公开(公告)号：US20210393853A1

公开(公告)日：2021-12-23

申请号：US17290110

申请日：2019-10-29

Applicant: Avery Therapeutics, Inc.

Inventor： Jordan J. Lancaster ,  Jennifer Watson Koevary ,  Steven Goldman

IPC: A61L27/38 ,  A61L27/36 ,  A61L27/58 ,  A01N1/02

Abstract: Systems, methods, and compositions for cryopreservation and reconstitution of engineered tissues. The engineered tissue compositions are functional after a cryopreservation-thaw cycle For example, the tissue compositions retain their structural integrity, maintain cell-cell communication, etc. In certain embodiments, the tissue compositions exhibit synchronous contractions, secrete a hormone, secrete a cytokine, secrete an RNA, secrete a growth factor, secrete an enzyme, and/or secrete a neurotransmitter, etc. in some embodiments, engineered tissue compositions are cultured, cryopreserved, and reconstituted in a closed system.

公开(公告)号：US20180361025A1

公开(公告)日：2018-12-20

申请号：US16010120

申请日：2018-06-15

Applicant: Avery Therapeutics, Inc.

Inventor： Jordan J. Lancaster ,  Steven Goldman ,  Jennifer Watson Koevary

IPC: A61L27/36 ,  A61L27/58 ,  A61L27/22 ,  A61L27/38

Abstract: Engineered tissue compositions for supporting cell growth, maintenance, and/or differentiation featuring a scaffold, extracellular matrix (ECM) material, and optionally a population of ECM-generating cells such as fibroblasts. The tissue compositions may be used for supporting seeded cells of a particular cell type of interest such as cells related to skeletal muscle, smooth muscle, cardiac tissue, gastrointestinal tissue, etc. The tissue compositions with seeded cells may develop into functional tissues, which may have the potential to provide a tissue graft for therapeutic purposes or a valuable model for in vitro assays.

公开(公告)号：US11890395B2

公开(公告)日：2024-02-06

申请号：US16010120

申请日：2018-06-15

Applicant: Avery Therapeutics, Inc.

Inventor： Jordan J. Lancaster ,  Steven Goldman ,  Jennifer Watson Koevary

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/58 ,  A61L27/56 ,  A61L27/22 ,  A61L27/34

CPC classification number: A61L27/3633 ,  A61L27/22 ,  A61L27/34 ,  A61L27/3691 ,  A61L27/383 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3821 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/56 ,  A61L27/58 ,  A61L27/367 ,  A61L27/3873 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2420/00 ,  A61L2430/20 ,  A61L2430/40

Abstract: Engineered tissue compositions for supporting cell growth, maintenance, and/or differentiation featuring a scaffold, extracellular matrix (ECM) material, and optionally a population of ECM-generating cells such as fibroblasts. The tissue compositions may be used for supporting seeded cells of a particular cell type of interest such as cells related to skeletal muscle, smooth muscle, cardiac tissue, gastrointestinal tissue, etc. The tissue compositions with seeded cells may develop into functional tissues, which may have the potential to provide a tissue graft for therapeutic purposes or a valuable model for in vitro assays.

公开(公告)号：US20240131225A1

公开(公告)日：2024-04-25

申请号：US18539055

申请日：2023-12-13

Applicant: Avery Therapeutics, Inc.

Inventor： Jordan J. Lancaster ,  Steven Goldman ,  Jennifer Watson Koevary

IPC: A61L27/38 ,  A61L27/36 ,  A61L27/56

CPC classification number: A61L27/3873 ,  A61L27/3633 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/20

Abstract: Engineered tissue compositions for supporting cell growth, maintenance, and/or differentiation featuring a scaffold, including a dual fiber scaffold, extracellular matrix (ECM) material, and optionally a population of ECM-generating cells such as fibroblasts. The tissue compositions may be used for supporting seeded cells of a particular cell type of interest such as cells related to skeletal muscle, smooth muscle, cardiac tissue, gastrointestinal tissue, etc. The tissue compositions with seeded cells may develop into functional tissues, which may have the potential to provide a tissue graft for therapeutic purposes or a valuable model for in vitro assays.

公开(公告)号：US20210386827A1

公开(公告)日：2021-12-16

申请号：US17285853

申请日：2019-10-15

Applicant: Avery Therapeutics, Inc.

Inventor： Jennifer Watson Koevary ,  Jordan J. Lancaster ,  Steven Goldman

IPC: A61K38/20 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/30

Abstract: Cell-free compositions for promoting restoration of tissue function or enhancement of tissue function and methods of stimulating or promoting restoration or enhancement of tissue function using the cell-free compositions. The compositions herein help stimulate endogenous pathways via a subject's own cells effectively for improving tissue function, enhancing tissue function, enhancing cell proliferation, etc. The compositions comprise one or a plurality of therapeutic components such as growth factors, extracellular matrix, DNA, RNA, hormones, drugs, cell surface receptors, enzymes, cytokines, angiogenesis modulating factors, etc., e.g., any material that can effectively activation endogenous pathways in the subject's own cell to a desired effect. The cell-free composition comprises a carrier or is attached to or integrated into and/or within a carrier. The carrier may help provide for containment of the therapeutic components and/or provide for time-release of the therapeutic components of the cell-free composition.