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公开(公告)号：US20070015264A1
公开(公告)日：2007-01-18
申请号：US11429049
申请日：2006-05-08
申请人： Atsushi Isotani , Hideo Ikeda , Kenji Yamagishi , Ryusuke Aoyama
发明人： Atsushi Isotani , Hideo Ikeda , Kenji Yamagishi , Ryusuke Aoyama
CPC分类号： C12P7/46 , Y02P20/582
摘要： Organic acid ammonium solution is produced by the steps of obtaining a fermentation broth containing organic acid magnesium by using an organic acid-producing microorganism in the presence of a magnesium compound, producing organic acid ammonium and a magnesium compound by subjecting the organic acid magnesium contained in the fermentation broth to salt-exchange using an ammonia compound, and separating the produced magnesium compound to obtain organic acid ammonium solution.
摘要翻译： 有机酸铵溶液是通过在镁化合物的存在下使用有机酸生成微生物获得含有机酸镁的发酵液，通过使含有有机酸镁的有机酸镁 使用氨化合物将发酵液发酵至盐交换，分离生成的镁化合物，得到有机酸铵溶液。
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2.发明申请公开(公告)号：US20090156779A1
公开(公告)日：2009-06-18
申请号：US12280426
申请日：2007-02-23
申请人： Makoto Murase , Ryusuke Aoyama , Akiko Sakamoto , Sanae Sato , Madoka Yonekura , Shuichi Yunomura , Kenji Yamagishi , Keita Fukui , Chie Koseki , Jun Nakamura , Hiroyuki Kojima
发明人： Makoto Murase , Ryusuke Aoyama , Akiko Sakamoto , Sanae Sato , Madoka Yonekura , Shuichi Yunomura , Kenji Yamagishi , Keita Fukui , Chie Koseki , Jun Nakamura , Hiroyuki Kojima
CPC分类号： C12P7/46
摘要： Provided is a bacterium which is capable of producing an organic acid and is modified so as to have an enhanced 2-oxoglutarate dehydrogenase activity as compared with that of an unmodified strain. An organic acid such as succinic acid can be produced by culturing the bacterium.
摘要翻译： 本发明提供一种能够产生有机酸的细菌，并且与未改变的菌株相比被改性以具有增强的2-氧戊二酸脱氢酶活性。 可以通过培养细菌来生产琥珀酸等有机酸。
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公开(公告)号：US07993888B2
公开(公告)日：2011-08-09
申请号：US12280426
申请日：2007-02-23
申请人： Makoto Murase , Ryusuke Aoyama , Akiko Sakamoto , Sanae Sato , Madoka Yonekura , Shuichi Yunomura , Kenji Yamagishi , Keita Fukui , Chie Koseki , Jun Nakamura , Hiroyuki Kojima
发明人： Makoto Murase , Ryusuke Aoyama , Akiko Sakamoto , Sanae Sato , Madoka Yonekura , Shuichi Yunomura , Kenji Yamagishi , Keita Fukui , Chie Koseki , Jun Nakamura , Hiroyuki Kojima
CPC分类号： C12P7/46
摘要： Provided is a bacterium which is capable of producing an organic acid and is modified so as to have an enhanced 2-oxoglutarate dehydrogenase activity as compared with that of an unmodified strain. An organic acid such as succinic acid can be produced by culturing the bacterium.
摘要翻译： 本发明提供一种能够产生有机酸的细菌，并且与未改变的菌株相比被改性以具有增强的2-氧戊二酸脱氢酶活性。 可以通过培养细菌来生产琥珀酸等有机酸。
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公开(公告)号：US20060205048A1
公开(公告)日：2006-09-14
申请号：US11362931
申请日：2006-02-28
申请人： Makoto Murase , Ryusuke Aoyama , Miki Ikuta , Kenji Yamagishi , Mika Moriya , Jun Nakamura , Hiroyuki Kojima
发明人： Makoto Murase , Ryusuke Aoyama , Miki Ikuta , Kenji Yamagishi , Mika Moriya , Jun Nakamura , Hiroyuki Kojima
CPC分类号： C12P7/46
摘要： Succinic acid is produced by allowing a bacterium modified to enhance fumarate reductase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to generate succinic acid. More preferably, succinic acid is produced by allowing a bacterium modified to enhance activities of fumarate reductase and pyruvate carboxylase and decrease lactate dehydrogenase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to generate succinic acid. Succinic acid is obtained by collecting the produced succinic acid.
