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公开(公告)号：US20220331259A1
公开(公告)日：2022-10-20
申请号：US17808162
申请日：2022-06-22
申请人： AUBURN UNIVERSITY , Altimmune, Inc.
发明人： Allan E. David , Henry J. Baker , Aime K. Johnson , M. Scot Roberts , Kent R. Van Kampen , Prachi Sangle
IPC分类号： A61K9/50 , A61K9/51 , A61K39/12 , A61P31/20 , A61P31/16 , A61K9/00 , A61K9/19 , A61K39/145 , A61K39/235
摘要： Therapeutic or prophylactic compositions providing an active agent, such as an antigen or a vector that contains and expresses an antigen, encapsulated in or incorporated into a biodegradable polymeric particle are provided. The compositions can also provide an active agent that is not encapsulated in or incorporated into the biodegradable polymeric particle in order to provide an initial or prime delivery of the active agent. Particles or composites providing an active agent encapsulated by a first and second polymer are also provided, wherein polymers are distributed in a gradient from a core of the composite to a surface of the composite, and configured to provide a delayed release of the active agent by a period of 7 days to 6 months. Methods of producing composites are also provided. Pharmaceutical formulations providing a single dose composition are also provided, along with methods for administering the pharmaceutical compositions to a subject in need thereof a therapeutically effective amount of an active agent are provided.
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2.发明申请公开(公告)号：US20180078507A1
公开(公告)日：2018-03-22
申请号：US15706335
申请日：2017-09-15
申请人： Auburn University , Altimmune, Inc.
发明人： Allan E. David , Henry J. Baker , Aime K. Johnson , M. Scot Roberts , Kent R. Van Kampen , Prachi Sangle
IPC分类号： A61K9/50 , A61K9/19 , A61K9/00 , A61K39/235 , A61K39/145
CPC分类号： A61K9/5036 , A61K9/0019 , A61K9/0095 , A61K9/19 , A61K9/5031 , A61K9/5153 , A61K39/12 , A61K39/145 , A61K39/235 , A61K2039/55555 , A61P31/16 , A61P31/20 , C12N2710/10034 , C12N2710/10343 , C12N2760/16034 , C12N2760/16071 , C12N2760/16134
摘要： Therapeutic or prophylactic compositions providing an active agent, such as an antigen or a vector that contains and expresses an antigen, encapsulated in or incorporated into a biodegradable polymeric particle are provided. The compositions can also provide an active agent that is not encapsulated in or incorporated into the biodegradable polymeric particle in order to provide an initial or prime delivery of the active agent. Particles or composites providing an active agent encapsulated by a first and second polymer are also provided, wherein polymers are distributed in a gradient from a core of the composite to a surface of the composite, and configured to provide a delayed release of the active agent by a period of 7 days to 6 months. Methods of producing composites are also provided. Pharmaceutical formulations providing a single dose composition are also provided, along with methods for administering the pharmaceutical compositions to a subject in need thereof a therapeutically effective amount of an active agent are provided.
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公开(公告)号：US20220072121A1
公开(公告)日：2022-03-10
申请号：US17342769
申请日：2021-06-09
申请人： Altimmune, Inc
IPC分类号： A61K39/215 , C12N15/86 , A61P31/14 , A61K9/00 , C12N7/00
摘要： CORONAVIRUS IMMUNOGENIC COMPOSITIONS AND USES THEREOF Provided in the present disclosure are immunogenic compounds, pharmaceutical formulations thereof and their use for inducing a protective immune response against 2019 novel coronavirus (SARS-CoV-2) infection and variants in a mammal.
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公开(公告)号：US20210260181A1
公开(公告)日：2021-08-26
申请号：US17175144
申请日：2021-02-12
申请人： Altimmune, Inc
IPC分类号： A61K39/215 , C12N15/86 , C12N7/00 , A61K9/00 , A61P31/14
摘要： Provided in the present disclosure are immunogenic compounds, pharmaceutical formulations thereof and their use for inducing a protective immune response against 2019 novel coronavirus (SARS-CoV-2) infection and variants in a mammal.
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公开(公告)号：US20220354943A1
公开(公告)日：2022-11-10
申请号：US17634990
申请日：2020-08-13
申请人： Altimmune, Inc
IPC分类号： A61K39/145 , A61K9/00 , A61K39/215 , A61K39/125 , A61K39/165 , A61K39/07 , A61K39/04 , A61K39/085 , A61K39/09 , A61K39/104 , A61K39/108 , A61K39/102 , A61K39/02 , A61K39/00 , A61K39/12 , A61P31/16 , A61P31/14
摘要： Disclosed herein are methods for generating a protective immunogenic response via intranasal administration of an immunogenic composition (e.g., vaccine)/therapeutic immunogenic composition in a mammalian subject. Certain dosing positions of the subject during the administration of immunogenic agents, such that nostrils are tilted upwards, while in a modified sitting, reclining and/or supine posture, is surprisingly correlated with the generation of a strong immunogenic response in both humans and animals.
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公开(公告)号：US11382968B2
公开(公告)日：2022-07-12
申请号：US17342769
申请日：2021-06-09
申请人： Altimmune, Inc
摘要： Provided in the present disclosure are immunogenic compounds, pharmaceutical formulations thereof and their use for inducing a protective immune response against 2019 novel coronavirus (SARS-CoV-2) infection and variants in a mammal.
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公开(公告)号：US20210260180A1
公开(公告)日：2021-08-26
申请号：US17175131
申请日：2021-02-12
申请人： Altimmune, Inc
IPC分类号： A61K39/215 , C12N7/00 , C12N15/86
摘要： Provided in the present disclosure are immunogenic compounds, pharmaceutical formulations thereof and their use for inducing a protective immune response against 2019 novel coronavirus (SARS-CoV-2) infection and variants in a mammal.
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