公开(公告)号：US20030008021A1

公开(公告)日：2003-01-09

申请号：US09885721

申请日：2001-06-20

申请人： ASHNI NATURACEUTICALS, INC.

发明人： John G. Babish ,  M. Terrence Howell

IPC分类号： A61K035/78 ,  A61K031/19 ,  A61K031/12 ,  A61K031/045 ,  A61K031/01 ,  A61K031/015

CPC分类号： A61K31/00 ,  A23L33/10 ,  A61K31/12 ,  A61K45/06 ,  A61K2300/00

摘要： A novel formulation is provided that serves to specifically inhibit the COX-2 mediated inflammatory response in animals. The formulation comprises comprising an effective amount of component I selected from the group consisting of alpha acids and beta acids and an effective amount of at least one component II selected from the group consisting of alpha acids, beta acids, essential oils, fats and waxes, with the proviso that component I and II are not the same compound. The composition provides specific inhibition of cyclooxygenase-2 with little or no effect on cyclooxygenase-1.

摘要翻译： 提供了用于特异性抑制动物中COX-2介导的炎性反应的新型制剂。 该制剂包含有效量的选自α酸和β酸的组分I和有效量的至少一种选自α酸，β酸，精油，脂肪和蜡的组分II， 条件是组分I和II不是相同的化合物。 该组合物对环加氧酶-2的特异性抑制作用，对环氧合酶-1几乎没有或没有影响。

公开(公告)号：US20020077350A1

公开(公告)日：2002-06-20

申请号：US09919510

申请日：2001-07-31

申请人： Ashni Naturaceuticals, Inc.

发明人： John G. Babish ,  Terrence Howell ,  Linda Pacioretty

IPC分类号： A61K031/365 ,  A61K031/366

CPC分类号： A61K31/19 ,  A61K31/34 ,  A61K2300/00

摘要： A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component, a diterpene triepoxide lactone species or a sesquiterpene lactone species and, as a second component, at least one member selected from the group consisting of a diterpene triepoxide lactone species, a sesquiterpene lactone species, a diterpene lactone species, and a triterpene species or derivatives thereof with the proviso that the same first component cannot also serve as the second component., and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.

摘要翻译： 提供了一种用于抑制动物炎症反应的新型制剂。 该制剂包含作为第一组分的二萜三环内酯种类或倍半萜内酯物质，并且作为第二组分，选自至少一种选自二萜三环内酯类，倍半萜内酯类，二萜内酯 物种和三萜类物质或其衍生物，条件是相同的第一成分也不能用作第二成分，并且响应于由生物制剂引起的身体或化学损伤或异常免疫刺激提供协同的抗炎作用或 未知病因。

公开(公告)号：US20020120001A1

公开(公告)日：2002-08-29

申请号：US09976670

申请日：2001-10-11

申请人： Ashni Naturaceuticals, Inc.

发明人： John G. Babish ,  Terrence Howell

IPC分类号： A61K038/05 ,  A61K031/70 ,  A61K031/404 ,  A61K031/355 ,  A61K031/198 ,  A61K031/015

CPC分类号： A61K45/06 ,  A61K31/015 ,  A61K31/355 ,  A61K31/404 ,  A61K2300/00

摘要： A novel formulation is provided that serves to synergistically inhibit the generation of free radicals and oxidative stress in warm blooded animals. The formulation comprises an effective amount of a first component of a tryptamine species or derivatives thereof, and, as a second component, at least one member selected from the group consisting of a carotenoid species, a tocotrienol species and derivatives thereof, and provides for synergistic anti-oxidant activity.

摘要翻译： 提供了一种新颖的配方，其用于协同地抑制温血动物中的自由基和氧化应激的产生。 该制剂包含有效量的色胺类物质或其衍生物的第一组分，作为第二组分，选自类胡萝卜素类，生育三烯酚类及其衍生物中的至少一种，并提供协同作用 抗氧化活性。

公开(公告)号：US20020110604A1

公开(公告)日：2002-08-15

申请号：US09925632

申请日：2001-08-09

申请人： Ashni Naturaceuticals, Inc.

发明人： John G. Babish ,  Terrence Howell

IPC分类号： A61K038/06 ,  A61K031/726 ,  A61K031/7048 ,  A61K031/704 ,  A61K031/7008 ,  A61K031/185 ,  A61K031/385

CPC分类号： A61K45/06

摘要： A novel formulation is provided that serves to synergistically inhibit the generation of free radicals and oxidative stress in animals. The formulation comprises as a first component a carotenoid species, and, as a second component, at least one member selected from the group consisting of lipoic acid, dihydrolipoic acid (DHLA), a stilbene species, ergothioneine, a flavone species, a triterpene species, ascorbic acid and derivatives thereof.

摘要翻译： 提供了一种新颖的配方，用于协同地抑制动物中自由基的产生和氧化应激。 该制剂包含作为第一组分的类胡萝卜素物质，并且作为第二组分，选自硫辛酸，二氢硫辛酸（DHLA），芪类，麦角硫素，黄酮类，三萜类物质中的至少一种 ，抗坏血酸及其衍生物。

公开(公告)号：US20020076452A1

公开(公告)日：2002-06-20

申请号：US09919506

申请日：2001-07-31

申请人： Ashni Naturaceuticals, Inc.

发明人： John G. Babish ,  Terrence Howell ,  Linda Pacioretty

IPC分类号： A61K038/06 ,  A61K035/78 ,  A61K031/737 ,  A61K031/704 ,  A61K031/7016 ,  A61K031/7008 ,  A61K031/365

CPC分类号： A61K45/06 ,  A61K31/7008 ,  A61K31/7016 ,  A61K31/7048 ,  A61K31/737 ,  A61K36/00 ,  A61K36/28 ,  A61K36/37 ,  A61K2300/00

摘要： A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a sesquiterpene lactone species and an effective amount of a second component selected from the group consisting of a diterpene lactone species and a triterpene species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.

摘要翻译： 提供了一种用于抑制动物炎症反应的新型制剂。 该制剂作为第一组分包含有效量的倍半萜内酯物质和有效量的选自二萜内酯物质和三萜烯物质或其衍生物的第二成分，并且提供协同的抗炎作用 由于生物制剂或未知病因引起的身体或化学损伤或免疫刺激异常的反应。

公开(公告)号：US20020068098A1

公开(公告)日：2002-06-06

申请号：US09920339

申请日：2001-08-01

申请人： Ashni Naturaceuticals, Inc.

发明人： John G. Babish ,  Terrence Howell ,  Linda Pacioretty

IPC分类号： A61K035/78 ,  A61K031/335 ,  A61K038/06 ,  A61K031/737 ,  A61K031/7008

CPC分类号： A61K31/365 ,  A61K47/54 ,  Y10S514/825 ,  Y10S514/885 ,  Y10S514/886 ,  A61K31/34 ,  A61K2300/00

摘要： A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone species and an effective amount of a second component selected from the group consisting of a diterpene lactone species and a triterpene species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.

摘要翻译： 提供了一种用于抑制动物炎症反应的新型制剂。 该制剂包含作为第一组分的有效量的二萜三环内酯物质和有效量的选自二萜内酯物质和三萜类物质或其衍生物的第二组分，并提供协同的抗炎作用 响应于由于生物制剂或未知病因引起的身体或化学损伤或异常免疫刺激。