摘要翻译： 琥珀酸是通过使经修饰的细菌增强富马酸盐还原酶活性或其制备方法与含有碳酸根离子，碳酸氢根离子和二氧化碳气体的反应溶液中的有机原料反应生成琥珀酸而制备的。 更优选地，通过使经修饰的细菌增强富马酸盐还原酶和丙酮酸羧化酶的活性并降低乳酸脱氢酶活性或其细胞制备，在含有碳酸根离子，碳酸氢盐 离子和二氧化碳气体产生琥珀酸。 通过收集产生的琥珀酸获得琥珀酸。
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5.发明授权Method of producing succinic acid with bacterium comprising a modified fumarate reductase gene or a modified succinate dehydrogenase gene 有权用包含改性的富马酸酯还原酶基因或修饰的琥珀酸脱氢酶基因的细菌生产琥珀酸的方法公开(公告)号：US07763447B2
公开(公告)日：2010-07-27
申请号：US11362931
申请日：2006-02-28
申请人： Makoto Murase , Ryusuke Aoyama , Miki Ikuta , Kenji Yamagishi , Mika Moriya , Jun Nakamura , Hiroyuki Kojima
发明人： Makoto Murase , Ryusuke Aoyama , Miki Ikuta , Kenji Yamagishi , Mika Moriya , Jun Nakamura , Hiroyuki Kojima
CPC分类号： C12P7/46
摘要： Succinic acid is produced by allowing a bacterium modified to enhance fumarate reductase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to generate succinic acid. More preferably, succinic acid is produced by allowing a bacterium modified to enhance activities of fumarate reductase and pyruvate carboxylase and decrease lactate dehydrogenase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to generate succinic acid. Succinic acid is obtained by collecting the produced succinic acid.
摘要翻译： 琥珀酸是通过使经修饰的细菌增强富马酸盐还原酶活性或其制备方法与含有碳酸根离子，碳酸氢根离子和二氧化碳气体的反应溶液中的有机原料反应生成琥珀酸而制备的。 更优选地，通过使经修饰的细菌增强富马酸盐还原酶和丙酮酸羧化酶的活性并降低乳酸脱氢酶活性或其细胞制备，在含有碳酸根离子，碳酸氢盐 离子和二氧化碳气体产生琥珀酸。 通过收集产生的琥珀酸获得琥珀酸。
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公开(公告)号：US07563606B2
公开(公告)日：2009-07-21
申请号：US11376133
申请日：2006-03-16
CPC分类号： C12P7/46
摘要： Non-amino organic acids such as succinic acid, malic acid and fumaric acid are produced by reacting bacterial cells or treated bacterial cells of a coryneform bacterium with an organic raw material in an aqueous medium containing magnesium carbonate and/or magnesium hydroxide, and a certain range of concentration of a monovalent cation, while maintaining the pH within a certain range without increasing the volume of the aqueous medium.
摘要翻译： 非氨基有机酸如琥珀酸，苹果酸和富马酸是通过将棒状细菌的细菌细胞或经处理的细菌细胞与有机原料反应在含有碳酸镁和/或氢氧化镁的水性介质中而产生的， 同时将pH保持在一定范围内，同时不增加水性介质的体积。
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公开(公告)号：US20060281156A1
公开(公告)日：2006-12-14
申请号：US11376133
申请日：2006-03-16
CPC分类号： C12P7/46
摘要： Non-amino organic acids such as succinic acid, malic acid and fumaric acid are produced by reacting bacterial cells or treated bacterial cells of a coryneform bacterium with an organic raw material in an aqueous medium containing magnesium carbonate and/or magnesium hydroxide, and a certain range of concentration of a monovalent cation, while maintaining the pH within a certain range without increasing the volume of the aqueous medium.
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