Use of ph-responsive polymers
    3.
    发明申请
    Use of ph-responsive polymers 审中-公开
    ph反应聚合物的使用

    公开(公告)号:US20060189795A1

    公开(公告)日:2006-08-24

    申请号:US10547568

    申请日:2004-03-18

    IPC分类号: C07K14/47 B01J20/22

    摘要: The present invention relates to a method of isolating target compounds from a liquid, which comprises at a first pH, contacting the liquid with a separation medium that exhibits surface-localised pH-responsive polymers in to adsorb the target compound via hydrophobic interactions; and adding an eluent, which is of a second pH and provides a conformational change of said pH-responsive polymers to release said compounds. The elution is advantageously performed by a pH gradient and/or by a salt gradient.

    摘要翻译: 本发明涉及一种从液体中分离目标化合物的方法,该方法包括在第一pH下,使液体与分离介质接触,所述分离介质显示表面定位的pH响应性聚合物以通过疏水相互作用吸附目标化合物; 并加入洗脱液,其为第二pH,并提供所述pH响应聚合物的构象变化以释放所述化合物。 洗脱有利地通过pH梯度和/或盐梯度进行。