公开(公告)号：US07060791B2

公开(公告)日：2006-06-13

申请号：US09983531

申请日：2001-10-24

申请人： Atsuko Fujisawa ,  Toru Yamakawa ,  Kamon Shirakawa ,  Chitose Orii ,  Naoki Ogawa

发明人： Atsuko Fujisawa ,  Toru Yamakawa ,  Kamon Shirakawa ,  Chitose Orii ,  Naoki Ogawa

IPC分类号： A61K38/04

CPC分类号： C12N9/6489 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/40 ,  C07K2317/76

摘要： The purpose of the present invention is to provide a novel protein involved in adhesion and fusion between myoblasts in the course of the formation of byotube. The present invention relates to Meltrins, which a membrane protein having fusion, adhesion and aggregation activity of cells, especially myoblast; and to polypeptides of their domains, DNAs encoding them, antisense RNA for these DNAs, various antibodies to Meltrins and the polypeptides of their domains, expression vectors containing these DNAs, and transformants by these vectors; as well as to the process for producing Meltrins and the polypeptides of their domains using those transformants and medical compositions comprising Meltrins or antagonist against them as an effective ingredient.

公开(公告)号：US20060247164A1

公开(公告)日：2006-11-02

申请号：US11276738

申请日：2006-03-13

申请人： Atsuko Fujisawa ,  Toru Yamakawa ,  Kamon Shirakawa ,  Chitose Orii ,  Naoki Ogawa

发明人： Atsuko Fujisawa ,  Toru Yamakawa ,  Kamon Shirakawa ,  Chitose Orii ,  Naoki Ogawa

IPC分类号： A61K38/17 ,  C07K14/705 ,  C07K16/18

CPC分类号： C12N9/6489 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/40 ,  C07K2317/76

摘要： The purpose of the present invention is to provide a novel protein involved in adhesion and fusion between myoblasts in the course of the formation of byotube. The present invention relates to Meltrins, which a membrane protein having fusion, adhesion and aggregation activity of cells, especially myoblast; and to polypeptides of their domains, DNAs encoding them, antisense RNA for these DNAs, various antibodies to Meltrins and the polypeptides of their domains, expression vectors containing these DNAs, and transformants by these vectors; as well as to the process for producing Meltrins and the polypeptides of their domains using those transformants and medical compositions comprising Meltrins or antagonist against them as an effective ingredient.

摘要翻译： 本发明的目的是提供一种新颖的蛋白质，其涉及在成骨细胞形成过程中成肌细胞之间的粘附和融合。 本发明涉及一种蛋白质，其具有细胞，特别是成肌细胞的融合，粘附和聚集活性的膜蛋白; 和其结构域的多肽，编码它们的DNA，这些DNA的反义RNA，对于Meltrins的各种抗体及其结构域的多肽，含有这些DNA的表达载体和通过这些载体的转化体; 以及使用这些转化体和包含Meltrins或其拮抗剂的药物组合物作为有效成分来生产Meltrins及其结构域的多肽的方法。

公开(公告)号：US07605226B2

公开(公告)日：2009-10-20

申请号：US11276738

申请日：2006-03-13

申请人： Atsuko Fujisawa ,  Toru Yamakawa ,  Kamon Shirakawa ,  Chitose Orii ,  Naoki Ogawa

发明人： Atsuko Fujisawa ,  Toru Yamakawa ,  Kamon Shirakawa ,  Chitose Orii ,  Naoki Ogawa

IPC分类号： A61K38/04 ,  A07K14/00

CPC分类号： C12N9/6489 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/40 ,  C07K2317/76

摘要： The purpose of the present invention is to provide a novel protein involved in adhesion and fusion between myoblasts in the course of the formation of byotube. The present invention relates to Meltrins, which a membrane protein having fusion, adhesion and aggregation activity of cells, especially myoblast; and to polypeptides of their domains, DNAs encoding them, antisense RNA for these DNAs, various antibodies to Meltrins and the polypeptides of their domains, expression vectors containing these DNAs, and transformants by these vectors; as well as to the process for producing Meltrins and the polypeptides of their domains using those transformants and medical compositions comprising Meltrins or antagonist against them as an effective ingredient.

公开(公告)号：US20070025992A1

公开(公告)日：2007-02-01

申请号：US10564745

申请日：2004-07-20

申请人： Hiroshi Takayama ,  Kamon Shirakawa ,  Toru Yamakawa ,  Tetsushi Kawahara

发明人： Hiroshi Takayama ,  Kamon Shirakawa ,  Toru Yamakawa ,  Tetsushi Kawahara

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/18 ,  C12N5/06

CPC分类号： C07K16/2803 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： The present invention provides a human antibody or an active-fragment thereof that specifically binds to human platelet membrane glycoprotein VI and does not induce a human platelet aggregation independently; a cell that produces the antibody or its active-fragment; a pharmaceutical composition that comprises the antibody or its active-fragment as an active ingredient, and so on. The above-mentioned cell can be obtained for example, as follows: a peripheral-blood-lymphocyte of the human that produces an autologous antibody to GPVI is activated by in vitro immunization under specific conditions; a hybridoma with mouse myeloma cell is prepared; and then the hybridoma that produces a monoclonal antibody, which has a binding capacity to GPVI and has an activity that suppresses collagen-mediated agglutinability of the human platelet is selected.

