-
公开(公告)号：US20110206697A1
公开(公告)日：2011-08-25
申请号：US13023694
申请日：2011-02-09
申请人： Arul M. Chinnaiyan , Bushra Ateeq , Scott Tomlins
发明人： Arul M. Chinnaiyan , Bushra Ateeq , Scott Tomlins
IPC分类号： A61K39/395 , C12N5/071 , C12N5/09 , A61P35/00 , C07K16/18
CPC分类号： C07K16/38 , A61K2039/505 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to SPINK1 as a clinical target for prostate cancer.
摘要翻译： 本发明涉及用于癌症治疗的组合物和方法，包括但不限于癌症标志物的靶向抑制。 特别地，本发明涉及SPINK1作为前列腺癌的临床靶标。
-
公开(公告)号：US09303291B2
公开(公告)日：2016-04-05
申请号：US12667819
申请日：2008-07-03
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要： Compositions and methods associated with recurrent MIPOL1-ETV1 genetic rearrangements that are useful for cancer diagnosis and therapy are disclosed.
摘要翻译： 公开了可用于癌症诊断和治疗的复发性MIPOL1-ETV1遗传重排相关的组合物和方法。
-
公开(公告)号：US10041123B2
公开(公告)日：2018-08-07
申请号：US11825552
申请日：2007-07-06
申请人： Arul M. Chinnaiyan , Scott Tomlins
发明人： Arul M. Chinnaiyan , Scott Tomlins
IPC分类号： C12Q1/68 , C12Q1/6886
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
摘要： Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
-
公开(公告)号：US20110028336A1
公开(公告)日：2011-02-03
申请号：US12667819
申请日：2008-07-03
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要： Compositions and methods associated with recurrent MIPOL1-ETV1 genetic rearrangements that are useful for cancer diagnosis and therapy are disclosed.
摘要翻译： 公开了可用于癌症诊断和治疗的复发性MIPOL1-ETV1遗传重排相关的组合物和方法。
-
公开(公告)号：US20090208937A1
公开(公告)日：2009-08-20
申请号：US11825552
申请日：2007-07-06
申请人： Arul M. Chinnaiyan , Scott Tomlins
发明人： Arul M. Chinnaiyan , Scott Tomlins
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
摘要： Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
摘要翻译： 描述了雄激素调节基因或持家基因和ETS家族成员基因在前列腺癌中的复发性基因融合。 还提供了在前列腺癌诊断，研究和治疗中具有效用的组合物和方法。
-
公开(公告)号：US20110034677A1
公开(公告)日：2011-02-10
申请号：US12650164
申请日：2009-12-30
申请人： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
发明人： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
摘要： Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
摘要翻译： 描述了前列腺癌中雄激素调节基因和ETS家族成员基因的复发基因融合。 还提供了在前列腺癌诊断，研究和治疗中具有效用的组合物和方法。
-
公开(公告)号：US20130040858A1
公开(公告)日：2013-02-14
申请号：US13483157
申请日：2012-05-30
申请人： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
发明人： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
摘要： Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
摘要翻译： 描述了前列腺癌中雄激素调节基因和ETS家族成员基因的复发基因融合。 还提供了在前列腺癌诊断，研究和治疗中具有效用的组合物和方法。
-
公开(公告)号：US20100257617A1
公开(公告)日：2010-10-07
申请号：US11708858
申请日：2007-02-21
申请人： Chinnaiyan Arul , Bharathi Laxman , Scott Tomlins , Rohit Mera
发明人： Chinnaiyan Arul , Bharathi Laxman , Scott Tomlins , Rohit Mera
IPC分类号： A01K67/027
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusion nucleic acids and transgenic animals comprising recurrent gene fusion nucleic acids.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及复发性基因融合核酸和包含复发性基因融合核酸的转基因动物。
-
公开(公告)号：US08580509B2
公开(公告)日：2013-11-12
申请号：US13483176
申请日：2012-05-30
申请人： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
发明人： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
摘要： Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
-
公开(公告)号：US20100279301A1
公开(公告)日：2010-11-04
申请号：US12772429
申请日：2010-05-03
申请人： Arul Chinnaiyan , Rou Wang , David Morris , Scott Tomlins
发明人： Arul Chinnaiyan , Rou Wang , David Morris , Scott Tomlins
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to genes and gene panels as diagnostic markers and clinical targets for bladder cancer. Methods, compositions, and kits for diagnosing, determining, and determining risk of tumor aggressiveness are disclosed.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及基因和基因片段作为膀胱癌的诊断标志物和临床靶标。 公开了用于诊断，确定和确定肿瘤侵袭性的风险的方法，组合物和试剂盒。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.033 秒)
