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11 条记录 (耗时 0.026 秒)

    Retinoid receptor compositions and methods
    4.
    发明授权
    Retinoid receptor compositions and methods 失效
    类视黄醇受体组合物和方法

    公开(公告)号：US07501487B1

    公开(公告)日：2009-03-10

    申请号：US08467543

    申请日：1995-06-05

    申请人： David J. Mangelsdorf ,  Ronald M. Evans

    发明人： David J. Mangelsdorf ,  Ronald M. Evans

    IPC分类号： A07K14/00

    CPC分类号： C07K14/70567 ,  C12N15/64 ,  C12N15/67 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/002

    摘要： The present invention relates to novel receptor polypeptides, which, upon interaction with certain ligands, or activation by certain compounds, modulate transcription of certain genes by binding to cognate response elements associated with promoters of such genes. The novel receptors of the invention modulate transcription in the presence of retinoid compounds.The receptors of the present invention differ significantly from known retinoic acid receptors, in protein primary sequence and in responsiveness to exposure to various retinoids.The invention provides DNAs encoding the novel receptors, expression vectors for expression of the receptors, cells transformed with such expression vectors, cells co-transformed with such expression vectors and with reporter vectors to monitor modulation of transcription by the receptors, and methods of using such co-transformed cells in screening for compounds which are capable, directly or indirectly, of activating the receptors.The invention also provides nucleic acid probes for identifying DNAs which encode additional retinoid receptors of the same class as the novel receptors disclosed herein.

    摘要翻译： 本发明涉及新的受体多肽，其在与某些配体相互作用或某些化合物的活化时，通过结合与这些基因的启动子相关的同源反应元件来调节某些基因的转录。 本发明的新受体在类视色素化合物存在下调节转录。 本发明的受体与已知的视黄酸受体显着不同，蛋白质一级序列和对各种类视黄醇的暴露反应。 本发明提供了编码新受体的DNA，用于表达受体的表达载体，用这种表达载体转化的细胞，用这些表达载体共转化的细胞和用报道载体监测受体转录的调节的方法 共转化细胞筛选能够直接或间接激活受体的化合物。 本发明还提供用于鉴定编码与本文公开的新型受体相同类别的另外的类视黄醇受体的DNA的核酸探针。

    Antibodies against PRO1879 and the use thereof
    5.
    发明授权
    Antibodies against PRO1879 and the use thereof 有权
    PRO1879抗体及其用途

    公开(公告)号：US07357926B2

    公开(公告)日：2008-04-15

    申请号：US10125704

    申请日：2002-04-17

    申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Victoria Smith ,  William I. Wood

    发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Victoria Smith ,  William I. Wood

    IPC分类号： A61K39/395 ,  A07K14/00 ,  A01N33/53

    CPC分类号： C07K14/47

    摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

    Antibodies against PRO1310
    6.
    发明授权
    Antibodies against PRO1310 有权
    PRO1310抗体

    公开(公告)号：US07329404B2

    公开(公告)日：2008-02-12

    申请号：US10123910

    申请日：2002-04-16

    申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Victoria Smith ,  William I. Wood

    发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Victoria Smith ,  William I. Wood

    IPC分类号： A61K39/395 ,  A07K14/00 ,  A01N33/53

    CPC分类号： A61K39/395

    摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

    Protease for activating clotting factor VII
    7.
    发明授权
    Protease for activating clotting factor VII 有权
    用于激活凝血因子VII的蛋白酶

    公开(公告)号：US06911334B2

    公开(公告)日：2005-06-28

    申请号：US10319592

    申请日：2002-12-16

    申请人： Jürgen Römisch ,  Annette Feussner ,  Hans-Arnold Stöhr

    发明人： Jürgen Römisch ,  Annette Feussner ,  Hans-Arnold Stöhr

    IPC分类号： A61K38/46 ,  A61K38/00 ,  A61K38/48 ,  A61L15/38 ,  C07K14/745 ,  C12N9/64 ,  C12Q1/56 ,  G01N33/53 ,  G01N33/86 ,  C12N9/50 ,  A07K14/00