摘要翻译： 本发明提供了特异性结合人血小板膜糖蛋白VI并且不独立诱导人血小板聚集的人抗体或其活性片段， 产生抗体或其活性片段的细胞; 包含抗体或其活性片段作为活性成分的药物组合物等。 上述细胞可以例如如下获得：产生GPVI自体抗体的人的外周血淋巴细胞通过在特定条件下的体外免疫而被活化; 制备具有小鼠骨髓瘤细胞的杂交瘤; 然后选择产生具有GPVI结合能力并具有抑制人血小板的胶原介导的凝集能力的活性的单克隆抗体的杂交瘤。

公开(公告)号：US20050018047A1

公开(公告)日：2005-01-27

申请号：US10864117

申请日：2004-06-09

申请人： Toru Yamakawa

发明人： Toru Yamakawa

IPC分类号： H04N17/04 ,  G09G1/28 ,  H01J29/51 ,  H04N17/02

CPC分类号： H04N17/04

摘要： Information about various adjustments made to TVs during assembly is entered into a database after each adjustment, to facilitate monitoring and reporting of the assembly process, so that corrective action when appropriate can be taken more quickly.

摘要翻译： 关于在组装过程中对电视机进行各种调整的信息在每次调整后输入数据库，以便于组装过程的监控和报告，从而可以更快地采取适当的纠正措施。

公开(公告)号：US4560021A

公开(公告)日：1985-12-24

申请号：US491329

申请日：1983-04-08

申请人： Toru Yamakawa

发明人： Toru Yamakawa

IPC分类号： F02D25/04 ,  B60K23/00 ,  B60K25/00 ,  B60W10/02 ,  B60W10/06 ,  F02D25/00 ,  B60K5/08

CPC分类号： B60W30/18 ,  B60W10/02 ,  B60W10/04 ,  B60W10/06 ,  B60W30/1819 ,  F02D25/00 ,  B60K5/08

摘要： A control system having a plurality of sensors which sense conditions of a vehicle for producing signals, a selection button which selects combinations of the sensed signals and a control device which operates in response to the selected combination of signals to control a clutch to incorporate a plurality of engine units and the output engine torque.

摘要翻译： PCT No.PCT / JP82 / 00359 Sec。 371日期：1983年4月8日 102（e）日期1983年4月8日PCT提交1982年9月8日PCT公布。 第WO83 / 00847号公报 日期：1983年3月17日。一种控制系统，具有检测用于产生信号的车辆的状态的多个传感器，选择感测信号的组合的选择按钮和响应所选择的信号组合而操作的控制装置 控制离合器以并入多个发动机单元和输出发动机扭矩。

公开(公告)号：US4662490A

公开(公告)日：1987-05-05

申请号：US485580

申请日：1983-03-21

申请人： Toru Yamakawa

发明人： Toru Yamakawa

IPC分类号： F16H37/06 ,  B60K5/08 ,  F02B73/00 ,  F16D25/12 ,  B60K41/02 ,  F01B21/02

CPC分类号： F02B73/00 ,  B60K5/08 ,  Y10T477/27 ,  Y10T477/6425 ,  Y10T74/19014

摘要： A system for controlling a clutch for a plurality of independent engine units, in which gears of the engine units are engaged with a gear of an output shaft and are arranged to form a pump chamber, the output fluid of the pump chamber being used for operating the clutch so as to connect engine units with each other.

摘要翻译： PCT No.PCT / JP82 / 00358 Sec。 371日期1983年3月21日 102（e）1983年3月21日PCT PCT。1982年9月8日PCT公布。 出版物WO83 / 00906 日期：1983年3月17日。一种用于控制多个独立发动机单元的离合器的系统，其中发动机单元的齿轮与输出轴的齿轮接合并且被布置成形成泵室，输出流体 泵室用于操作离合器，以将发动机单元彼此连接。

公开(公告)号：US4430862A

公开(公告)日：1984-02-14

申请号：US294687

申请日：1981-08-20

申请人： Toru Yamakawa

发明人： Toru Yamakawa

IPC分类号： F02B73/00 ,  F02D25/04 ,  F02M13/02

CPC分类号： F02B73/00 ,  F02D25/04 ,  F02M13/023

摘要： An internal combustion engine for vehicles comprising a primary and an auxiliary engine unit each comprising vertically disposed cylinders and a crankshaft operatively connected to the respective cylinders. The crankshafts are arranged in parallel. A first output shaft is positioned parallel to both crankshafts and at an intermediate position between extensions of the crankshafts. The auxiliary engine unit is spaced apart from an end of the output shaft defining a space. The cylinders of each engine unit are arranged in staggered disposition. A clutch is disposed in the space between the auxiliary engine unit and the output shaft for transmitting an output of the auxiliary engine unit to the output shaft. A gear train comprises three gears including a first end gear secured to the crankshaft of the primary engine unit, a second end gear secured to an output shaft of the clutch, and an intermediate gear secured to the first output shaft engaging with both end gears. A switch provides for engaging the clutch when engine load exceeds a predetermined value.

