： Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao , Irfan Asangani
IPC分类号： C12N5/09 , C07H21/00 , C12N9/99 , C07K16/00 , C07D241/44
CPC分类号： C07D241/44 , C12N5/0693 , C12N2501/70
摘要： The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity.
摘要翻译： 本发明涉及可用于治疗，管理和/或研究癌症的药剂。 特别地，本发明涉及影响MMSET表达或活性的试剂（例如小分子，核酸）。
-
公开(公告)号：US07700293B2
公开(公告)日：2010-04-20
申请号：US11924415
申请日：2007-10-25
申请人： Arul M. Chinnaiyan
发明人： Arul M. Chinnaiyan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/5044 , G01N33/57434 , G01N2500/10
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与前列腺癌相关的基因表达谱。 使用本发明的方法鉴定为癌症标志物的基因可用于前列腺癌的诊断和表征。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。
-
公开(公告)号：US20130189679A1
公开(公告)日：2013-07-25
申请号：US13720411
申请日：2012-12-19
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12Q2600/156 , C12Q2600/158 , C12Y306/03001 , G01N33/57415 , G01N33/57434
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to pseudogenes as diagnostic markers and clinical targets for prostate cancer.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及作为前列腺癌的诊断标记物和临床靶标的假基因。
-
公开(公告)号：US20130096021A1
公开(公告)日：2013-04-18
申请号：US13629188
申请日：2012-09-27
CPC分类号： C12Q1/6886 , C07K16/32 , C12Q2600/156 , G01N33/57415
摘要： The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for breast cancer.
摘要翻译： 本公开涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本公开涉及作为乳腺癌的诊断标记物和临床靶标的基因融合体。
-
-
-
-
-
-
-
-
-
搜索结果
49 条记录 (耗时 0.038 秒)
