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公开(公告)号：US08324187B2
公开(公告)日：2012-12-04
申请号：US10572782
申请日：2004-09-26
申请人： Dorit Plat , Avidor Shulman , Gai Ben Dror , Neta Scheinman , Yoni Twito , Rassan Zuabi
发明人： Dorit Plat , Avidor Shulman , Gai Ben Dror , Neta Scheinman , Yoni Twito , Rassan Zuabi
CPC分类号： C12P13/06 , A23J7/00 , A23L33/10 , A23V2002/00 , A61K31/685 , A61K45/06 , C07F9/103 , C07F9/106 , C12P9/00 , A23V2250/1852 , A23V2200/322
摘要： Disclosed are stable PS preparations, in powder, liquid and dispersion forms, as well as methods of producing thereof. Most importantly, the stable PS preparations are particularly devoid of residual phospholipase D activity, and the methods of eliminating such activity are also described herein. Lastly, uses of these PS preparations in nutraceuticals or as active agents of pharmaceutical compositions are also provided herein.
摘要翻译： 公开了以粉末，液体和分散体形式的稳定的PS制剂，以及其制备方法。 最重要的是，稳定的PS制剂特别缺乏残留的磷脂酶D活性，并且本文还描述了消除这种活性的方法。 最后，本文还提供这些PS制剂在营养药物中或作为药物组合物的活性剂的用途。
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公开(公告)号：US20090011075A1
公开(公告)日：2009-01-08
申请号：US11912925
申请日：2006-04-27
申请人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
IPC分类号： A23L1/30
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译： 本文公开了包含甘油磷脂如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI）以及鞘脂如鞘氨醇（SM）的极性脂质混合物。 最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。 本文还描述了制备所述混合物的方法及其用途。
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公开(公告)号：US09814252B2
公开(公告)日：2017-11-14
申请号：US13205071
申请日：2011-08-08
申请人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
IPC分类号： A23J7/00 , A23L33/115
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
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公开(公告)号：US07968112B2
公开(公告)日：2011-06-28
申请号：US11872440
申请日：2007-10-15
申请人： Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
发明人： Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
CPC分类号： A61K31/685 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23V2002/00 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidyicholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.
摘要翻译： 包括甘油磷脂或盐的缀合物及其衍生物，特别是磷脂酰丝氨酸（PS），磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰肌醇（PI），磷脂酰甘油（PG）和磷脂酸（PA） - 不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基如ω-3和/或ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，并用于维持脑相关系统和过程的正常功能。
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公开(公告)号：US20110294757A1
公开(公告)日：2011-12-01
申请号：US13205071
申请日：2011-08-08
申请人： Avidor SHULMAN , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人： Avidor SHULMAN , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译： 本文公开了包含甘油磷脂如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI）以及鞘脂如鞘氨醇（SM）的极性脂质混合物。 最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。 本文还描述了制备所述混合物的方法及其用途。
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6.发明授权Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions 有权含有ω-3和ω-6脂肪酸的甘油磷脂及其在治疗和改善认知功能中的应用公开(公告)号：US08052992B2
公开(公告)日：2011-11-08
申请号：US11414150
申请日：2006-04-28
申请人： Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
发明人： Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
CPC分类号： A21D2/32 , A23D7/011 , A23D7/013 , A23D9/013 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/685 , C07F9/106 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： Disclosed herein is a lipid preparation, said preparation comprising a phosphatidylserine moiety, and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. Said lipid preparations are particularly useful in the treatment of mental and cognitive disorders, e.g. ADHD (attention deficit hyperactivity disorder) and Alzheimer's disease.The disclosed preparations present improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders, as well as for maintenance of normal functions of brain-related systems and processes.
摘要翻译： 本文公开了一种脂质制剂，所述制剂包含磷脂酰丝氨酸部分和多不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基，例如ω-3和/或 ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 所述脂质制剂特别可用于治疗精神和认知障碍，例如， ADHD（注意缺陷多动障碍）和阿尔茨海默病。 所公开的制剂提供了改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，以及维持脑相关系统和过程的正常功能。
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公开(公告)号：US20160015820A1
公开(公告)日：2016-01-21
申请号：US14871260
申请日：2015-09-30
申请人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
发明人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
CPC分类号： A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.
摘要翻译： 本文描述的本发明提供包含非哺乳动物衍生的丝氨酸甘油磷脂缀合物的混合物的制剂，其具有LA，亚麻酸（α-亚麻酸，γ-亚麻酸）DHA和EPA的特定含量和特异性缀合图案，其依赖于使用不同的 脂质来源，以及这些制剂的用途。
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公开(公告)号：US09168310B2
公开(公告)日：2015-10-27
申请号：US14063401
申请日：2013-10-25
申请人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
发明人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
CPC分类号： A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.
摘要翻译： 本文描述的本发明提供包含非哺乳动物衍生的丝氨酸甘油磷脂缀合物的混合物的制剂，其具有LA，亚麻酸（α-亚麻酸，γ-亚麻酸）DHA和EPA的特定含量和特异性缀合图案，其依赖于使用不同的 脂质来源，以及这些制剂的用途。
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公开(公告)号：US08470345B2
公开(公告)日：2013-06-25
申请号：US12590893
申请日：2009-11-16
申请人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
发明人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
IPC分类号： A61K31/685 , A61P25/00
CPC分类号： A61K31/685 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23V2002/00 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.
摘要翻译： 一种包含甘油磷脂或盐的缀合物及其衍生物，特别是磷脂酰丝氨酸（PS），磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰肌醇（PI），磷脂酰甘油（PG）和磷脂酸（PA） - 不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基如ω-3和/或ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，并用于维持脑相关系统和过程的正常功能。
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公开(公告)号：US08568773B2
公开(公告)日：2013-10-29
申请号：US12934338
申请日：2009-06-24
申请人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
发明人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
CPC分类号： A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.
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