摘要翻译： 一种用于车辆的内燃机，包括主和辅助发动机单元，每个发动机单元包括垂直设置的气缸和可操作地连接到相应气缸的曲轴。 曲轴平行排列。 第一输出轴平行于两个曲轴定位并且在曲轴的延伸部之间的中间位置。 辅助发动机单元与限定空间的输出轴的端部间隔开。 每个发动机单元的气缸以交错的配置布置。 在辅助发动机单元和输出轴之间的空间中设置有离合器，用于将辅助发动机单元的输出传递到输出轴。 齿轮系包括三个齿轮，包括固定到主发动机单元的曲轴的第一端齿轮，固定到离合器的输出轴的第二端齿轮，以及固定到与两个端齿轮啮合的第一输出轴的中间齿轮。 当发动机负载超过预定值时，开关用于接合离合器。

公开(公告)号：US4897752A

公开(公告)日：1990-01-30

申请号：US147515

申请日：1988-01-25

申请人： Hajime Doi ,  Toru Yamakawa ,  Fujio Matsumoto ,  Kunio Mizushima

发明人： Hajime Doi ,  Toru Yamakawa ,  Fujio Matsumoto ,  Kunio Mizushima

IPC分类号： G11B23/03 ,  G11B23/00 ,  G11B23/033 ,  G11B23/50

CPC分类号： G11B23/505 ,  G11B23/0332

摘要： A disk cartridge which comprises a cartridge case, a disk rotatably encased in the cartridge case, and a cleaning sheet supported on the inside surface of the cartridge case by welding, the cartridge case being composed of a thermoplastic synthetic resin, and the cleaning sheet being composed at least of a mixed fabric of acrylic fibers and rayon fibers and being fixed to the inside surfaces of the cartridge case by welding has distinguished disk-handling characteristics and cartridge case-fixing characteristics.

摘要翻译： 一种盘盒，其包括盒壳体，可旋转地包围在盒壳体中的盘，以及通过焊接而被支撑在盒壳体的内表面上的清洁片，所述盒壳体由热塑性合成树脂构成，并且所述清洁片材为 至少由丙烯酸纤维和人造纤维的混合织物组成并且通过焊接固定到盒壳体的内表面具有突出的盘处理特性和盒壳固定特性。

公开(公告)号：US4576061A

公开(公告)日：1986-03-18

申请号：US561719

申请日：1983-12-15

申请人： Toru Yamakawa ,  Fujio Makita ,  Mitsuo Umezawa ,  Ryuzo Sakakiyama

发明人： Toru Yamakawa ,  Fujio Makita ,  Mitsuo Umezawa ,  Ryuzo Sakakiyama

IPC分类号： B60K23/08 ,  F16H37/06

CPC分类号： B60K23/08 ,  Y10T477/613 ,  Y10T74/19084

摘要： A system for controlling a power transmission of a four-wheel drive vehicle powered by an engine. The system is provided with a transmission for transmitting a power of the engine to main wheels, a clutch for selectively transmitting the power to auxiliary wheels, a vehicle speed sensor for sensing the speed of the vehicle and for producing a vehicle speed signal dependent on the speed, a steering angle sensor for sensing the steering angle of the vehicle and for producing a steering angle signal dependent on the steering angle. A control circuit is provided to compare the vehicle speed signal and steering angle signal with reference values and judge whether the condition is in the range of conditions causing tight corner braking and to produce a clutch signal. A switch is responsive to the clutch signal for disengaging the clutch, whereby the four-wheel drive is changed to the two-wheel drive.

摘要翻译： 一种用于控制由发动机驱动的四轮驱动车辆的动力传递的系统。 该系统设置有用于将发动机的动力传递到主轮的变速器，用于选择性地将动力传递到辅助车轮的离合器，用于感测车辆速度的车速传感器以及用于产生取决于车辆速度的车速信号 速度，用于感测车辆的转向角的转向角传感器，以及用于产生取决于转向角的转向角信号。 提供控制电路以将车速信号和转向角信号与参考值进行比较，并判断条件是否在导致紧弯角制动的条件范围内并产生离合器信号。 开关响应于离合器信号以分离离合器，由此将四轮驱动改变为两轮驱动。