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公开(公告)号：US20090011075A1
公开(公告)日：2009-01-08
申请号：US11912925
申请日：2006-04-27
申请人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
IPC分类号： A23L1/30
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译： 本文公开了包含甘油磷脂如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI）以及鞘脂如鞘氨醇（SM）的极性脂质混合物。 最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。 本文还描述了制备所述混合物的方法及其用途。
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公开(公告)号：US09814252B2
公开(公告)日：2017-11-14
申请号：US13205071
申请日：2011-08-08
申请人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
IPC分类号： A23J7/00 , A23L33/115
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
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公开(公告)号：US20110294757A1
公开(公告)日：2011-12-01
申请号：US13205071
申请日：2011-08-08
申请人： Avidor SHULMAN , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人： Avidor SHULMAN , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译： 本文公开了包含甘油磷脂如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI）以及鞘脂如鞘氨醇（SM）的极性脂质混合物。 最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。 本文还描述了制备所述混合物的方法及其用途。
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公开(公告)号：US08324187B2
公开(公告)日：2012-12-04
申请号：US10572782
申请日：2004-09-26
申请人： Dorit Plat , Avidor Shulman , Gai Ben Dror , Neta Scheinman , Yoni Twito , Rassan Zuabi
发明人： Dorit Plat , Avidor Shulman , Gai Ben Dror , Neta Scheinman , Yoni Twito , Rassan Zuabi
CPC分类号： C12P13/06 , A23J7/00 , A23L33/10 , A23V2002/00 , A61K31/685 , A61K45/06 , C07F9/103 , C07F9/106 , C12P9/00 , A23V2250/1852 , A23V2200/322
摘要： Disclosed are stable PS preparations, in powder, liquid and dispersion forms, as well as methods of producing thereof. Most importantly, the stable PS preparations are particularly devoid of residual phospholipase D activity, and the methods of eliminating such activity are also described herein. Lastly, uses of these PS preparations in nutraceuticals or as active agents of pharmaceutical compositions are also provided herein.
摘要翻译： 公开了以粉末，液体和分散体形式的稳定的PS制剂，以及其制备方法。 最重要的是，稳定的PS制剂特别缺乏残留的磷脂酶D活性，并且本文还描述了消除这种活性的方法。 最后，本文还提供这些PS制剂在营养药物中或作为药物组合物的活性剂的用途。
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公开(公告)号：US20070160659A1
公开(公告)日：2007-07-12
申请号：US10572782
申请日：2006-11-08
申请人： Dorit Platt , Avidor Shulman , Gai Dror , Neta Scheinman , Yoni Twito , Rassan Zuabi
发明人： Dorit Platt , Avidor Shulman , Gai Dror , Neta Scheinman , Yoni Twito , Rassan Zuabi
IPC分类号： A61K31/685 , A61K9/48 , A61K9/127
CPC分类号： C12P13/06 , A23J7/00 , A23L33/10 , A23V2002/00 , A61K31/685 , A61K45/06 , C07F9/103 , C07F9/106 , C12P9/00 , A23V2250/1852 , A23V2200/322
摘要： Disclosed are stable PS preparations, in powder, liquid and dispersion forms, as well as methods of producing thereof. Most importantly, the stable PS preparations are particularly devoid of residual phospholipase D activity, and the methods of eliminating such activity are also described herein. Lastly, uses of these PS preparations in nutraceuticals or as active agents of pharmaceutical compositions are also provided herein.
摘要翻译： 公开了以粉末，液体和分散体形式的稳定的PS制剂，以及其制备方法。 最重要的是，稳定的PS制剂特别缺乏残留的磷脂酶D活性，并且本文还描述了消除这种活性的方法。 最后，本文还提供了这些PS制剂在营养药物中或作为药物组合物的活性剂的用途。
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