    CPC分类号： A61L15/38 ,  A61K38/00 ,  A61K38/57 ,  C07K14/745 ,  C12N9/6424 ,  C12Q1/56 ,  G01N33/86 ,  G01N2333/96447

    摘要： A protease for activating the blood clotting factor VII is described, wherein the protease is inhibited by the presence of aprotinin and is increased in its activity by calcium ions and/or heparin or heparin-related substances, and wherein in SDS-PAGE, on subsequent staining in the non-reduced state, the protease has one or more brands in the molecular weight range from 50 to 75 kDa, and in the reduced state, the protease has a band at 40 to 55 kDa and one or more bands in the molecular weight range from 10 to 35 kDa. The proenzyme of this protease is also characterized. Further, a process for obtaining this protease and its use in hemorrhage prophylaxis or hemostasis is described. Moreover, a test system for the qualitative and quantitative detection of a protease which activates the blood clotting factor VII is described.

    摘要翻译： 描述了用于激活血液凝固因子VII的蛋白酶，其中蛋白酶被抑肽酶抑制，并且其钙离子和/或肝素或肝素相关物质的活性增加，并且其中在SDS-PAGE中，随后 在非还原状态下染色，蛋白酶在50至75kDa的分子量范围内具有一个或多个品牌，并且在还原状态下，蛋白酶具有在40至55kDa的条带和分子中的一个或多个条带 重量范围为10至35kDa。 该蛋白酶的酶还具有特征。 此外，描述了获得该蛋白酶的方法及其在出血预防或止血中的用途。 此外，描述了用于定性和定量检测激活凝血因子VII的蛋白酶的测试系统。

    S-nitrosoprotein preparation and production method therefor
    8.
    发明授权
    S-nitrosoprotein preparation and production method therefor 有权
    S-亚硝基蛋白的制备及其制备方法

    公开(公告)号：US07803759B2

    公开(公告)日：2010-09-28

    申请号：US11890542

    申请日：2007-08-07

    申请人： Yu Ishima ,  Takaaki Akaike ,  Masaki Otagiri

    发明人： Yu Ishima ,  Takaaki Akaike ,  Masaki Otagiri

    IPC分类号： A61K38/00 ,  A07K14/00

    CPC分类号： C07K1/1077 ,  A61K38/00 ,  C07K14/76

    摘要： A protein is efficiently nitrosylated with nitrogen monoxide by merely mixing S-nitrosoglutathione as a nitrogen monoxide donor with a protein solution containing a stabilizing agent comprising at least one compound or a combination of plural compounds selected from an N-acetylamino acid, a fatty acid, and a fatty acid salt. The method that enables efficient NO addition to a cysteine residue in un-nitrosylated protein without changing the structure of protein and hence provides NO to a living organism.

    摘要翻译： 通过仅将含有至少一种化合物或多种化合物的组合的蛋白质溶液与N-亚乙基氨基酸，脂肪酸， 和脂肪酸盐。 能够在不改变蛋白质结构的情况下对非亚硝基化蛋白质中的半胱氨酸残基进行高效NO添加，从而为活体提供NO的方法。

    Method of producing S-nitrosoprotein preparation
    9.
    发明授权
    Method of producing S-nitrosoprotein preparation 失效
    生产S-亚硝基蛋白制备方法

    公开(公告)号：US07718607B2

    公开(公告)日：2010-05-18

    申请号：US12218059

    申请日：2008-07-11

    申请人： Yu Ishima ,  Takaaki Akaike ,  Masaki Otagiri

    发明人： Yu Ishima ,  Takaaki Akaike ,  Masaki Otagiri

    IPC分类号： A61K38/00 ,  A07K14/00

    CPC分类号： C07K1/1077 ,  A61K38/00 ,  C07K14/76

    摘要： A protein is efficiently nitrosylated with nitrogen monoxide by merely mixing S-nitrosoglutathione as a nitrogen monoxide donor with a protein solution containing a stabilizing agent comprising at least one compound or a combination of plural compounds selected from an N-acetylamino acid, a fatty acid, and a fatty acid salt. The method that enables efficient NO addition to a cysteine residue in un-nitrosylated protein without changing the structure of protein and hence provides NO to a living organism.

    摘要翻译： 通过仅将含有至少一种化合物或多种化合物的组合的蛋白质溶液与N-亚乙基氨基酸，脂肪酸， 和脂肪酸盐。 能够在不改变蛋白质结构的情况下对非亚硝基化蛋白质中的半胱氨酸残基进行高效NO添加，从而为活体提供NO的方法。