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公开(公告)号：US20240009031A1
公开(公告)日：2024-01-11
申请号：US18471950
申请日：2023-09-21
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Reza Zadno , Paul Bavier , David C. Iannetta , Jun Zhang
CPC classification number: A61N5/062 , A61F9/0017 , A61N2005/0626 , A61N2005/0652 , A61N2005/0648
Abstract: A micro-device for corneal cross-linking treatment includes a body including an outer portion and an inner portion. The inner portion is coupled to the outer portion which is disposed about a periphery of the inner portion. When the body is against an eye surface, the outer portion contacts the eye surface and the inner portion defines a chamber over a cornea of the eye. The micro-device includes an illumination system including a micro-optical element and an optical fiber. The micro-optical element includes micro-LEDs configured to direct photoactivating light through the inner portion to the cornea of the eye when the body is positioned against the surface of the eye. The photoactivating light generates cross-linking activity with a cross-linking agent applied to the cornea. The optical fiber couples the micro-optical element to a light source and includes a surface configured to reflect the photoactivating light to the micro-optical element.
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公开(公告)号：US11766356B2
公开(公告)日：2023-09-26
申请号：US16979088
申请日：2019-03-08
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Reza Zadno , Paul Bavier , David C. Iannetta , Jun Zhang
IPC: A61F9/008
CPC classification number: A61F9/008 , A61F2009/00872
Abstract: A micro-device for corneal cross-linking treatment includes a body including an outer portion and an inner portion. The outer portion is disposed about a periphery of the inner portion. The inner portion is shaped such that, when the body is positioned against a surface of an eye, the outer portion contacts the surface of the eye and the inner portion defines a chamber over a cornea of the eye. The micro-device includes an illumination system including a micro-optical element coupled to the body. The micro-optical element is configured to direct photoactivating light to the cornea of the eye when the body is positioned against the surface of the eye. The photoactivating light generates cross-linking activity with a cross-linking agent applied to the cornea.
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3.发明申请公开(公告)号：US20200229692A1
公开(公告)日：2020-07-23
申请号：US16840317
申请日：2020-04-03
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20180206719A1
公开(公告)日：2018-07-26
申请号：US15868457
申请日：2018-01-11
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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公开(公告)号：US11529050B2
公开(公告)日：2022-12-20
申请号：US16840317
申请日：2020-04-03
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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公开(公告)号：US20210000646A1
公开(公告)日：2021-01-07
申请号：US16979088
申请日：2019-03-08
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Reza Zadno , Paul Bavier , David C. Iannetta , Jun Zhang
IPC: A61F9/008
Abstract: A micro-device for corneal cross-linking treatment includes a body including an outer portion and an inner portion. The outer portion is disposed about a periphery of the inner portion. The inner portion is shaped such that, when the body is positioned against a surface of an eye, the outer portion contacts the surface of the eye and the inner portion defines a chamber over a cornea of the eye. The micro-device includes an illumination system including a micro-optical element coupled to the body. The micro-optical element is configured to direct photoactivating light to the cornea of the eye when the body is positioned against the surface of the eye. The photoactivating light generates cross-linking activity with a cross-linking agent applied to the cornea.
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7.发明公开公开(公告)号：US20240335108A1
公开(公告)日：2024-10-10
申请号：US18738229
申请日：2024-06-10
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun A. Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
CPC classification number: A61B3/107 , A61B3/10 , A61B3/14 , A61B5/0036 , A61F9/0079 , A61N5/062 , A61B5/0071 , A61B5/4848 , A61F2009/00872 , A61N2005/0661
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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公开(公告)号：US12004811B2
公开(公告)日：2024-06-11
申请号：US18078728
申请日：2022-12-09
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun A. Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
CPC classification number: A61B3/107 , A61B3/10 , A61B3/14 , A61B5/0036 , A61F9/0079 , A61N5/062 , A61B5/0071 , A61B5/4848 , A61F2009/00872 , A61N2005/0661
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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